第一手 SEC EDGAR 13F-HR 機構持倉:依市值排序的前 25 大持有人，以及本季增持 / 減持最多的機構。季度 2026-03-31。
| 申報機構 | 持股數 | 市值 | Δ 持股 | 變動 |
|---|---|---|---|---|
DEERFIELD MANAGEMENT COMPANY, L.P.CIK 0001009258 | 17,248,450 | $1.77B | – | no_change |
FMR LLCCIK 0000315066 | 9,274,959 | $950.22M | -1,577,925 | ↓ DEC |
Paradigm Biocapital Advisors LPCIK 0001855655 | 5,324,433 | $545.49M | +55,000 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 4,824,785 | $494.30M | +19,524 | ↑ INC |
JPMORGAN CHASE & COCIK 0000019617 | 3,088,349 | $298.71M | +883,098 | ↑ INC |
VANGUARD PORTFOLIO MANAGEMENT LLCCIK 0002100121 | 2,500,907 | $256.22M | +2,500,907 | NEW |
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219 | 2,470,491 | $253.10M | +8,668 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 2,428,488 | $248.80M | +2,428,488 | NEW |
STATE STREET CORPCIK 0000093751 | 2,035,831 | $208.57M | +171,156 | ↑ INC |
PERCEPTIVE ADVISORS LLCCIK 0001224962 | 1,580,505 | $161.92M | -84,600 | ↓ DEC |
Deep Track Capital, LPCIK 0001856083 | 1,376,324 | $141.00M | +1,101,812 | ↑ INC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 1,298,107 | $133.02M | +59,873 | ↑ INC |
Bellevue Group AGCIK 0001674546 | 1,053,268 | $107.91M | +15,800 | ↑ INC |
Commodore Capital LPCIK 0001831942 | 833,600 | $85.40M | +283,600 | ↑ INC |
ALLIANCEBERNSTEIN L.P.CIK 0001109448 | 784,023 | $78.86M | -1,422 | ↓ DEC |
BRAIDWELL LPCIK 0001920938 | 700,429 | $71.76M | -120,977 | ↓ DEC |
Woodline Partners LPCIK 0001784547 | 610,459 | $62.54M | – | no_change |
AMERIPRISE FINANCIAL INCCIK 0000820027 | 563,768 | $57.76M | -530 | ↓ DEC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 537,158 | $55.03M | -57,301 | ↓ DEC |
Vestal Point Capital, LPCIK 0001974915 | 481,715 | $49.35M | +435,715 | ↑ INC |
DRIEHAUS CAPITAL MANAGEMENT LLCCIK 0000938206 | 481,180 | $49.30M | -2,324 | ↓ DEC |
Hood River Capital Management LLCCIK 0001578177 | 479,998 | $49.18M | +4,558 | ↑ INC |
CHARLES SCHWAB INVESTMENT MANAGEMENT INCCIK 0000884546 | 450,801 | $46.18M | -2,510 | ↓ DEC |
FRANKLIN RESOURCES INCCIK 0000038777 | 434,742 | $44.54M | +23,388 | ↑ INC |
AMERICAN CENTURY COMPANIES INCCIK 0000748054 | 431,067 | $44.16M | +56,835 | ↑ INC |
| 申報機構 | Δ 持股 | 市值 |
|---|---|---|
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +2,500,907 | $256.22M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +2,428,488 | $248.80M |
Deep Track Capital, LP↑ INC | +1,101,812 | $141.00M |
T. Rowe Price Investment Management, Inc.↑ INC | +1,044,863 | $144.83K |
JPMORGAN CHASE & CO↑ INC | +883,098 | $298.71M |
Vestal Point Capital, LP↑ INC | +435,715 | $49.35M |
VANGUARD FIDUCIARY TRUST CONEW | +364,167 | $37.31M |
Jones Hill Capital LPNEW | +300,830 | $30.82M |
Commodore Capital LP↑ INC | +283,600 | $85.40M |
STATE STREET CORP↑ INC | +171,156 | $208.57M |
| 申報機構 | Δ 持股 | 市值 |
|---|---|---|
FMR LLC↓ DEC | -1,577,925 | $950.22M |
BRAIDWELL LP↓ DEC | -120,977 | $71.76M |
ArrowMark Colorado Holdings LLC↓ DEC | -109,179 | $19.14M |
BARCLAYS PLC↓ DEC | -94,484 | $3.16M |
PRICE T ROWE ASSOCIATES INC /MD/↓ DEC | -90,805 | $210.65K |
PERCEPTIVE ADVISORS LLC↓ DEC | -84,600 | $161.92M |
Rhenman & Partners Asset Management AB↓ DEC | -82,150 | $8.32M |
LORD, ABBETT & CO. LLC↓ DEC | -81,337 | $20.48K |
MORGAN STANLEY↓ DEC | -66,599 | $20.57M |
MILLENNIUM MANAGEMENT LLC↓ DEC | -63,809 | $1.85M |