First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
NEA Management Company, LLCCIK 0001512848 | 24,471,264 | $133.61M | – | no_change |
Bain Capital Life Sciences Investors, LLCCIK 0001703031 | 17,600,621 | $96.10M | – | no_change |
Venrock Adviser, LLCCIK 0001615982 | 13,740,375 | $75.02M | – | no_change |
DEERFIELD MANAGEMENT COMPANY, L.P.CIK 0001009258 | 13,569,000 | $74.09M | – | no_change |
TCG Crossover Management, LLCCIK 0001839948 | 12,362,205 | $67.50M | – | no_change |
BlackRock, Inc.CIK 0002012383 | 11,291,185 | $61.65M | +193,896 | ↑ INC |
Frazier Life Sciences Management, L.P.CIK 0001892134 | 9,720,852 | $53.08M | -141,449 | ↓ DEC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 7,783,913 | $42.50M | +7,783,913 | NEW |
STATE STREET CORPCIK 0000093751 | 6,707,684 | $36.62M | +2,374,662 | ↑ INC |
RTW INVESTMENTS, LPCIK 0001493215 | 5,952,380 | $32.50M | – | no_change |
MARSHALL WACE, LLPCIK 0001318757 | 4,514,348 | $24.65M | -45,573 | ↓ DEC |
Woodline Partners LPCIK 0001784547 | 4,245,119 | $23.18M | +479 | ↑ INC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 3,594,480 | $19.63M | +176,711 | ↑ INC |
Spruce Street Capital LPCIK 0002050194 | 3,383,175 | $18.47M | +972,082 | ↑ INC |
EMERALD ADVISERS, LLCCIK 0001015083 | 3,371,285 | $18.41M | -124,211 | ↓ DEC |
Rosalind Advisors, Inc.CIK 0001622627 | 3,203,721 | $17.49M | -200,000 | ↓ DEC |
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219 | 2,710,723 | $14.80M | +35,792 | ↑ INC |
Vestal Point Capital, LPCIK 0001974915 | 2,600,052 | $14.20M | +994,052 | ↑ INC |
Affinity Asset Advisors, LLCCIK 0001773195 | 2,512,153 | $13.72M | -285,000 | ↓ DEC |
EMERALD MUTUAL FUND ADVISERS TRUSTCIK 0001352895 | 2,368,669 | $12.93M | -27,789 | ↓ DEC |
Pictet Asset Management Holding SACIK 0001993888 | 2,275,381 | $12.42M | +2,275,381 | NEW |
NAN FUNG TRINITY (HK) LtdCIK 0001781880 | 1,842,350 | $10.06M | +153,850 | ↑ INC |
MORGAN STANLEYCIK 0000895421 | 1,786,293 | $9.75M | -551,603 | ↓ DEC |
SUPERSTRING CAPITAL MANAGEMENT LPCIK 0001931118 | 1,585,977 | $8.66M | +590,624 | ↑ INC |
ADAR1 Capital Management, LLCCIK 0001940272 | 1,464,535 | $8.00M | +59,083 | ↑ INC |
| Filer | Δ Shares | Value |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +7,783,913 | $42.50M |
STATE STREET CORP↑ INC | +2,374,662 | $36.62M |
Pictet Asset Management Holding SANEW | +2,275,381 | $12.42M |
SILVERARC CAPITAL MANAGEMENT, LLCNEW | +1,430,982 | $7.81M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +1,375,477 | $7.51M |
VANGUARD FIDUCIARY TRUST CONEW | +1,004,747 | $5.49M |
Vestal Point Capital, LP↑ INC | +994,052 | $14.20M |
Spruce Street Capital LP↑ INC | +972,082 | $18.47M |
ALGERT GLOBAL LLC↑ INC | +784,666 | $4.72K |
ORBIMED ADVISORS LLCNEW | +635,000 | $3.47M |
| Filer | Δ Shares | Value |
|---|---|---|
MORGAN STANLEY↓ DEC | -551,603 | $9.75M |
Invesco Ltd.↓ DEC | -465,585 | $1.22M |
SUSQUEHANNA INTERNATIONAL GROUP, LLP↓ DEC | -446,857 | $713.62K |
SPHERA FUNDS MANAGEMENT LTD.↓ DEC | -439,000 | $4.04M |
Affinity Asset Advisors, LLC↓ DEC | -285,000 | $13.72M |
BARCLAYS PLC↓ DEC | -279,066 | $152.19K |
Rosalind Advisors, Inc.↓ DEC | -200,000 | $17.49M |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC↓ DEC | -168,951 | $287.84K |
Swedbank AB↓ DEC | -150,000 | $3.82M |
BALYASNY ASSET MANAGEMENT L.P.↓ DEC | -148,197 | $218.49K |