第一手 SEC EDGAR 13F-HR 機構持倉:依市值排序的前 25 大持有人，以及本季增持 / 減持最多的機構。季度 2026-03-31。
| 申報機構 | 持股數 | 市值 | Δ 持股 | 變動 |
|---|---|---|---|---|
FARALLON CAPITAL MANAGEMENT, L.L.C.CIK 0000909661 | 13,604,796 | $1.32B | -978,000 | ↓ DEC |
BlackRock, Inc.CIK 0002012383 | 11,212,706 | $1.09B | +2,286,050 | ↑ INC |
BAKER BROS. ADVISORS LPCIK 0001263508 | 9,555,357 | $929.26M | +100,000 | ↑ INC |
FMR LLCCIK 0000315066 | 8,464,314 | $823.15M | -123,667 | ↓ DEC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 8,362,284 | $813.23M | +8,362,284 | NEW |
Nextech Invest, Ltd.CIK 0001595430 | 7,601,087 | $739.21M | – | no_change |
VANGUARD PORTFOLIO MANAGEMENT LLCCIK 0002100121 | 7,502,623 | $729.63M | +7,502,623 | NEW |
Paradigm Biocapital Advisors LPCIK 0001855655 | 6,655,703 | $647.27M | +11,300 | ↑ INC |
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219 | 6,027,819 | $586.21M | -959,820 | ↓ DEC |
STATE STREET CORPCIK 0000093751 | 4,402,662 | $428.16M | +293,372 | ↑ INC |
UBS Group AGCIK 0001610520 | 4,394,291 | $427.34M | +1,306,354 | ↑ INC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 3,338,142 | $323.93M | +176,179 | ↑ INC |
Alphabet Inc.CIK 0001652044 | 3,292,525 | $320.20M | -52,577 | ↓ DEC |
BVF INC/ILCIK 0001056807 | 2,856,782 | $277.82M | -500,000 | ↓ DEC |
Casdin Capital, LLCCIK 0001534261 | 2,577,333 | $250.65M | – | no_change |
Woodline Partners LPCIK 0001784547 | 2,506,570 | $243.76M | +5,675 | ↑ INC |
Holocene Advisors, LPCIK 0001700574 | 2,468,644 | $240.08M | +560,696 | ↑ INC |
Vestal Point Capital, LPCIK 0001974915 | 2,375,000 | $230.97M | +2,080,000 | ↑ INC |
Avoro Capital Advisors LLCCIK 0001633313 | 2,344,444 | $228.00M | +174,444 | ↑ INC |
DEERFIELD MANAGEMENT COMPANY, L.P.CIK 0001009258 | 2,297,000 | $223.38M | -597,613 | ↓ DEC |
SUSQUEHANNA INTERNATIONAL GROUP, LLPCIK 0001446194 | 2,229,085 | $216.78M | +998,664 | ↑ INC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 2,185,500 | $212.54M | -347,774 | ↓ DEC |
Darwin Global Management, Ltd.CIK 0001839209 | 2,211,018 | $204.98M | +2,211,018 | NEW |
Alyeska Investment Group, L.P.CIK 0001453072 | 1,885,821 | $183.40M | +1,646,724 | ↑ INC |
Caligan Partners LPCIK 0001727492 | 1,881,708 | $183.00M | +597,808 | ↑ INC |
| 申報機構 | Δ 持股 | 市值 |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +8,362,284 | $813.23M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +7,502,623 | $729.63M |
BlackRock, Inc.↑ INC | +2,286,050 | $1.09B |
Darwin Global Management, Ltd.NEW | +2,211,018 | $204.98M |
Vestal Point Capital, LP↑ INC | +2,080,000 | $230.97M |
Abu Dhabi Investment Council Co P.J.S.CNEW | +1,739,859 | $19.08M |
NATIONAL BANK OF CANADA /FI/↑ INC | +1,718,217 | $170.09M |
Alyeska Investment Group, L.P.↑ INC | +1,646,724 | $183.40M |
UBS Group AG↑ INC | +1,306,354 | $427.34M |
TWO SIGMA INVESTMENTS, LP↑ INC | +1,137,072 | $151.59M |
| 申報機構 | Δ 持股 | 市值 |
|---|---|---|
Bellevue Group AG↓ DEC | -3,461,263 | $150.20M |
GENERAL ATLANTIC, L.P.↓ DEC | -2,105,137 | $68.83M |
Lunate Capital Ltd↓ DEC | -1,647,150 | $53.40M |
WESTFIELD CAPITAL MANAGEMENT CO LP↓ DEC | -1,288,435 | $151.38M |
Jefferies Financial Group Inc.↓ DEC | -1,138,705 | $242.15K |
FARALLON CAPITAL MANAGEMENT, L.L.C.↓ DEC | -978,000 | $1.32B |
WELLINGTON MANAGEMENT GROUP LLP↓ DEC | -959,820 | $586.21M |
JANE STREET GROUP, LLC↓ DEC | -849,813 | $35.99M |
M&T BANK CORP↓ DEC | -653,721 | $798.23K |
T. Rowe Price Investment Management, Inc.↓ DEC | -636,210 | $64.58K |