第一手 SEC EDGAR 13F-HR 機構持倉:依市值排序的前 25 大持有人，以及本季增持 / 減持最多的機構。季度 2026-03-31。
| 申報機構 | 持股數 | 市值 | Δ 持股 | 變動 |
|---|---|---|---|---|
BAKER BROS. ADVISORS LPCIK 0001263508 | 7,915,792 | $903.51M | – | no_change |
Avoro Capital Advisors LLCCIK 0001633313 | 3,575,000 | $388.27M | +463,889 | ↑ INC |
PERCEPTIVE ADVISORS LLCCIK 0001224962 | 3,127,200 | $356.94M | -33,000 | ↓ DEC |
RTW INVESTMENTS, LPCIK 0001493215 | 3,039,621 | $346.94M | +2,489,461 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 2,711,532 | $309.49M | +171,155 | ↑ INC |
NEA Management Company, LLCCIK 0001512848 | 2,285,561 | $260.87M | -1,250,000 | ↓ DEC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 1,782,894 | $203.50M | +1,782,894 | NEW |
DEERFIELD MANAGEMENT COMPANY, L.P.CIK 0001009258 | 1,714,000 | $195.64M | – | no_change |
STATE STREET CORPCIK 0000093751 | 1,518,705 | $173.34M | -118,982 | ↓ DEC |
MORGAN STANLEYCIK 0000895421 | 1,345,715 | $153.60M | -53,255 | ↓ DEC |
Soleus Capital Management, L.P.CIK 0001802630 | 1,284,378 | $146.60M | -523,880 | ↓ DEC |
TANG CAPITAL MANAGEMENT LLCCIK 0001232621 | 1,050,000 | $119.85M | – | no_change |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 891,070 | $101.73M | +60,386 | ↑ INC |
TORONTO DOMINION BANKCIK 0000947263 | 882,758 | $100.76M | +882,758 | NEW |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 764,975 | $87.31M | +112,148 | ↑ INC |
BANK OF AMERICA CORP /DE/CIK 0000070858 | 714,329 | $81.53M | -262,789 | ↓ DEC |
SUSQUEHANNA INTERNATIONAL GROUP, LLPCIK 0001446194 | 694,697 | $79.29M | +193,002 | ↑ INC |
Sofinnova Investments, Inc.CIK 0001631134 | 666,175 | $76.04M | +366,758 | ↑ INC |
BAKER BROS. ADVISORS LPCIK 0001263508 | 30,750,000 | $74.87M | – | no_change |
Caption Management, LLCCIK 0001706766 | 600,000 | $68.48M | +83,200 | ↑ INC |
APIS CAPITAL ADVISORS, LLCCIK 0001386892 | 515,000 | $58.78M | -87,000 | ↓ DEC |
Nearwater Capital Markets, LtdCIK 0001915842 | 473,100 | $54.00M | -47,100 | ↓ DEC |
Artisan Partners Limited PartnershipCIK 0001466153 | 457,070 | $52.17M | -89,571 | ↓ DEC |
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219 | 428,952 | $48.96M | +57,813 | ↑ INC |
ALLIANCEBERNSTEIN L.P.CIK 0001109448 | 464,328 | $46.31M | -8,610 | ↓ DEC |
| 申報機構 | Δ 持股 | 市值 |
|---|---|---|
RTW INVESTMENTS, LP↑ INC | +2,489,461 | $346.94M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +1,782,894 | $203.50M |
TORONTO DOMINION BANKNEW | +882,758 | $100.76M |
LORD, ABBETT & CO. LLC↑ INC | +822,000 | $14.47K |
Avoro Capital Advisors LLC↑ INC | +463,889 | $388.27M |
Sofinnova Investments, Inc.↑ INC | +366,758 | $76.04M |
Point72 Asset Management, L.P.↑ INC | +317,624 | $36.53M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +291,171 | $33.23M |
LORD, ABBETT & CO. LLC↑ INC | +257,736 | $50.13K |
VANGUARD FIDUCIARY TRUST CONEW | +253,366 | $28.92M |
| 申報機構 | Δ 持股 | 市值 |
|---|---|---|
NEA Management Company, LLC↓ DEC | -1,250,000 | $260.87M |
BRAIDWELL LP↓ DEC | -855,108 | $3.33M |
Soleus Capital Management, L.P.↓ DEC | -523,880 | $146.60M |
Holocene Advisors, LP↓ DEC | -325,361 | $42.23M |
Sio Capital Management, LLC↓ DEC | -283,224 | $22.13M |
BANK OF AMERICA CORP /DE/↓ DEC | -262,789 | $81.53M |
Candriam S.C.A.↓ DEC | -245,767 | $26.32M |
FEDERATED HERMES, INC.↓ DEC | -193,860 | $13.59M |
Qube Research & Technologies Ltd↓ DEC | -175,454 | $3.77M |
STATE STREET CORP↓ DEC | -118,982 | $173.34M |