| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 16, 2026 | Ambrose Allison | General Counsel | S | 477 | $6.1000 | $2.91K |
| Jun 16, 2026 | Deykin Aaron | Chief Medical Officer | S | 895 | $6.1000 | $5.46K |
| Jun 16, 2026 | Houghton Adam | Chief Business Officer | S | 700 | $6.1000 | $4.27K |
| Jun 16, 2026 | Sutherland Everett Rand | Chief Executive Officer | S | 2,095 | $6.1000 | $12.78K |
| Jun 16, 2026 | GRAY MICHAEL | CFO and COO | S | 853 | $6.1000 | $5.20K |
| Jun 9, 2026 | Chimovits Erez | Director | A | 17,096 | $0.0000 | $0.00 |
| Jun 9, 2026 | Fleming Harold Edward | Director | A | 17,096 | $0.0000 | $0.00 |
| Jun 9, 2026 | Beckman Daniella | Director | A | 17,096 | $0.0000 | $0.00 |
| Jun 9, 2026 | Ratcliffe Liam | Director | A | 17,096 | $0.0000 | $0.00 |
| Jun 9, 2026 | Renaud Ronald C JR | Director | A | 17,096 | $0.0000 | $0.00 |
| Jun 9, 2026 | Ruddy Marcella K. | Director | A | 17,096 | $0.0000 | $0.00 |
| Mar 16, 2026 | Houghton Adam | Chief Business Officer | S | 699 | $9.2900 | $6.49K |
| Mar 16, 2026 | Ambrose Allison | General Counsel | S | 475 | $9.2900 | $4.41K |
| Mar 16, 2026 | Sutherland Everett Rand | Chief Executive Officer | S | 2,093 | $9.2900 | $19.44K |
| Mar 16, 2026 | Deykin Aaron | Chief Medical Officer | S | 894 | $9.2900 | $8.30K |
| Mar 16, 2026 | GRAY MICHAEL | CFO and COO | S | 852 | $9.2900 | $7.92K |
| Jan 2, 2026 | Ambrose Allison | General Counsel | A | 51,000 | $0.0000 | $0.00 |
| Jan 2, 2026 | Ambrose Allison | General Counsel | A | 17,000 | $0.0000 | $0.00 |
| Jan 2, 2026 | Sutherland Everett Rand | Chief Executive Officer | A | 225,000 | $0.0000 | $0.00 |
| Jan 2, 2026 | Sutherland Everett Rand | Chief Executive Officer | A | 75,000 | $0.0000 | $0.00 |
| Jan 2, 2026 | Houghton Adam | Chief Business Officer | A | 75,000 | $0.0000 | $0.00 |
| Jan 2, 2026 | Houghton Adam | Chief Business Officer | A | 25,000 | $0.0000 | $0.00 |
| Jan 2, 2026 | GRAY MICHAEL | CFO and COO | A | 91,500 | $0.0000 | $0.00 |
| Jan 2, 2026 | GRAY MICHAEL | CFO and COO | A | 30,500 | $0.0000 | $0.00 |
| Jan 2, 2026 | Deykin Aaron | Chief Medical Officer | A | 96,000 | $0.0000 | $0.00 |
| Jan 2, 2026 | Deykin Aaron | Chief Medical Officer | A | 32,000 | $0.0000 | $0.00 |
| Jun 10, 2025 | Ratcliffe Liam | Director | A | 17,096 | $0.0000 | $0.00 |
| Jun 10, 2025 | Fleming Harold Edward | Director | A | 17,096 | $0.0000 | $0.00 |
| Jun 10, 2025 | Beckman Daniella | Director | A | 17,096 | $0.0000 | $0.00 |
| Jun 10, 2025 | Ruddy Marcella K. | Director | A | 17,096 | $0.0000 | $0.00 |
| Jun 10, 2025 | Chimovits Erez | Director | A | 17,096 | $0.0000 | $0.00 |
| Jun 10, 2025 | Renaud Ronald C JR | Director | A | 17,096 | $0.0000 | $0.00 |
| Feb 6, 2025 | Ambrose Allison | General Counsel | A | 25,000 | $0.0000 | $0.00 |
| Feb 6, 2025 | Deykin Aaron | Chief Medical Officer | A | 165,000 | $0.0000 | $0.00 |
| Feb 6, 2025 | GRAY MICHAEL | CFO and COO | A | 195,000 | $0.0000 | $0.00 |
| Feb 6, 2025 | Houghton Adam | Chief Business Officer | A | 140,000 | $0.0000 | $0.00 |
| Feb 6, 2025 | Sutherland Everett Rand | Chief Executive Officer | A | 500,000 | $0.0000 | $0.00 |
| Dec 16, 2024 | Ambrose Allison | General Counsel | A | 100,000 | $0.0000 | $0.00 |
| Oct 15, 2024 | ORBIMED ADVISORS LLC | Director, 10% Owner | C | 789,833 | – | – |
| Oct 15, 2024 | ORBIMED ADVISORS LLC | Director, 10% Owner | C | 197,456 | – | – |
| Oct 15, 2024 | ORBIMED ADVISORS LLC | Director, 10% Owner | C | 2,098,000 | – | – |
| Oct 15, 2024 | ORBIMED ADVISORS LLC | Director, 10% Owner | C | 524,500 | – | – |
| Oct 15, 2024 | ORBIMED ADVISORS LLC | Director, 10% Owner | P | 660,000 | $17.0000 | $11.22M |
| Oct 15, 2024 | ORBIMED ADVISORS LLC | Director, 10% Owner | C | 2,887,833 | – | – |
| Oct 15, 2024 | AI Upstream LLC | 10% Owner | C | 1,172,410 | – | – |
| Oct 15, 2024 | AI Upstream LLC | 10% Owner | C | 3,147,000 | – | – |
| Oct 15, 2024 | AI Upstream LLC | 10% Owner | C | 1,172,410 | – | – |
| Oct 15, 2024 | AI Upstream LLC | 10% Owner | C | 3,147,000 | – | – |
| Oct 15, 2024 | ORBIMED ADVISORS LLC | Director, 10% Owner | P | 165,000 | $17.0000 | $2.81M |
| Oct 15, 2024 | Chimovits Erez | Director, 10% Owner | C | 789,833 | – | – |