| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| May 28, 2026 | Rothenberg Stephen Michael | Director | A | 13,160 | $0.0000 | $0.00 |
| May 28, 2026 | MORE ROBERT J | Director | A | 13,160 | $0.0000 | $0.00 |
| May 28, 2026 | Gulfo Adele M. | Director | A | 13,160 | $0.0000 | $0.00 |
| May 28, 2026 | Simson Jake | Director | A | 13,160 | $0.0000 | $0.00 |
| May 28, 2026 | Moran Susan | Director | A | 13,160 | $0.0000 | $0.00 |
| May 28, 2026 | Verjee Rehan | Director | A | 13,160 | $0.0000 | $0.00 |
| May 28, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | A | 13,160 | $0.0000 | $0.00 |
| May 5, 2026 | Rueb Yuliya | Vice President, Finance (PAO) | A | 28,000 | $0.0000 | $0.00 |
| May 5, 2026 | Rueb Yuliya | Vice President, Finance (PAO) | A | 8,333 | $0.0000 | $0.00 |
| May 5, 2026 | Ashar Bhavesh | Chief Operating Officer | A | 50,295 | $0.0000 | $0.00 |
| May 5, 2026 | Ashar Bhavesh | Chief Operating Officer | A | 15,013 | $0.0000 | $0.00 |
| May 5, 2026 | Harris Todd | President and CEO | A | 265,000 | $0.0000 | $0.00 |
| May 5, 2026 | Harris Todd | President and CEO | A | 79,000 | $0.0000 | $0.00 |
| May 5, 2026 | Fuhrman Alan | Chief Financial Officer | A | 67,000 | $0.0000 | $0.00 |
| May 5, 2026 | Fuhrman Alan | Chief Financial Officer | A | 20,000 | $0.0000 | $0.00 |
| May 5, 2026 | Warner Douglas J | Chief Medical Officer | A | 85,000 | $0.0000 | $0.00 |
| May 5, 2026 | Warner Douglas J | Chief Medical Officer | A | 25,000 | $0.0000 | $0.00 |
| Apr 16, 2026 | Dable Habib J | Director | A | 44,400 | $0.0000 | $0.00 |
| Mar 26, 2026 | KAPLAN GILLA | Director | M | 53,172 | $0.0000 | $0.00 |
| Mar 26, 2026 | KAPLAN GILLA | Director | D | 53,172 | $37.7483 | $2.01M |
| Mar 26, 2026 | KAPLAN GILLA | Director | M | 53,172 | $2.2500 | $119.64K |
| Mar 25, 2026 | KAPLAN GILLA | Director | M | 14,295 | $0.0000 | $0.00 |
| Mar 25, 2026 | KAPLAN GILLA | Director | S | 14,295 | $36.9714 | $528.51K |
| Mar 25, 2026 | KAPLAN GILLA | Director | M | 14,295 | $2.2500 | $32.16K |
| Mar 13, 2026 | Harris Todd | President and CEO | A | 1,463 | $9.1290 | $13.36K |
| Mar 13, 2026 | Fuhrman Alan | Chief Financial Officer | A | 1,376 | $9.1290 | $12.56K |
| Feb 12, 2026 | Bensen Daniel | Chief Discovery Officer | S | 5,872 | $33.3666 | $195.93K |
| Feb 12, 2026 | Bensen Daniel | Chief Discovery Officer | S | 2,128 | $31.5018 | $67.03K |
| Jan 12, 2026 | Bensen Daniel | Chief Discovery Officer | S | 1,017 | $29.0808 | $29.57K |
| Jan 12, 2026 | Bensen Daniel | Chief Discovery Officer | S | 6,983 | $28.4420 | $198.61K |
| Dec 19, 2025 | MORE ROBERT J | Director | S | 10,000 | $25.0000 | $250.00K |
| Dec 12, 2025 | Bensen Daniel | Chief Discovery Officer | S | 8,000 | $22.6449 | $181.16K |
| Dec 1, 2025 | Ashar Bhavesh | Chief Operating Officer | A | 300,000 | $0.0000 | $0.00 |
| Nov 21, 2025 | MORE ROBERT J | Director | S | 246,871 | $20.2536 | $5.00M |
| Nov 19, 2025 | Bensen Daniel | Chief Operating Officer | S | 49,956 | $16.3203 | $815.30K |
| Nov 18, 2025 | Bensen Daniel | Chief Operating Officer | S | 75,633 | $16.0727 | $1.22M |
| Nov 17, 2025 | Bensen Daniel | Chief Operating Officer | S | 1,500 | $17.0713 | $25.61K |
| Nov 17, 2025 | Bensen Daniel | Chief Operating Officer | S | 18,572 | $16.1098 | $299.19K |
| Nov 14, 2025 | Bensen Daniel | Chief Operating Officer | S | 110,228 | $16.0167 | $1.77M |
| Nov 13, 2025 | Bensen Daniel | Chief Operating Officer | S | 1,111 | $16.0036 | $17.78K |
| Sep 15, 2025 | Fuhrman Alan | Chief Financial Officer | A | 701 | $9.1290 | $6.40K |
| Aug 7, 2025 | Harris Todd | President and CEO | A | 570,000 | $0.0000 | $0.00 |
| Aug 7, 2025 | Warner Douglas J | Chief Medical Officer | A | 200,000 | $0.0000 | $0.00 |
| Aug 7, 2025 | Bensen Daniel | Chief Operating Officer | A | 170,000 | $0.0000 | $0.00 |
| Aug 7, 2025 | Fuhrman Alan | Chief Financial Officer | A | 170,000 | $0.0000 | $0.00 |
| Jun 18, 2025 | KAPLAN GILLA | Director | S | 9,568 | $9.7822 | $93.60K |
| Jun 17, 2025 | KAPLAN GILLA | Director | S | 10 | $10.3500 | $103.00 |
| Jun 16, 2025 | KAPLAN GILLA | Director | S | 6,814 | $10.3795 | $70.72K |
| Jun 16, 2025 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | P | 11,813 | $10.1300 | $119.67K |
| Jun 13, 2025 | KAPLAN GILLA | Director | S | 15,000 | $10.3055 | $154.58K |