First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
ARCH Venture Management, LLCCIK 0001274403 | 3,247,162 | $65.14M | +488,090 | ↑ INC |
GSK plcCIK 0001131399 | 1,512,659 | $30.34M | – | no_change |
Foresite Capital Management IV, LLCCIK 0001704132 | 800,399 | $16.06M | – | no_change |
Orland Properties LtdCIK 0001550093 | 754,698 | $15.14M | – | no_change |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 718,155 | $14.41M | +718,155 | NEW |
Almitas Capital LLCCIK 0001596468 | 577,807 | $11.59M | – | no_change |
Foresite Capital Management V, LLCCIK 0001792206 | 477,078 | $9.57M | – | no_change |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 458,905 | $9.21M | +400,254 | ↑ INC |
CITADEL ADVISORS LLCCIK 0001423053 | 393,462 | $7.89M | +52,761 | ↑ INC |
venBio Partners LLCCIK 0001776382 | 337,697 | $6.77M | – | no_change |
SUSQUEHANNA INTERNATIONAL GROUP, LLPCIK 0001446194 | 310,198 | $6.22M | +150,782 | ↑ INC |
Alphabet Inc.CIK 0001652044 | 293,256 | $5.88M | – | no_change |
BlackRock, Inc.CIK 0002012383 | 191,820 | $3.85M | +9,983 | ↑ INC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 166,980 | $3.35M | +3,983 | ↑ INC |
MARSHALL WACE, LLPCIK 0001318757 | 148,516 | $2.98M | +75,201 | ↑ INC |
RENAISSANCE TECHNOLOGIES LLCCIK 0001037389 | 116,411 | $2.34M | +76,921 | ↑ INC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 114,491 | $2.30M | +17,816 | ↑ INC |
Velan Capital Investment Management LPCIK 0001848809 | 102,000 | $2.05M | +102,000 | NEW |
MIC Capital Management UK LLPCIK 0001889830 | 87,028 | $1.75M | – | no_change |
VANGUARD FIDUCIARY TRUST COCIK 0000933478 | 86,925 | $1.74M | +86,925 | NEW |
CHARLES SCHWAB INVESTMENT MANAGEMENT INCCIK 0000884546 | 85,971 | $1.72M | +548 | ↑ INC |
Opaleye Management Inc.CIK 0001595855 | 79,097 | $1.59M | +79,097 | NEW |
STATE STREET CORPCIK 0000093751 | 72,522 | $1.45M | +21,050 | ↑ INC |
JANE STREET GROUP, LLCCIK 0001595888 | 63,893 | $1.28M | +51,484 | ↑ INC |
MORGAN STANLEYCIK 0000895421 | 56,151 | $1.13M | +13,202 | ↑ INC |
| Filer | Δ Shares | Value |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +718,155 | $14.41M |
ARCH Venture Management, LLC↑ INC | +488,090 | $65.14M |
MILLENNIUM MANAGEMENT LLC↑ INC | +400,254 | $9.21M |
SUSQUEHANNA INTERNATIONAL GROUP, LLP↑ INC | +150,782 | $6.22M |
Velan Capital Investment Management LPNEW | +102,000 | $2.05M |
VANGUARD FIDUCIARY TRUST CONEW | +86,925 | $1.74M |
Opaleye Management Inc.NEW | +79,097 | $1.59M |
RENAISSANCE TECHNOLOGIES LLC↑ INC | +76,921 | $2.34M |
MARSHALL WACE, LLP↑ INC | +75,201 | $2.98M |
CITADEL ADVISORS LLC↑ INC | +52,761 | $7.89M |
| Filer | Δ Shares | Value |
|---|---|---|
RBF Capital, LLC↓ DEC | -30,491 | $884.53K |
BARCLAYS PLC↓ DEC | -14,296 | $33.52K |
Walleye Capital LLC↓ DEC | -7,023 | $445.47K |
TWO SIGMA INVESTMENTS, LP↓ DEC | -4,031 | $232.40K |
GROUP ONE TRADING LLC↓ DEC | -3,500 | $74.22K |
CANADA PENSION PLAN INVESTMENT BOARD↓ DEC | -2,700 | $589.99K |
BNP PARIBAS FINANCIAL MARKETS↓ DEC | -1,073 | $42.07K |
JPMORGAN CHASE & CO↓ DEC | -148 | $28.32K |
GROUP ONE TRADING LLC↓ DEC | -100 | $20.06K |
CWM, LLC↓ DEC | -18 | $40.00 |