| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 23, 2026 | Wang Lai | President, Global Head of R&D | S | 1,068 | $276.7350 | $295.55K |
| Jun 23, 2026 | OYLER JOHN | Chief Executive Officer | S | 320 | $275.0950 | $88.03K |
| Jun 23, 2026 | OYLER JOHN | Chief Executive Officer | S | 1,290 | $274.1186 | $353.61K |
| Jun 23, 2026 | OYLER JOHN | Chief Executive Officer | S | 1,800 | $273.3049 | $491.95K |
| Jun 23, 2026 | Wu Xiaobin | President and COO | S | 1,292 | $276.2592 | $356.93K |
| Jun 16, 2026 | OYLER JOHN | Chief Executive Officer | S | 333 | $266.6947 | $88.81K |
| Jun 16, 2026 | OYLER JOHN | Chief Executive Officer | S | 1,710 | $265.9856 | $454.83K |
| Jun 16, 2026 | OYLER JOHN | Chief Executive Officer | S | 1,650 | $264.8738 | $437.04K |
| Jun 16, 2026 | Wang Lai | President, Global Head of R&D | S | 1,169 | $265.3857 | $310.24K |
| Jun 16, 2026 | Lee Chan Henry | SVP, General Counsel | S | 590 | $265.9750 | $156.93K |
| Jun 16, 2026 | Wu Xiaobin | President and COO | S | 1,357 | $266.7626 | $362.00K |
| Jun 11, 2026 | BAKER BROS. ADVISORS LP | Director | A | 18,980 | $0.0000 | $0.00 |
| Jun 11, 2026 | BAKER BROS. ADVISORS LP | Director | A | 18,980 | $0.0000 | $0.00 |
| Jun 11, 2026 | Sawyers Charles Lazelle | Director | A | 18,980 | $0.0000 | $0.00 |
| Jun 11, 2026 | Riva Alessandro | Director | A | 18,980 | $0.0000 | $0.00 |
| Jun 11, 2026 | Sharp Shalini | Director | A | 18,980 | $0.0000 | $0.00 |
| Jun 11, 2026 | Dugan Margaret | Director | A | 18,980 | $0.0000 | $0.00 |
| Jun 11, 2026 | Mooney Elizabeth Fisher | Director | A | 18,980 | $0.0000 | $0.00 |
| Jun 11, 2026 | BRANDICOURT OLIVIER | Director | A | 18,980 | $0.0000 | $0.00 |
| Jun 11, 2026 | HOOPER ANTHONY C | Director | A | 18,980 | $0.0000 | $0.00 |
| Jun 11, 2026 | Lee Chan Henry | SVP, General Counsel | A | 87,308 | $0.0000 | $0.00 |
| Jun 11, 2026 | Lee Chan Henry | SVP, General Counsel | S | 428 | $257.6350 | $110.27K |
| Jun 11, 2026 | Lee Chan Henry | SVP, General Counsel | A | 45,071 | $0.0000 | $0.00 |
| Jun 11, 2026 | Wu Xiaobin | President and COO | A | 229,775 | $0.0000 | $0.00 |
| Jun 11, 2026 | Wu Xiaobin | President and COO | S | 626 | $261.2017 | $163.51K |
| Jun 11, 2026 | Wu Xiaobin | President and COO | A | 118,625 | $0.0000 | $0.00 |
| Jun 11, 2026 | OYLER JOHN | Chief Executive Officer | A | 344,669 | $0.0000 | $0.00 |
| Jun 11, 2026 | OYLER JOHN | Chief Executive Officer | S | 149 | $258.8100 | $38.56K |
| Jun 11, 2026 | OYLER JOHN | Chief Executive Officer | S | 200 | $258.2792 | $51.66K |
| Jun 11, 2026 | OYLER JOHN | Chief Executive Officer | S | 859 | $257.5915 | $221.27K |
| Jun 11, 2026 | OYLER JOHN | Chief Executive Officer | S | 741 | $256.2282 | $189.87K |
| Jun 11, 2026 | OYLER JOHN | Chief Executive Officer | A | 177,931 | $0.0000 | $0.00 |
| Jun 11, 2026 | Wang Xiaodong | Director, Other | A | 193,492 | $0.0000 | $0.00 |
| Jun 11, 2026 | Wang Xiaodong | Director, Other | A | 99,892 | $0.0000 | $0.00 |
| Jun 11, 2026 | Rosenberg Aaron | Chief Financial Officer | A | 137,865 | $0.0000 | $0.00 |
| Jun 11, 2026 | Rosenberg Aaron | Chief Financial Officer | S | 631 | $257.7441 | $162.64K |
| Jun 11, 2026 | Rosenberg Aaron | Chief Financial Officer | A | 71,175 | $0.0000 | $0.00 |
| Jun 11, 2026 | Ball Titus B. | Principal Accounting Officer | S | 120 | $257.5300 | $30.90K |
| Jun 11, 2026 | Ball Titus B. | Principal Accounting Officer | S | 49 | $256.3870 | $12.56K |
| Jun 11, 2026 | Ball Titus B. | Principal Accounting Officer | A | 31,213 | $0.0000 | $0.00 |
| Jun 11, 2026 | Wang Lai | President, Global Head of R&D | A | 229,775 | $0.0000 | $0.00 |
| Jun 11, 2026 | Wang Lai | President, Global Head of R&D | S | 756 | $261.0021 | $197.32K |
| Jun 11, 2026 | Wang Lai | President, Global Head of R&D | A | 118,625 | $0.0000 | $0.00 |
| Jun 8, 2026 | OYLER JOHN | Chief Executive Officer | S | 1,120 | $271.1411 | $303.68K |
| Jun 8, 2026 | OYLER JOHN | Chief Executive Officer | S | 3,820 | $270.3847 | $1.03M |
| Jun 8, 2026 | Wu Xiaobin | President and COO | S | 40 | $270.5500 | $10.82K |
| Jun 8, 2026 | Wu Xiaobin | President and COO | S | 1,444 | $269.3325 | $388.92K |
| Jun 8, 2026 | Wang Lai | President, Global Head of R&D | S | 40 | $270.7300 | $10.83K |
| Jun 8, 2026 | Wang Lai | President, Global Head of R&D | S | 1,327 | $269.3426 | $357.42K |
| Jun 8, 2026 | Lee Chan Henry | SVP, General Counsel | S | 160 | $271.2575 | $43.40K |