First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
Paradigm Biocapital Advisors LPCIK 0001855655 | 6,184,134 | $35.50M | +1,420,936 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 5,110,871 | $29.34M | +203,308 | ↑ INC |
Affinity Asset Advisors, LLCCIK 0001773195 | 5,050,211 | $28.99M | +1,850,211 | ↑ INC |
Vestal Point Capital, LPCIK 0001974915 | 4,475,000 | $25.69M | – | no_change |
Frazier Life Sciences Management, L.P.CIK 0001892134 | 4,424,725 | $25.40M | – | no_change |
CITADEL ADVISORS LLCCIK 0001423053 | 3,845,699 | $22.07M | +71,382 | ↑ INC |
ORBIMED ADVISORS LLCCIK 0001055951 | 3,602,450 | $20.68M | +1,477,450 | ↑ INC |
STATE STREET CORPCIK 0000093751 | 3,568,242 | $20.48M | +380,520 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 3,007,093 | $17.26M | +3,007,093 | NEW |
Woodline Partners LPCIK 0001784547 | 2,750,532 | $15.79M | -447,228 | ↓ DEC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 1,949,885 | $11.19M | +1,168,030 | ↑ INC |
Avoro Capital Advisors LLCCIK 0001633313 | 1,875,000 | $10.76M | -1,425,000 | ↓ DEC |
Point72 Asset Management, L.P.CIK 0001603466 | 1,680,449 | $9.65M | -214,273 | ↓ DEC |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 1,612,780 | $9.26M | +704,756 | ↑ INC |
BALYASNY ASSET MANAGEMENT L.P.CIK 0001218710 | 1,589,585 | $9.12M | -45,441 | ↓ DEC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 1,513,777 | $8.69M | +67,890 | ↑ INC |
ADAR1 Capital Management, LLCCIK 0001940272 | 1,467,350 | $8.42M | +74,189 | ↑ INC |
SUVRETTA CAPITAL MANAGEMENT, LLCCIK 0001569064 | 1,250,000 | $7.17M | – | no_change |
683 Capital Management, LLCCIK 0001404574 | 1,200,000 | $6.89M | +80,000 | ↑ INC |
DIMENSIONAL FUND ADVISORS LPCIK 0000354204 | 1,103,584 | $6.33M | +240,692 | ↑ INC |
Octagon Capital Advisors LPCIK 0001839435 | 1,100,000 | $6.31M | -625,000 | ↓ DEC |
Spruce Street Capital LPCIK 0002050194 | 928,593 | $5.33M | +753,593 | ↑ INC |
Blackstone Inc.CIK 0001393818 | 904,959 | $5.19M | – | no_change |
VANGUARD PORTFOLIO MANAGEMENT LLCCIK 0002100121 | 577,192 | $3.31M | +577,192 | NEW |
Ikarian Capital, LLCCIK 0001778253 | 513,011 | $2.94M | – | no_change |
| Filer | Δ Shares | Value |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +3,007,093 | $17.26M |
Affinity Asset Advisors, LLC↑ INC | +1,850,211 | $28.99M |
ORBIMED ADVISORS LLC↑ INC | +1,477,450 | $20.68M |
Paradigm Biocapital Advisors LP↑ INC | +1,420,936 | $35.50M |
GOLDMAN SACHS GROUP INC↑ INC | +1,168,030 | $11.19M |
Spruce Street Capital LP↑ INC | +753,593 | $5.33M |
MILLENNIUM MANAGEMENT LLC↑ INC | +704,756 | $9.26M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +577,192 | $3.31M |
VANGUARD FIDUCIARY TRUST CONEW | +384,734 | $2.21M |
STATE STREET CORP↑ INC | +380,520 | $20.48M |
| Filer | Δ Shares | Value |
|---|---|---|
Avoro Capital Advisors LLC↓ DEC | -1,425,000 | $10.76M |
Octagon Capital Advisors LP↓ DEC | -625,000 | $6.31M |
Woodline Partners LP↓ DEC | -447,228 | $15.79M |
Invesco Ltd.↓ DEC | -399,511 | $364.59K |
TWO SIGMA INVESTMENTS, LP↓ DEC | -218,891 | $1.04M |
Point72 Asset Management, L.P.↓ DEC | -214,273 | $9.65M |
BARCLAYS PLC↓ DEC | -176,589 | $69.83K |
JANE STREET GROUP, LLC↓ DEC | -115,196 | $142.93K |
Y-Intercept (Hong Kong) Ltd↓ DEC | -88,592 | $818.36K |
WELLS FARGO & COMPANY/MN↓ DEC | -45,743 | $143.46K |