First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
ORBIMED ADVISORS LLCCIK 0001055951 | 10,909,256 | $37.31M | – | no_change |
BAKER BROS. ADVISORS LPCIK 0001263508 | 10,123,824 | $34.62M | – | no_change |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 1,230,406 | $4.21M | +1,230,406 | NEW |
EcoR1 Capital, LLCCIK 0001587114 | 947,049 | $3.24M | -210,403 | ↓ DEC |
TWO SIGMA INVESTMENTS, LPCIK 0001179392 | 923,626 | $3.16M | +134,931 | ↑ INC |
SPHERA FUNDS MANAGEMENT LTD.CIK 0001496201 | 558,339 | $1.91M | +435,587 | ↑ INC |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 382,737 | $1.31M | +231,740 | ↑ INC |
MARSHALL WACE, LLPCIK 0001318757 | 358,906 | $1.23M | +85,023 | ↑ INC |
MORGAN STANLEYCIK 0000895421 | 322,161 | $1.10M | -12,755 | ↓ DEC |
BlackRock, Inc.CIK 0002012383 | 321,886 | $1.10M | +55,606 | ↑ INC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 302,458 | $1.03M | +29,572 | ↑ INC |
SUSQUEHANNA INTERNATIONAL GROUP, LLPCIK 0001446194 | 288,788 | $987.65K | +120,379 | ↑ INC |
RENAISSANCE TECHNOLOGIES LLCCIK 0001037389 | 275,200 | $941.18K | +3,900 | ↑ INC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 236,469 | $808.72K | +118,992 | ↑ INC |
JANE STREET GROUP, LLCCIK 0001595888 | 192,963 | $659.93K | +81,923 | ↑ INC |
VANGUARD FIDUCIARY TRUST COCIK 0000933478 | 157,380 | $538.24K | +157,380 | NEW |
ADAR1 Capital Management, LLCCIK 0001940272 | 152,825 | $522.66K | +152,825 | NEW |
STATE STREET CORPCIK 0000093751 | 138,231 | $472.75K | +10,939 | ↑ INC |
CITADEL ADVISORS LLCCIK 0001423053 | 124,378 | $425.37K | +90,753 | ↑ INC |
Connor, Clark & Lunn Investment Management Ltd.CIK 0001596800 | 109,085 | $373.07K | +62,995 | ↑ INC |
UBS Group AGCIK 0001610520 | 64,505 | $220.61K | +62,648 | ↑ INC |
XTX Topco LtdCIK 0001828301 | 57,190 | $195.59K | +7,031 | ↑ INC |
BANK OF AMERICA CORP /DE/CIK 0000070858 | 56,525 | $193.32K | +46,717 | ↑ INC |
BRIDGEWAY CAPITAL MANAGEMENT, LLCCIK 0001107261 | 53,500 | $182.97K | – | no_change |
NORTHERN TRUST CORPCIK 0000073124 | 50,120 | $171.41K | – | no_change |
| Filer | Δ Shares | Value |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +1,230,406 | $4.21M |
SPHERA FUNDS MANAGEMENT LTD.↑ INC | +435,587 | $1.91M |
MILLENNIUM MANAGEMENT LLC↑ INC | +231,740 | $1.31M |
VANGUARD FIDUCIARY TRUST CONEW | +157,380 | $538.24K |
ADAR1 Capital Management, LLCNEW | +152,825 | $522.66K |
TWO SIGMA INVESTMENTS, LP↑ INC | +134,931 | $3.16M |
SUSQUEHANNA INTERNATIONAL GROUP, LLP↑ INC | +120,379 | $987.65K |
GOLDMAN SACHS GROUP INC↑ INC | +118,992 | $808.72K |
CITADEL ADVISORS LLC↑ INC | +90,753 | $425.37K |
MARSHALL WACE, LLP↑ INC | +85,023 | $1.23M |
| Filer | Δ Shares | Value |
|---|---|---|
EcoR1 Capital, LLC↓ DEC | -210,403 | $3.24M |
Point72 Asset Management, L.P.↓ DEC | -42,839 | $55.84K |
OMERS ADMINISTRATION Corp↓ DEC | -40,300 | $111.83K |
ACADIAN ASSET MANAGEMENT LLC↓ DEC | -24,184 | $1.75K |
MORGAN STANLEY↓ DEC | -12,755 | $1.10M |
Qube Research & Technologies Ltd↓ DEC | -5,134 | $56.15K |
CALDWELL SUTTER CAPITAL, INC.↓ DEC | -1,000 | $3.42K |
FMR LLC↓ DEC | -143 | $20.55K |
CWM, LLC↓ DEC | -119 | $1.96K |
SBI Securities Co., Ltd.↓ DEC | -100 | $9.03K |