First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
Catalys Pacific, LLCCIK 0002011385 | 7,903,838 | $214.11M | – | no_change |
Samsara BioCapital, LLCCIK 0001744967 | 5,871,018 | $159.05M | – | no_change |
FMR LLCCIK 0000315066 | 4,861,104 | $131.69M | -196,405 | ↓ DEC |
BlackRock, Inc.CIK 0002012383 | 4,481,582 | $121.41M | +153,904 | ↑ INC |
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219 | 3,359,068 | $91.00M | +2,574,801 | ↑ INC |
Caption Management, LLCCIK 0001706766 | 3,273,400 | $88.68M | +824,200 | ↑ INC |
STATE STREET CORPCIK 0000093751 | 2,935,940 | $79.53M | -249,059 | ↓ DEC |
Caligan Partners LPCIK 0001727492 | 2,772,654 | $75.11M | -2,298,400 | ↓ DEC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 2,454,363 | $66.49M | +2,454,363 | NEW |
Laurion Capital Management LPCIK 0001390202 | 2,232,040 | $60.47M | +518,555 | ↑ INC |
ORBIMED ADVISORS LLCCIK 0001055951 | 2,052,900 | $55.61M | +1,072,500 | ↑ INC |
Point72 Asset Management, L.P.CIK 0001603466 | 1,911,433 | $51.78M | +704,213 | ↑ INC |
FRANKLIN RESOURCES INCCIK 0000038777 | 1,784,662 | $48.35M | -4,085 | ↓ DEC |
BOOTHBAY FUND MANAGEMENT, LLCCIK 0001549230 | 1,721,628 | $46.64M | +9,646 | ↑ INC |
Andera PartnersCIK 0001757283 | 1,591,917 | $43.13M | – | no_change |
SR ONE CAPITAL MANAGEMENT, LPCIK 0001910264 | 1,563,966 | $42.37M | – | no_change |
SUVRETTA CAPITAL MANAGEMENT, LLCCIK 0001569064 | 1,538,662 | $41.68M | – | no_change |
SUSQUEHANNA INTERNATIONAL GROUP, LLPCIK 0001446194 | 1,434,270 | $38.85M | +236,562 | ↑ INC |
SPHERA FUNDS MANAGEMENT LTD.CIK 0001496201 | 1,339,971 | $36.30M | +890,968 | ↑ INC |
ALLIANCEBERNSTEIN L.P.CIK 0001109448 | 975,961 | $35.42M | +53,445 | ↑ INC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 1,301,135 | $35.25M | +43,553 | ↑ INC |
JENNISON ASSOCIATES LLCCIK 0000053417 | 1,266,174 | $34.30M | +7,521 | ↑ INC |
ARMISTICE CAPITAL, LLCCIK 0001601086 | 1,176,000 | $31.86M | +499,965 | ↑ INC |
BANK OF AMERICA CORP /DE/CIK 0000070858 | 1,100,372 | $29.81M | +113,092 | ↑ INC |
Pictet Asset Management Holding SACIK 0001993888 | 1,034,438 | $28.02M | +181,555 | ↑ INC |
| Filer | Δ Shares | Value |
|---|---|---|
WELLINGTON MANAGEMENT GROUP LLP↑ INC | +2,574,801 | $91.00M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +2,454,363 | $66.49M |
ORBIMED ADVISORS LLC↑ INC | +1,072,500 | $55.61M |
SPHERA FUNDS MANAGEMENT LTD.↑ INC | +890,968 | $36.30M |
Caption Management, LLC↑ INC | +824,200 | $88.68M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +706,658 | $19.14M |
Point72 Asset Management, L.P.↑ INC | +704,213 | $51.78M |
Troluce Capital Advisors LLCNEW | +655,000 | $17.74M |
Laurion Capital Management LP↑ INC | +518,555 | $60.47M |
ARMISTICE CAPITAL, LLC↑ INC | +499,965 | $31.86M |
| Filer | Δ Shares | Value |
|---|---|---|
Caligan Partners LP↓ DEC | -2,298,400 | $75.11M |
GOLDMAN SACHS GROUP INC↓ DEC | -631,990 | $22.19M |
Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.↓ DEC | -554,115 | $2.84M |
TWO SIGMA INVESTMENTS, LP↓ DEC | -298,915 | $8.44M |
STATE STREET CORP↓ DEC | -249,059 | $79.53M |
MARSHALL WACE, LLP↓ DEC | -240,143 | $243.46K |
FMR LLC↓ DEC | -196,405 | $131.69M |
BARCLAYS PLC↓ DEC | -189,406 | $917.73K |
BNP PARIBAS FINANCIAL MARKETS↓ DEC | -156,213 | $452.84K |
Squarepoint Ops LLC↓ DEC | -141,313 | $2.86M |