第一手 SEC EDGAR 13F-HR 機構持倉:依市值排序的前 25 大持有人，以及本季增持 / 減持最多的機構。季度 2026-03-31。
| 申報機構 | 持股數 | 市值 | Δ 持股 | 變動 |
|---|---|---|---|---|
Frazier Life Sciences Management, L.P.CIK 0001892134 | 6,652,013 | $198.56M | – | no_change |
ORBIMED ADVISORS LLCCIK 0001055951 | 3,637,887 | $108.59M | -297,316 | ↓ DEC |
NEA Management Company, LLCCIK 0001512848 | 3,614,486 | $107.89M | – | no_change |
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219 | 3,191,824 | $95.28M | -158,137 | ↓ DEC |
BlackRock, Inc.CIK 0002012383 | 2,941,406 | $87.80M | +21,650 | ↑ INC |
FMR LLCCIK 0000315066 | 2,936,684 | $87.66M | +2,920,938 | ↑ INC |
Deep Track Capital, LPCIK 0001856083 | 2,757,569 | $82.31M | -492,221 | ↓ DEC |
NVP Associates, LLCCIK 0001545692 | 2,136,335 | $63.77M | – | no_change |
BRAIDWELL LPCIK 0001920938 | 1,492,467 | $44.55M | +473,867 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 1,477,592 | $44.11M | +1,477,592 | NEW |
Aaron Wealth Advisors LLCCIK 0001812198 | 1,168,176 | $34.87M | +1,098,176 | ↑ INC |
Cormorant Asset Management, LPCIK 0001583977 | 1,120,000 | $33.43M | – | no_change |
DRIEHAUS CAPITAL MANAGEMENT LLCCIK 0000938206 | 1,018,212 | $30.39M | -389,947 | ↓ DEC |
CITADEL ADVISORS LLCCIK 0001423053 | 968,033 | $28.90M | +132,676 | ↑ INC |
Woodline Partners LPCIK 0001784547 | 900,063 | $26.87M | -100,000 | ↓ DEC |
EVENTIDE ASSET MANAGEMENT, LLCCIK 0001442891 | 890,000 | $26.57M | – | no_change |
Caligan Partners LPCIK 0001727492 | 848,590 | $25.33M | +848,590 | NEW |
Parkman Healthcare Partners LLCCIK 0001777015 | 800,037 | $23.88M | -85,602 | ↓ DEC |
STATE STREET CORPCIK 0000093751 | 787,208 | $23.50M | +114,468 | ↑ INC |
EcoR1 Capital, LLCCIK 0001587114 | 777,000 | $23.19M | -1,346,604 | ↓ DEC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 670,385 | $20.02M | +20,994 | ↑ INC |
TCG Crossover Management, LLCCIK 0001839948 | 650,000 | $19.40M | – | no_change |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 564,415 | $16.85M | +102,366 | ↑ INC |
STEMPOINT CAPITAL LPCIK 0001952142 | 499,469 | $14.91M | +420,916 | ↑ INC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 457,945 | $13.67M | +126,007 | ↑ INC |
| 申報機構 | Δ 持股 | 市值 |
|---|---|---|
FMR LLC↑ INC | +2,920,938 | $87.66M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +1,477,592 | $44.11M |
Aaron Wealth Advisors LLC↑ INC | +1,098,176 | $34.87M |
Caligan Partners LPNEW | +848,590 | $25.33M |
BRAIDWELL LP↑ INC | +473,867 | $44.55M |
STEMPOINT CAPITAL LP↑ INC | +420,916 | $14.91M |
Candriam S.C.A.NEW | +294,374 | $8.79M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +293,295 | $8.75M |
PRICE T ROWE ASSOCIATES INC /MD/↑ INC | +188,501 | $30.72K |
VANGUARD FIDUCIARY TRUST CONEW | +170,154 | $5.08M |
| 申報機構 | Δ 持股 | 市值 |
|---|---|---|
EcoR1 Capital, LLC↓ DEC | -1,346,604 | $23.19M |
Deep Track Capital, LP↓ DEC | -492,221 | $82.31M |
DRIEHAUS CAPITAL MANAGEMENT LLC↓ DEC | -389,947 | $30.39M |
ORBIMED ADVISORS LLC↓ DEC | -297,316 | $108.59M |
SUSQUEHANNA INTERNATIONAL GROUP, LLP↓ DEC | -252,041 | $3.06M |
Soleus Capital Management, L.P.↓ DEC | -230,003 | $5.34M |
WELLINGTON MANAGEMENT GROUP LLP↓ DEC | -158,137 | $95.28M |
Affinity Asset Advisors, LLC↓ DEC | -100,000 | $4.48M |
Woodline Partners LP↓ DEC | -100,000 | $26.87M |
Parkman Healthcare Partners LLC↓ DEC | -85,602 | $23.88M |