| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 9, 2026 | FRIEDMAN PAUL A | Director | A | 38,000 | $0.0000 | $0.00 |
| Jun 9, 2026 | Sandor Victor | Director | A | 38,000 | $0.0000 | $0.00 |
| Jun 9, 2026 | Bonita David P | Director, 10% Owner | A | 38,000 | $0.0000 | $0.00 |
| Jun 9, 2026 | Babler Martin | Director | A | 38,000 | $0.0000 | $0.00 |
| Jun 9, 2026 | Dorton Katina | Director | A | 38,000 | $0.0000 | $0.00 |
| Jun 9, 2026 | BAKER BROS. ADVISORS LP | Director, 10% Owner | A | 38,000 | $0.0000 | $0.00 |
| Jun 9, 2026 | BAKER BROS. ADVISORS LP | Director, 10% Owner | A | 38,000 | $0.0000 | $0.00 |
| May 1, 2026 | Morris Charles Q | Chief Medical Officer | A | 450,000 | $4.7000 | $2.12M |
| Apr 27, 2026 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | J | 1,407,000 | – | – |
| Apr 27, 2026 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | J | 1,407,000 | – | – |
| Apr 21, 2026 | BAKER BROS. ADVISORS LP | Director, 10% Owner | P | 2,137,651 | $4.4399 | $9.49M |
| Apr 21, 2026 | BAKER BROS. ADVISORS LP | Director, 10% Owner | P | 114,601 | $4.4399 | $508.82K |
| Apr 21, 2026 | ORBIMED ADVISORS LLC | Director, 10% Owner | P | 1,126,126 | $4.4400 | $5.00M |
| Apr 21, 2026 | ORBIMED ADVISORS LLC | Director, 10% Owner | P | 1,689,189 | $4.4400 | $7.50M |
| Apr 21, 2026 | Bonita David P | Director, 10% Owner | P | 1,126,126 | $4.4400 | $5.00M |
| Apr 21, 2026 | Bonita David P | Director, 10% Owner | P | 1,689,189 | $4.4400 | $7.50M |
| Feb 4, 2026 | Vaddi Krishna | CEO | A | 837,000 | $0.0000 | $0.00 |
| Feb 4, 2026 | Lim Bryant David | CLO, CFO, Corp Sec. | A | 275,000 | $0.0000 | $0.00 |
| Feb 4, 2026 | Scherle Peggy | Chief Scientific Officer | A | 230,000 | $0.0000 | $0.00 |
| Feb 4, 2026 | Combs Andrew | Chief Chemistry Officer | A | 230,000 | $0.0000 | $0.00 |
| Nov 5, 2025 | Sandor Victor | Director | A | 121,285 | $0.0000 | $0.00 |
| Oct 17, 2025 | Dorton Katina | Director | A | 76,000 | $0.0000 | $0.00 |
| Oct 4, 2025 | Huang Jane | President, CMO | M | 9,375 | $0.0000 | $0.00 |
| Oct 4, 2025 | Huang Jane | President, CMO | F | 3,355 | $1.4700 | $4.93K |
| Oct 4, 2025 | Huang Jane | President, CMO | M | 9,375 | – | – |
| Jul 4, 2025 | Huang Jane | President, CMO | M | 9,375 | $0.0000 | $0.00 |
| Jul 4, 2025 | Huang Jane | President, CMO | F | 3,355 | $0.7939 | $2.66K |
| Jul 4, 2025 | Huang Jane | President, CMO | M | 9,375 | – | – |
| Jun 12, 2025 | Babler Martin | Director | A | 38,000 | $0.0000 | $0.00 |
| Jun 12, 2025 | Bonita David P | Director, 10% Owner | A | 38,000 | $0.0000 | $0.00 |
| Jun 12, 2025 | FRIEDMAN PAUL A | Director | A | 38,000 | $0.0000 | $0.00 |
| Jun 12, 2025 | Dier Mardi | Director | A | 38,000 | $0.0000 | $0.00 |
| Jun 12, 2025 | Sandor Victor | Director | A | 38,000 | $0.0000 | $0.00 |
| Jun 12, 2025 | BAKER BROS. ADVISORS LP | Director, 10% Owner | A | 76,000 | $0.0000 | $0.00 |
| Jun 12, 2025 | BAKER BROS. ADVISORS LP | Director, 10% Owner | A | 76,000 | $0.0000 | $0.00 |
| Apr 4, 2025 | Huang Jane | President, CMO | M | 9,375 | $0.0000 | $0.00 |
| Apr 4, 2025 | Huang Jane | President, CMO | F | 3,355 | $0.6750 | $2.26K |
| Apr 4, 2025 | Huang Jane | President, CMO | M | 9,375 | – | – |
| Mar 25, 2025 | Vaddi Krishna | CEO | P | 675,000 | $0.6925 | $467.44K |
| Mar 25, 2025 | Combs Andrew | Chief Chemistry Officer | P | 100,000 | $0.6925 | $69.25K |
| Mar 21, 2025 | Vaddi Krishna | CEO | P | 15,000 | $0.7306 | $10.96K |
| Mar 20, 2025 | Vaddi Krishna | CEO | P | 5,416 | $0.7294 | $3.95K |
| Mar 17, 2025 | Vaddi Krishna | CEO | P | 9,106 | $0.7499 | $6.83K |
| Mar 14, 2025 | Vaddi Krishna | CEO | P | 29,999 | $0.7544 | $22.63K |
| Mar 13, 2025 | Vaddi Krishna | CEO | P | 50,000 | $0.7164 | $35.82K |
| Mar 12, 2025 | Vaddi Krishna | CEO | P | 47,500 | $0.7104 | $33.74K |
| Feb 4, 2025 | Vaddi Krishna | CEO | A | 496,000 | $0.0000 | $0.00 |
| Feb 4, 2025 | Huang Jane | President, CMO | A | 200,000 | $0.0000 | $0.00 |
| Feb 4, 2025 | Combs Andrew | Chief Chemistry Officer | A | 175,000 | $0.0000 | $0.00 |
| Feb 4, 2025 | Scherle Peggy | Chief Scientific Officer | A | 175,000 | $0.0000 | $0.00 |