First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
SB INVESTMENT ADVISERS (UK) LTDCIK 0001731509 | 27,904,963 | $277.65M | – | no_change |
Commodore Capital LPCIK 0001831942 | 17,000,000 | $169.15M | – | no_change |
Casdin Capital, LLCCIK 0001534261 | 14,418,574 | $143.46M | +1,415,000 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 12,975,299 | $129.10M | -253,203 | ↓ DEC |
PERCEPTIVE ADVISORS LLCCIK 0001224962 | 9,751,141 | $97.02M | +7,847,896 | ↑ INC |
Bellevue Group AGCIK 0001674546 | 7,795,242 | $77.56M | -550,122 | ↓ DEC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 7,387,465 | $73.51M | +7,387,465 | NEW |
STATE STREET CORPCIK 0000093751 | 6,233,545 | $62.02M | -192,566 | ↓ DEC |
Nextech Invest, Ltd.CIK 0001595430 | 5,526,506 | $54.99M | +825,000 | ↑ INC |
TCG Crossover Management, LLCCIK 0001839948 | 4,273,356 | $42.52M | +1,053,170 | ↑ INC |
FMR LLCCIK 0000315066 | 3,695,431 | $36.77M | +3,533,209 | ↑ INC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 3,510,636 | $34.94M | +101,273 | ↑ INC |
BALYASNY ASSET MANAGEMENT L.P.CIK 0001218710 | 3,039,179 | $30.24M | +939,267 | ↑ INC |
Spruce Street Capital LPCIK 0002050194 | 2,984,125 | $29.69M | – | no_change |
DIMENSIONAL FUND ADVISORS LPCIK 0000354204 | 2,940,536 | $29.25M | +460,186 | ↑ INC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 2,541,861 | $25.29M | +682,227 | ↑ INC |
MPM BioImpact LLCCIK 0001687078 | 2,359,586 | $23.48M | +127,135 | ↑ INC |
BANK OF AMERICA CORP /DE/CIK 0000070858 | 1,937,695 | $19.28M | +896,746 | ↑ INC |
EcoR1 Capital, LLCCIK 0001587114 | 1,904,762 | $18.95M | +1,263,336 | ↑ INC |
VANGUARD PORTFOLIO MANAGEMENT LLCCIK 0002100121 | 1,863,565 | $18.54M | +1,863,565 | NEW |
NORTHERN TRUST CORPCIK 0000073124 | 1,675,387 | $16.67M | +536,699 | ↑ INC |
Alphabet Inc.CIK 0001652044 | 1,564,173 | $15.56M | -4,580 | ↓ DEC |
MORGAN STANLEYCIK 0000895421 | 1,432,003 | $14.25M | -586,461 | ↓ DEC |
TWO SIGMA INVESTMENTS, LPCIK 0001179392 | 1,369,149 | $13.62M | -191,116 | ↓ DEC |
AQR CAPITAL MANAGEMENT LLCCIK 0001167557 | 1,290,032 | $12.84M | +126,908 | ↑ INC |
| Filer | Δ Shares | Value |
|---|---|---|
PERCEPTIVE ADVISORS LLC↑ INC | +7,847,896 | $97.02M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +7,387,465 | $73.51M |
FMR LLC↑ INC | +3,533,209 | $36.77M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +1,863,565 | $18.54M |
Casdin Capital, LLC↑ INC | +1,415,000 | $143.46M |
EcoR1 Capital, LLC↑ INC | +1,263,336 | $18.95M |
TCG Crossover Management, LLC↑ INC | +1,053,170 | $42.52M |
BALYASNY ASSET MANAGEMENT L.P.↑ INC | +939,267 | $30.24M |
VANGUARD FIDUCIARY TRUST CONEW | +900,546 | $8.96M |
BANK OF AMERICA CORP /DE/↑ INC | +896,746 | $19.28M |
| Filer | Δ Shares | Value |
|---|---|---|
Exome Asset Management LLC↓ DEC | -805,185 | $2.77M |
MORGAN STANLEY↓ DEC | -586,461 | $14.25M |
Bellevue Group AG↓ DEC | -550,122 | $77.56M |
MILLENNIUM MANAGEMENT LLC↓ DEC | -549,176 | $3.46M |
Trexquant Investment LP↓ DEC | -377,797 | $937.77K |
BARCLAYS PLC↓ DEC | -368,876 | $450.41K |
BlackRock, Inc.↓ DEC | -253,203 | $129.10M |
Eversept Partners, LP↓ DEC | -218,432 | $2.69M |
Invesco Ltd.↓ DEC | -195,607 | $6.67M |
STATE STREET CORP↓ DEC | -192,566 | $62.02M |