First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
FMR LLCCIK 0000315066 | 8,101,563 | $72.91M | +583,361 | ↑ INC |
ORBIMED ADVISORS LLCCIK 0001055951 | 5,693,589 | $51.24M | – | no_change |
BlackRock, Inc.CIK 0002012383 | 3,370,689 | $30.34M | +26,185 | ↑ INC |
Decheng Capital LLCCIK 0002010850 | 2,724,868 | $24.52M | -418,210 | ↓ DEC |
Enavate Sciences GP, LLCCIK 0001953107 | 2,459,703 | $22.14M | – | no_change |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 1,873,574 | $16.86M | +1,873,574 | NEW |
Y-Intercept (Hong Kong) LtdCIK 0001772875 | 1,000,631 | $9.01M | +954,072 | ↑ INC |
FEDERATED HERMES, INC.CIK 0001056288 | 979,758 | $8.82M | +979,276 | ↑ INC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 950,617 | $8.56M | +98,709 | ↑ INC |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 937,323 | $8.44M | +420,059 | ↑ INC |
SEB Asset Management ABCIK 0002127509 | 878,473 | $7.91M | +878,473 | NEW |
Bain Capital Life Sciences Investors, LLCCIK 0001703031 | 867,211 | $7.80M | -462,333 | ↓ DEC |
Woodline Partners LPCIK 0001784547 | 831,481 | $7.48M | +71,229 | ↑ INC |
Parkman Healthcare Partners LLCCIK 0001777015 | 786,783 | $7.08M | -47,776 | ↓ DEC |
Samsara BioCapital, LLCCIK 0001744967 | 736,047 | $6.62M | – | no_change |
Pictet Asset Management Holding SACIK 0001993888 | 733,431 | $6.60M | -39,717 | ↓ DEC |
VANGUARD PORTFOLIO MANAGEMENT LLCCIK 0002100121 | 727,711 | $6.55M | +727,711 | NEW |
STATE STREET CORPCIK 0000093751 | 705,350 | $6.35M | -613,876 | ↓ DEC |
HSBC HOLDINGS PLCCIK 0000873630 | 640,326 | $5.76M | +640,326 | NEW |
Qube Research & Technologies LtdCIK 0001729829 | 619,321 | $5.57M | +619,321 | NEW |
MORGAN STANLEYCIK 0000895421 | 552,609 | $4.97M | +430,541 | ↑ INC |
JPMORGAN CHASE & COCIK 0000019617 | 463,001 | $4.07M | +352,721 | ↑ INC |
SPHERA FUNDS MANAGEMENT LTD.CIK 0001496201 | 358,000 | $3.22M | +358,000 | NEW |
Propel Bio Management, LLCCIK 0001969764 | 341,779 | $3.10M | +341,779 | NEW |
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219 | 342,353 | $3.08M | -552,380 | ↓ DEC |
| Filer | Δ Shares | Value |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +1,873,574 | $16.86M |
FEDERATED HERMES, INC.↑ INC | +979,276 | $8.82M |
Y-Intercept (Hong Kong) Ltd↑ INC | +954,072 | $9.01M |
SEB Asset Management ABNEW | +878,473 | $7.91M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +727,711 | $6.55M |
HSBC HOLDINGS PLCNEW | +640,326 | $5.76M |
Qube Research & Technologies LtdNEW | +619,321 | $5.57M |
FMR LLC↑ INC | +583,361 | $72.91M |
MORGAN STANLEY↑ INC | +430,541 | $4.97M |
MILLENNIUM MANAGEMENT LLC↑ INC | +420,059 | $8.44M |
| Filer | Δ Shares | Value |
|---|---|---|
UBS Group AG↓ DEC | -1,574,989 | $2.08M |
STATE STREET CORP↓ DEC | -613,876 | $6.35M |
TCG Crossover Management, LLC↓ DEC | -562,823 | $1.63M |
WELLINGTON MANAGEMENT GROUP LLP↓ DEC | -552,380 | $3.08M |
BARCLAYS PLC↓ DEC | -499,779 | $222.48K |
Bain Capital Life Sciences Investors, LLC↓ DEC | -462,333 | $7.80M |
Decheng Capital LLC↓ DEC | -418,210 | $24.52M |
MARSHALL WACE, LLP↓ DEC | -277,021 | $600.93K |
Invesco Ltd.↓ DEC | -122,676 | $364.59K |
SUSQUEHANNA INTERNATIONAL GROUP, LLP↓ DEC | -53,880 | $557.65K |