First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
BAKER BROS. ADVISORS LPCIK 0001263508 | 11,045,336 | $84.50M | – | no_change |
RTW INVESTMENTS, LPCIK 0001493215 | 7,356,916 | $56.28M | +216,564 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 6,239,239 | $47.73M | +169,606 | ↑ INC |
SUVRETTA CAPITAL MANAGEMENT, LLCCIK 0001569064 | 4,221,836 | $32.30M | +4,185,798 | ↑ INC |
STATE STREET CORPCIK 0000093751 | 3,782,237 | $28.93M | +89,130 | ↑ INC |
FCPM III SERVICES B.V.CIK 0002013410 | 2,808,368 | $21.48M | – | no_change |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 2,759,120 | $21.11M | +2,759,120 | NEW |
SUSQUEHANNA INTERNATIONAL GROUP, LLPCIK 0001446194 | 2,320,879 | $17.75M | +336,435 | ↑ INC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 2,277,276 | $17.42M | +1,619,180 | ↑ INC |
FMR LLCCIK 0000315066 | 2,045,490 | $15.65M | -936,090 | ↓ DEC |
Erste Asset Management GmbHCIK 0002024532 | 2,120,000 | $15.26M | – | no_change |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 1,801,525 | $13.79M | +51,331 | ↑ INC |
ADAR1 Capital Management, LLCCIK 0001940272 | 1,682,987 | $12.87M | +416,665 | ↑ INC |
TORONTO DOMINION BANKCIK 0000947263 | 1,591,030 | $12.17M | -638,497 | ↓ DEC |
Caption Management, LLCCIK 0001706766 | 1,424,422 | $10.90M | +210,852 | ↑ INC |
Boxer Capital Management, LLCCIK 0002018299 | 1,175,000 | $8.99M | +425,000 | ↑ INC |
DIMENSIONAL FUND ADVISORS LPCIK 0000354204 | 1,140,099 | $8.72M | +20,742 | ↑ INC |
Sofinnova Investments, Inc.CIK 0001631134 | 1,015,400 | $7.77M | -2,291,129 | ↓ DEC |
EcoR1 Capital, LLCCIK 0001587114 | 1,000,000 | $7.65M | +149,659 | ↑ INC |
CITADEL ADVISORS LLCCIK 0001423053 | 823,829 | $6.30M | +313,670 | ↑ INC |
DIADEMA PARTNERS LPCIK 0002026172 | 766,060 | $5.86M | +535,063 | ↑ INC |
JPMORGAN CHASE & COCIK 0000019617 | 789,951 | $5.69M | -135,222 | ↓ DEC |
Sio Capital Management, LLCCIK 0001482416 | 720,036 | $5.51M | +720,036 | NEW |
Jefferies Financial Group Inc.CIK 0000096223 | 714,225 | $5.46M | -1 | ↓ DEC |
JANE STREET GROUP, LLCCIK 0001595888 | 654,245 | $5.00M | -191,385 | ↓ DEC |
| Filer | Δ Shares | Value |
|---|---|---|
SUVRETTA CAPITAL MANAGEMENT, LLC↑ INC | +4,185,798 | $32.30M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +2,759,120 | $21.11M |
GOLDMAN SACHS GROUP INC↑ INC | +1,619,180 | $17.42M |
Sio Capital Management, LLCNEW | +720,036 | $5.51M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +552,576 | $4.23M |
DIADEMA PARTNERS LP↑ INC | +535,063 | $5.86M |
VANGUARD FIDUCIARY TRUST CONEW | +475,126 | $3.63M |
Boxer Capital Management, LLC↑ INC | +425,000 | $8.99M |
ADAR1 Capital Management, LLC↑ INC | +416,665 | $12.87M |
SUSQUEHANNA INTERNATIONAL GROUP, LLP↑ INC | +336,435 | $17.75M |
| Filer | Δ Shares | Value |
|---|---|---|
READYSTATE ASSET MANAGEMENT LP↓ DEC | -2,482,524 | $1.06M |
Sofinnova Investments, Inc.↓ DEC | -2,291,129 | $7.77M |
Ally Bridge Group (NY) LLC↓ DEC | -953,100 | $1.89M |
FMR LLC↓ DEC | -936,090 | $15.65M |
TORONTO DOMINION BANK↓ DEC | -638,497 | $12.17M |
MILLENNIUM MANAGEMENT LLC↓ DEC | -501,129 | $3.70M |
Invesco Ltd.↓ DEC | -422,090 | $1.46M |
NAN FUNG TRINITY (HK) Ltd↓ DEC | -379,200 | $1.50M |
BNP PARIBAS FINANCIAL MARKETS↓ DEC | -302,342 | $1.21M |
Jump Financial, LLC↓ DEC | -192,464 | $798.50K |