First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
RTW INVESTMENTS, LPCIK 0001493215 | 5,623,525 | $183.10M | +76,669 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 5,385,714 | $175.36M | +173,160 | ↑ INC |
FMR LLCCIK 0000315066 | 5,383,666 | $175.29M | -217,254 | ↓ DEC |
Lynx1 Capital Management LPCIK 0001910456 | 4,763,673 | $155.11M | -641,001 | ↓ DEC |
Redmile Group, LLCCIK 0001425738 | 4,164,120 | $135.58M | +130,050 | ↑ INC |
MORGAN STANLEYCIK 0000895421 | 3,423,280 | $111.46M | -122,878 | ↓ DEC |
BAKER BROS. ADVISORS LPCIK 0001263508 | 3,336,697 | $108.64M | – | no_change |
TORONTO DOMINION BANKCIK 0000947263 | 3,173,258 | $103.32M | – | no_change |
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219 | 3,095,700 | $100.80M | +2,359,901 | ↑ INC |
BVF INC/ILCIK 0001056807 | 2,547,557 | $82.95M | +281,883 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 2,355,603 | $76.70M | +2,355,603 | NEW |
STATE STREET CORPCIK 0000093751 | 2,276,512 | $74.12M | -221,537 | ↓ DEC |
Siren, L.L.C.CIK 0002005245 | 1,995,347 | $64.97M | -252,000 | ↓ DEC |
DEERFIELD MANAGEMENT COMPANY, L.P.CIK 0001009258 | 1,823,500 | $59.37M | – | no_change |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 1,322,260 | $43.06M | +156,115 | ↑ INC |
DIMENSIONAL FUND ADVISORS LPCIK 0000354204 | 989,936 | $32.23M | +162,797 | ↑ INC |
Assenagon Asset Management S.A.CIK 0001546007 | 907,015 | $29.53M | -320,708 | ↓ DEC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 830,702 | $27.05M | -312,035 | ↓ DEC |
MPM BioImpact LLCCIK 0001687078 | 767,038 | $24.97M | -3,251 | ↓ DEC |
Opaleye Management Inc.CIK 0001595855 | 700,000 | $22.79M | +5,000 | ↑ INC |
Troluce Capital Advisors LLCCIK 0001910321 | 652,800 | $21.26M | +652,800 | NEW |
BAILLIE GIFFORD & COCIK 0001088875 | 575,182 | $18.73M | +328,282 | ↑ INC |
BANK OF AMERICA CORP /DE/CIK 0000070858 | 543,095 | $17.68M | +336,931 | ↑ INC |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 512,141 | $16.68M | +451,093 | ↑ INC |
Candriam S.C.A.CIK 0001537014 | 502,020 | $16.35M | +55,330 | ↑ INC |
| Filer | Δ Shares | Value |
|---|---|---|
WELLINGTON MANAGEMENT GROUP LLP↑ INC | +2,359,901 | $100.80M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +2,355,603 | $76.70M |
PRICE T ROWE ASSOCIATES INC /MD/↑ INC | +1,561,837 | $62.98K |
Troluce Capital Advisors LLCNEW | +652,800 | $21.26M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +462,682 | $15.06M |
MILLENNIUM MANAGEMENT LLC↑ INC | +451,093 | $16.68M |
VANGUARD FIDUCIARY TRUST CONEW | +356,947 | $11.62M |
BANK OF AMERICA CORP /DE/↑ INC | +336,931 | $17.68M |
BAILLIE GIFFORD & CO↑ INC | +328,282 | $18.73M |
Artisan Partners Limited PartnershipNEW | +315,492 | $10.27M |
| Filer | Δ Shares | Value |
|---|---|---|
Lynx1 Capital Management LP↓ DEC | -641,001 | $155.11M |
Assenagon Asset Management S.A.↓ DEC | -320,708 | $29.53M |
GOLDMAN SACHS GROUP INC↓ DEC | -312,035 | $27.05M |
Caption Management, LLC↓ DEC | -266,926 | $7.66M |
Siren, L.L.C.↓ DEC | -252,000 | $64.97M |
STATE STREET CORP↓ DEC | -221,537 | $74.12M |
FMR LLC↓ DEC | -217,254 | $175.29M |
BARCLAYS PLC↓ DEC | -140,826 | $329.47K |
Rhenman & Partners Asset Management AB↓ DEC | -133,000 | $2.70M |
MORGAN STANLEY↓ DEC | -122,878 | $111.46M |