| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jul 7, 2026 | ORBIMED ADVISORS LLC | Director | S | 85,918 | $44.8600 | $3.85M |
| Jul 7, 2026 | Thompson Peter A. | Director | S | 85,918 | $44.8600 | $3.85M |
| Jul 6, 2026 | Fitzpatrick Jennifer | Chief Legal Officer | M | 10,250 | $0.0000 | $0.00 |
| Jul 6, 2026 | Fitzpatrick Jennifer | Chief Legal Officer | S | 10,250 | $43.5963 | $446.86K |
| Jul 6, 2026 | Fitzpatrick Jennifer | Chief Legal Officer | M | 10,250 | $6.1100 | $62.63K |
| Jun 30, 2026 | ORBIMED ADVISORS LLC | Director | S | 115,844 | $45.5000 | $5.27M |
| Jun 30, 2026 | Thompson Peter A. | Director | S | 115,844 | $45.5000 | $5.27M |
| Jun 17, 2026 | Booth Bruce | Director | A | 17,340 | $0.0000 | $0.00 |
| Jun 17, 2026 | Clancy Paul J | Director | A | 17,340 | $0.0000 | $0.00 |
| Jun 17, 2026 | Fleming Harold Edward | Director | A | 17,340 | $0.0000 | $0.00 |
| Jun 17, 2026 | Resnick Joshua | Director | A | 17,340 | $0.0000 | $0.00 |
| Jun 17, 2026 | Ruddy Marcella K. | Director | A | 17,340 | $0.0000 | $0.00 |
| Jun 17, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | A | 17,340 | $0.0000 | $0.00 |
| Jun 17, 2026 | Thompson Peter A. | Director | A | 17,340 | $0.0000 | $0.00 |
| Jun 17, 2026 | Viney Joanne L. | Director | A | 17,340 | $0.0000 | $0.00 |
| Jun 17, 2026 | Stelzer Laurie | Director | A | 17,340 | $0.0000 | $0.00 |
| May 27, 2026 | ORBIMED ADVISORS LLC | Director | S | 101 | $44.4900 | $4.49K |
| May 27, 2026 | Thompson Peter A. | Director | S | 101 | $44.4900 | $4.49K |
| May 11, 2026 | ORBIMED ADVISORS LLC | Director | S | 184,639 | $46.2200 | $8.53M |
| May 11, 2026 | Thompson Peter A. | Director | S | 184,639 | $46.2200 | $8.53M |
| May 8, 2026 | ORBIMED ADVISORS LLC | Director | S | 59,767 | $44.5800 | $2.66M |
| May 8, 2026 | Thompson Peter A. | Director | S | 59,767 | $44.5800 | $2.66M |
| May 7, 2026 | ORBIMED ADVISORS LLC | Director | S | 48,546 | $44.6100 | $2.17M |
| May 7, 2026 | Thompson Peter A. | Director | S | 48,546 | $44.6100 | $2.17M |
| Apr 18, 2026 | ORBIMED ADVISORS LLC | Director | S | 2,948 | $44.5200 | $131.24K |
| Apr 18, 2026 | Thompson Peter A. | Director | S | 2,948 | $44.5200 | $131.24K |
| Apr 17, 2026 | ORBIMED ADVISORS LLC | Director | S | 52,397 | $44.6800 | $2.34M |
| Apr 17, 2026 | Thompson Peter A. | Director | S | 52,397 | $44.6800 | $2.34M |
| Apr 16, 2026 | ORBIMED ADVISORS LLC | Director | S | 226,906 | $45.3400 | $10.29M |
| Apr 16, 2026 | Thompson Peter A. | Director | S | 226,906 | $45.3400 | $10.29M |
| Apr 15, 2026 | ORBIMED ADVISORS LLC | Director | S | 235,863 | $44.6400 | $10.53M |
| Apr 15, 2026 | Thompson Peter A. | Director | S | 235,863 | $44.6400 | $10.53M |
| Apr 14, 2026 | ORBIMED ADVISORS LLC | Director | S | 47,814 | $44.5100 | $2.13M |
| Apr 14, 2026 | Thompson Peter A. | Director | S | 47,814 | $44.5100 | $2.13M |
| Mar 5, 2026 | Fitzpatrick Jennifer | Chief Legal Officer | M | 10,250 | $0.0000 | $0.00 |
| Mar 5, 2026 | Fitzpatrick Jennifer | Chief Legal Officer | S | 10,250 | $33.8555 | $347.02K |
| Mar 5, 2026 | Fitzpatrick Jennifer | Chief Legal Officer | M | 10,250 | $6.1100 | $62.63K |
| Feb 3, 2026 | ORBIMED ADVISORS LLC | Director | S | 29,063 | $44.5800 | $1.30M |
| Feb 3, 2026 | Thompson Peter A. | Director | S | 29,063 | $44.5800 | $1.30M |
| Feb 2, 2026 | ORBIMED ADVISORS LLC | Director | S | 1,890 | $44.5700 | $84.24K |
| Feb 2, 2026 | Thompson Peter A. | Director | S | 1,890 | $44.5700 | $84.24K |
| Jan 22, 2026 | TPG GP A, LLC | 10% Owner | S | 250,000 | $40.0000 | $10.00M |
| Jan 2, 2026 | Ridloff Elena | CFO | A | 165,440 | $0.0000 | $0.00 |
| Jan 2, 2026 | Beer Caroline Stark | Chief Business Officer | A | 139,340 | $0.0000 | $0.00 |
| Jan 2, 2026 | Cloonan Michael | President & CEO | A | 436,100 | $0.0000 | $0.00 |
| Jan 2, 2026 | Fitzpatrick Jennifer | Chief Legal Officer | A | 103,140 | $0.0000 | $0.00 |
| Jan 2, 2026 | McKee Charlotte | Chief Medical Officer | A | 155,700 | $0.0000 | $0.00 |
| Dec 24, 2025 | Thompson Peter A. | Director | S | 33,356 | $44.5500 | $1.49M |
| Dec 24, 2025 | ORBIMED ADVISORS LLC | Director | S | 33,356 | $44.5500 | $1.49M |
| Dec 19, 2025 | ORBIMED ADVISORS LLC | Director | S | 875 | $44.4900 | $38.93K |