First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
FMR LLCCIK 0000315066 | 11,699,950 | $974.49M | +2,771,376 | ↑ INC |
BAKER BROS. ADVISORS LPCIK 0001263508 | 8,657,242 | $721.06M | – | no_change |
Avoro Capital Advisors LLCCIK 0001633313 | 7,474,747 | $622.57M | – | no_change |
BVF INC/ILCIK 0001056807 | 5,502,710 | $458.32M | – | no_change |
BlackRock, Inc.CIK 0002012383 | 5,060,876 | $421.52M | +56,781 | ↑ INC |
Atlas Venture Life Science Advisors, LLCCIK 0001917529 | 4,578,008 | $381.30M | -81,866 | ↓ DEC |
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219 | 3,889,687 | $323.97M | -523,246 | ↓ DEC |
Siren, L.L.C.CIK 0002005245 | 3,186,830 | $265.43M | -100,000 | ↓ DEC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 2,880,324 | $239.90M | +2,880,324 | NEW |
VANGUARD PORTFOLIO MANAGEMENT LLCCIK 0002100121 | 2,874,056 | $239.38M | +2,874,056 | NEW |
STATE STREET CORPCIK 0000093751 | 2,389,767 | $199.04M | +179,930 | ↑ INC |
Capital Research Global InvestorsCIK 0001422848 | 1,673,275 | $139.37M | +112,484 | ↑ INC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 1,645,350 | $137.07M | +227,961 | ↑ INC |
DRIEHAUS CAPITAL MANAGEMENT LLCCIK 0000938206 | 1,043,583 | $86.92M | -25,655 | ↓ DEC |
UBS Group AGCIK 0001610520 | 1,023,852 | $85.28M | +286,820 | ↑ INC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 888,409 | $74.00M | +148,103 | ↑ INC |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLCCIK 0000861177 | 875,872 | $72.95M | -36,626 | ↓ DEC |
Holocene Advisors, LPCIK 0001700574 | 836,759 | $69.69M | +75,550 | ↑ INC |
ALLIANCEBERNSTEIN L.P.CIK 0001109448 | 888,035 | $69.10M | -64,030 | ↓ DEC |
Merck & Co., Inc.CIK 0000310158 | 772,165 | $64.31M | – | no_change |
FRONTIER CAPITAL MANAGEMENT CO LLCCIK 0000351173 | 759,848 | $63.29M | +123,891 | ↑ INC |
Commodore Capital LPCIK 0001831942 | 750,000 | $62.47M | – | no_change |
EVENTIDE ASSET MANAGEMENT, LLCCIK 0001442891 | 626,925 | $52.21M | +495 | ↑ INC |
DIMENSIONAL FUND ADVISORS LPCIK 0000354204 | 592,879 | $49.36M | -31,148 | ↓ DEC |
DEERFIELD MANAGEMENT COMPANY, L.P.CIK 0001009258 | 561,170 | $46.74M | – | no_change |
| Filer | Δ Shares | Value |
|---|---|---|
T. Rowe Price Investment Management, Inc.↑ INC | +5,368,164 | $455.18K |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +2,880,324 | $239.90M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +2,874,056 | $239.38M |
FMR LLC↑ INC | +2,771,376 | $974.49M |
VANGUARD FIDUCIARY TRUST CONEW | +427,382 | $35.60M |
UBS Group AG↑ INC | +286,820 | $85.28M |
BNP PARIBAS FINANCIAL MARKETS↑ INC | +277,073 | $23.81M |
GEODE CAPITAL MANAGEMENT, LLC↑ INC | +227,961 | $137.07M |
STATE STREET CORP↑ INC | +179,930 | $199.04M |
VOYA INVESTMENT MANAGEMENT LLC↑ INC | +169,868 | $16.56M |
| Filer | Δ Shares | Value |
|---|---|---|
WELLINGTON MANAGEMENT GROUP LLP↓ DEC | -523,246 | $323.97M |
FEDERATED HERMES, INC.↓ DEC | -227,240 | $44.70M |
Squarepoint Ops LLC↓ DEC | -146,587 | $1.07M |
BARCLAYS PLC↓ DEC | -126,260 | $1.19M |
BRAIDWELL LP↓ DEC | -116,700 | $28.12M |
Octagon Capital Advisors LP↓ DEC | -110,000 | $35.40M |
Deer Management Co. LLC↓ DEC | -104,916 | $10.49M |
Siren, L.L.C.↓ DEC | -100,000 | $265.43M |
PRICE T ROWE ASSOCIATES INC /MD/↓ DEC | -98,488 | $504.81K |
Atlas Venture Life Science Advisors, LLC↓ DEC | -81,866 | $381.30M |