| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jul 1, 2026 | Kiselak Tomas | Director | A | 32,341 | $0.0000 | $0.00 |
| Jul 1, 2026 | Morris Arlene | Director | A | 32,341 | $0.0000 | $0.00 |
| Jul 1, 2026 | Gheuens Sarah | Director | A | 32,341 | $0.0000 | $0.00 |
| Jul 1, 2026 | Moses Jennifer K. | Director | A | 32,341 | $0.0000 | $0.00 |
| Jul 1, 2026 | Ajer Jeffrey Robert | Director | A | 32,341 | $0.0000 | $0.00 |
| Jul 1, 2026 | CAIN CHRISTOPHER W. | Director | A | 32,341 | $0.0000 | $0.00 |
| May 11, 2026 | Fairmount Funds Management LLC | Director, 10% Owner | P | 1,176,470 | $17.0000 | $20.00M |
| Mar 3, 2026 | Mahoney Stephen F. | President and CEO | M | 18,357 | $0.0000 | $0.00 |
| Mar 3, 2026 | Mahoney Stephen F. | President and CEO | F | 7,627 | $29.3200 | $223.62K |
| Mar 3, 2026 | Mahoney Stephen F. | President and CEO | M | 18,357 | – | – |
| Mar 3, 2026 | Beetham Thomas W. | Chief Operating Officer | M | 9,409 | $0.0000 | $0.00 |
| Mar 3, 2026 | Beetham Thomas W. | Chief Operating Officer | F | 3,138 | $29.3200 | $92.01K |
| Mar 3, 2026 | Beetham Thomas W. | Chief Operating Officer | M | 9,409 | – | – |
| Mar 3, 2026 | Harmon Seth | Chief Financial Officer | M | 6,267 | $0.0000 | $0.00 |
| Mar 3, 2026 | Harmon Seth | Chief Financial Officer | F | 2,091 | $29.3200 | $61.31K |
| Mar 3, 2026 | Harmon Seth | Chief Financial Officer | M | 6,267 | – | – |
| Mar 3, 2026 | Tousignant Jennifer | Chief Legal Officer | M | 5,169 | $0.0000 | $0.00 |
| Mar 3, 2026 | Tousignant Jennifer | Chief Legal Officer | F | 1,724 | $29.3200 | $50.55K |
| Mar 3, 2026 | Tousignant Jennifer | Chief Legal Officer | M | 5,169 | – | – |
| Mar 3, 2026 | Mahoney Stephen F. | President and CEO | F | 7,408 | $30.1900 | $223.65K |
| Mar 3, 2026 | Beetham Thomas W. | Chief Operating Officer | F | 3,048 | $30.1900 | $92.02K |
| Mar 3, 2026 | Tousignant Jennifer | Chief Legal Officer | F | 1,675 | $30.1900 | $50.57K |
| Mar 3, 2026 | Harmon Seth | Chief Financial Officer | F | 2,031 | $30.1900 | $61.31K |
| Mar 2, 2026 | Tripuraneni Radhika | Chief Medical Officer | A | 19,150 | $0.0000 | $0.00 |
| Mar 2, 2026 | Tripuraneni Radhika | Chief Medical Officer | A | 95,800 | $0.0000 | $0.00 |
| Mar 2, 2026 | Mahoney Stephen F. | President and CEO | A | 111,900 | $0.0000 | $0.00 |
| Mar 2, 2026 | Mahoney Stephen F. | President and CEO | A | 559,600 | $0.0000 | $0.00 |
| Mar 2, 2026 | Beetham Thomas W. | Chief Operating Officer | A | 35,300 | $0.0000 | $0.00 |
| Mar 2, 2026 | Beetham Thomas W. | Chief Operating Officer | A | 176,550 | $0.0000 | $0.00 |
| Mar 2, 2026 | Harmon Seth | Chief Financial Officer | A | 20,550 | $0.0000 | $0.00 |
| Mar 2, 2026 | Harmon Seth | Chief Financial Officer | A | 102,850 | $0.0000 | $0.00 |
| Mar 2, 2026 | Tousignant Jennifer | Chief Legal Officer | A | 23,850 | $0.0000 | $0.00 |
| Mar 2, 2026 | Tousignant Jennifer | Chief Legal Officer | A | 119,300 | $0.0000 | $0.00 |
| Dec 31, 2025 | Tousignant Jennifer | Chief Legal Officer | S | 2,272 | $31.1600 | $70.80K |
| Oct 23, 2025 | Fairmount Funds Management LLC | Director, 10% Owner | P | 454,545 | $22.0000 | $10.00M |
| Jul 1, 2025 | Moses Jennifer K. | Director | A | 21,000 | $0.0000 | $0.00 |
| Jul 1, 2025 | Gheuens Sarah | Director | A | 21,000 | $0.0000 | $0.00 |
| Jul 1, 2025 | Ajer Jeffrey Robert | Director | A | 21,000 | $0.0000 | $0.00 |
| Jul 1, 2025 | Morris Arlene | Director | A | 21,000 | $0.0000 | $0.00 |
| Jul 1, 2025 | Kiselak Tomas | Director | A | 21,000 | $0.0000 | $0.00 |
| Jul 1, 2025 | CAIN CHRISTOPHER W. | Director | A | 21,000 | $0.0000 | $0.00 |
| Jun 10, 2025 | Fairmount Funds Management LLC | Director, 10% Owner | M | 12,500 | $0.0000 | $0.00 |
| Jun 10, 2025 | Fairmount Funds Management LLC | Director, 10% Owner | M | 12,500 | $12.3100 | $153.88K |
| Jun 9, 2025 | Fairmount Funds Management LLC | Director, 10% Owner | M | 1,600 | $0.0000 | $0.00 |
| Jun 9, 2025 | Fairmount Funds Management LLC | Director, 10% Owner | M | 1,600 | $7.8000 | $12.48K |
| Apr 7, 2025 | Ajer Jeffrey Robert | Director | A | 42,000 | $0.0000 | $0.00 |
| Mar 10, 2025 | CAIN CHRISTOPHER W. | Director | A | 42,000 | $0.0000 | $0.00 |
| Mar 10, 2025 | Tripuraneni Radhika | Chief Medical Officer | A | 310,700 | $0.0000 | $0.00 |
| Mar 3, 2025 | Harmon Seth | Chief Financial Officer | A | 25,068 | $0.0000 | $0.00 |
| Mar 3, 2025 | Harmon Seth | Chief Financial Officer | A | 150,407 | $0.0000 | $0.00 |