First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
Frazier Life Sciences Management, L.P.CIK 0001892134 | 12,466,489 | $138.50M | – | no_change |
Medicxi Ventures Management (Jersey) LtdCIK 0001715579 | 7,464,572 | $82.93M | – | no_change |
Invesco Ltd.CIK 0000914208 | 4,322,060 | $48.02M | +401,614 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 4,061,996 | $45.13M | +506,448 | ↑ INC |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 4,022,909 | $44.69M | +1,940,729 | ↑ INC |
Carlyle Group Inc.CIK 0001527166 | 3,496,808 | $38.85M | – | no_change |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 2,583,636 | $28.70M | +2,583,636 | NEW |
NEA Management Company, LLCCIK 0001512848 | 1,960,169 | $21.78M | – | no_change |
683 Capital Management, LLCCIK 0001404574 | 1,850,000 | $20.55M | +65,000 | ↑ INC |
Ensign Peak Advisors, IncCIK 0001454984 | 1,627,806 | $18.08M | -724,214 | ↓ DEC |
Catalys Pacific, LLCCIK 0002011385 | 1,493,854 | $16.60M | +64,840 | ↑ INC |
STATE STREET CORPCIK 0000093751 | 1,386,890 | $15.41M | +237,354 | ↑ INC |
WASATCH ADVISORS LPCIK 0000814133 | 1,340,916 | $14.90M | +9,247 | ↑ INC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 1,328,045 | $14.76M | +254,611 | ↑ INC |
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.CIK 0000921739 | 1,205,369 | $13.39M | +1,205,369 | NEW |
SummitTX Capital, L.P.CIK 0002052310 | 995,885 | $11.06M | +478,065 | ↑ INC |
FRANKLIN RESOURCES INCCIK 0000038777 | 994,504 | $11.05M | +994,504 | NEW |
PERCEPTIVE ADVISORS LLCCIK 0001224962 | 925,000 | $10.28M | +925,000 | NEW |
CITADEL ADVISORS LLCCIK 0001423053 | 918,158 | $10.20M | +507,943 | ↑ INC |
MARSHALL WACE, LLPCIK 0001318757 | 860,692 | $9.56M | +545,819 | ↑ INC |
Propel Bio Management, LLCCIK 0001969764 | 841,272 | $9.35M | +100,354 | ↑ INC |
VANGUARD PORTFOLIO MANAGEMENT LLCCIK 0002100121 | 666,029 | $7.40M | +666,029 | NEW |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 626,196 | $6.96M | +234,151 | ↑ INC |
EcoR1 Capital, LLCCIK 0001587114 | 625,000 | $6.94M | +426,520 | ↑ INC |
TWO SIGMA INVESTMENTS, LPCIK 0001179392 | 482,136 | $5.36M | +424,353 | ↑ INC |
| Filer | Δ Shares | Value |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +2,583,636 | $28.70M |
MILLENNIUM MANAGEMENT LLC↑ INC | +1,940,729 | $44.69M |
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.NEW | +1,205,369 | $13.39M |
FRANKLIN RESOURCES INCNEW | +994,504 | $11.05M |
PERCEPTIVE ADVISORS LLCNEW | +925,000 | $10.28M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +666,029 | $7.40M |
MARSHALL WACE, LLP↑ INC | +545,819 | $9.56M |
CITADEL ADVISORS LLC↑ INC | +507,943 | $10.20M |
BlackRock, Inc.↑ INC | +506,448 | $45.13M |
SummitTX Capital, L.P.↑ INC | +478,065 | $11.06M |
| Filer | Δ Shares | Value |
|---|---|---|
Ensign Peak Advisors, Inc↓ DEC | -724,214 | $18.08M |
Catalio Capital Management, LP↓ DEC | -451,229 | $2.75M |
SUSQUEHANNA INTERNATIONAL GROUP, LLP↓ DEC | -427,592 | $5.09M |
JANE STREET GROUP, LLC↓ DEC | -320,670 | $979.90K |
Brevan Howard Capital Management LP↓ DEC | -182,351 | $1.05M |
BALYASNY ASSET MANAGEMENT L.P.↓ DEC | -111,784 | $1.06M |
GROUP ONE TRADING LLC↓ DEC | -86,745 | $188.19K |
HUSSMAN STRATEGIC ADVISORS, INC.↓ DEC | -63,000 | $933.24K |
Simplify Asset Management Inc.↓ DEC | -59,549 | $2.92M |
BARCLAYS PLC↓ DEC | -59,502 | $281.72K |