| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jul 1, 2026 | Santos da Silva Jorge | Chief Executive Officer | S | 47,775 | $20.0300 | $956.93K |
| Jun 22, 2026 | Bodenstedt Matthias | Chief Financial Officer | S | 39,120 | $22.0400 | $862.20K |
| Jun 18, 2026 | Bodenstedt Matthias | Chief Financial Officer | S | 2,794 | $19.6000 | $54.76K |
| Jun 17, 2026 | Loy Spike | Director | A | 22,195 | $0.0000 | $0.00 |
| Jun 17, 2026 | Xavier Ramnik | Director | A | 22,195 | $0.0000 | $0.00 |
| Jun 17, 2026 | Moukheibir Catherine | Director | A | 22,195 | $0.0000 | $0.00 |
| Jun 17, 2026 | Phillips Andrew John | Director | A | 22,195 | $0.0000 | $0.00 |
| Jun 17, 2026 | Bodenstedt Matthias | Chief Financial Officer | S | 15,082 | $19.6800 | $296.81K |
| Jun 17, 2026 | BVF PARTNERS L P/IL | Director, 10% Owner | A | 22,195 | $0.0000 | $0.00 |
| Jun 17, 2026 | Reich Kristian | Chief Scientific Officer | S | 50,000 | $19.4300 | $971.50K |
| Jun 16, 2026 | Reich Kristian | Chief Scientific Officer | S | 50,000 | $18.7000 | $935.00K |
| Jun 15, 2026 | Reich Kristian | Chief Scientific Officer | S | 50,000 | $18.8900 | $944.50K |
| May 11, 2026 | Bodenstedt Matthias | Chief Financial Officer | S | 13,653 | $20.0200 | $273.33K |
| Apr 14, 2026 | Bodenstedt Matthias | Chief Financial Officer | S | 2,426 | $19.5600 | $47.45K |
| Apr 13, 2026 | Santos da Silva Jorge | Chief Executive Officer | S | 51,873 | $18.2300 | $945.64K |
| Apr 10, 2026 | Bodenstedt Matthias | Chief Financial Officer | S | 1,925 | $19.5100 | $37.56K |
| Apr 10, 2026 | Santos da Silva Jorge | Chief Executive Officer | S | 98,127 | $18.4100 | $1.81M |
| Apr 9, 2026 | Bodenstedt Matthias | Chief Financial Officer | S | 85,870 | $18.9400 | $1.63M |
| Mar 31, 2026 | BVF PARTNERS L P/IL | Director, 10% Owner | S | 248,530 | $16.7900 | $4.17M |
| Mar 31, 2026 | BVF PARTNERS L P/IL | Director, 10% Owner | S | 1,569,116 | $16.7900 | $26.35M |
| Mar 31, 2026 | BVF PARTNERS L P/IL | Director, 10% Owner | S | 1,932,354 | $16.7900 | $32.44M |
| Jan 7, 2026 | Reich Kristian | Chief Scientific Officer | A | 520,342 | $0.0000 | $0.00 |
| Jan 7, 2026 | Santos da Silva Jorge | Chief Executive Officer | A | 520,342 | $0.0000 | $0.00 |
| Jan 7, 2026 | Bodenstedt Matthias | Chief Financial Officer | A | 354,296 | $0.0000 | $0.00 |
| Dec 19, 2025 | Santos da Silva Jorge | Chief Executive Officer | C | 5,836 | – | – |
| Dec 19, 2025 | Santos da Silva Jorge | Chief Executive Officer | D | 196,316 | – | – |
| Dec 19, 2025 | Santos da Silva Jorge | Chief Executive Officer | C | 196,316 | – | – |
| Dec 19, 2025 | Bodenstedt Matthias | Chief Financial Officer | C | 8,754 | – | – |
| Dec 19, 2025 | Bodenstedt Matthias | Chief Financial Officer | D | 294,473 | – | – |
| Dec 19, 2025 | Bodenstedt Matthias | Chief Financial Officer | C | 294,473 | – | – |
| Dec 19, 2025 | Reich Kristian | Chief Scientific Officer | C | 1,052 | – | – |
| Dec 19, 2025 | Reich Kristian | Chief Scientific Officer | D | 35,389 | – | – |
| Dec 19, 2025 | Reich Kristian | Chief Scientific Officer | C | 35,389 | – | – |
| Dec 9, 2025 | Reich Kristian | Chief Scientific Officer | S | 72,908 | $14.4300 | $1.05M |
| Dec 9, 2025 | Santos da Silva Jorge | Chief Executive Officer | S | 70,000 | $14.4900 | $1.01M |
| Dec 8, 2025 | Reich Kristian | Chief Scientific Officer | S | 130,000 | $15.0800 | $1.96M |
| Dec 8, 2025 | Santos da Silva Jorge | Chief Executive Officer | S | 130,000 | $15.0800 | $1.96M |
| Oct 8, 2025 | Bodenstedt Matthias | Chief Financial Officer | P | 10,870 | $9.0900 | $98.81K |
| Sep 30, 2025 | Chen Bihua | Other | S | 5,827 | $6.9600 | $40.55K |
| Sep 29, 2025 | Chen Bihua | Other | S | 2,800,000 | $6.6100 | $18.51M |
| Sep 29, 2025 | Chen Bihua | Other | S | 3,390,943 | $7.5800 | $25.70M |
| Sep 29, 2025 | Chen Bihua | Other | S | 232,460 | $8.4000 | $1.95M |
| Sep 29, 2025 | Chen Bihua | Other | S | 70,748 | $9.3800 | $663.62K |
| Sep 2, 2025 | Reich Kristian | Chief Scientific Officer | D | 48,978 | – | – |
| Sep 2, 2025 | Reich Kristian | Chief Scientific Officer | C | 48,978 | – | – |
| Jul 3, 2025 | Moukheibir Catherine | Director | M | 23,500 | $0.0000 | $0.00 |
| Jul 3, 2025 | Moukheibir Catherine | Director | S | 23,500 | $48.7900 | $1.15M |
| Jul 3, 2025 | Moukheibir Catherine | Director | M | 23,500 | $0.0000 | $0.00 |
| Jun 5, 2025 | Phillips Andrew John | Director | A | 6,682 | $0.0000 | $0.00 |
| Jun 5, 2025 | Xavier Ramnik | Director | A | 6,682 | $0.0000 | $0.00 |