| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 25, 2026 | Eisner Mark | Director | A | 47,675 | $0.0000 | $0.00 |
| Jun 9, 2026 | Lavelle Erin | Director | A | 34,843 | $0.0000 | $0.00 |
| Jun 9, 2026 | Fairmount Funds Management LLC | Director, 10% Owner | A | 34,843 | $0.0000 | $0.00 |
| Jun 9, 2026 | Klein Lawrence Otto | Director | A | 34,843 | $0.0000 | $0.00 |
| Jun 9, 2026 | DOBMEIER ERIC | Director | A | 34,843 | $0.0000 | $0.00 |
| Jun 9, 2026 | CAIN CHRISTOPHER W. | Director | A | 34,843 | $0.0000 | $0.00 |
| Feb 12, 2026 | King Andrew James | See Remarks | A | 247,500 | $0.0000 | $0.00 |
| Feb 12, 2026 | King Andrew James | See Remarks | A | 41,250 | $0.0000 | $0.00 |
| Feb 12, 2026 | Frohlich Tom | Chief Executive Officer | A | 472,500 | $0.0000 | $0.00 |
| Feb 12, 2026 | Frohlich Tom | Chief Executive Officer | A | 78,750 | $0.0000 | $0.00 |
| Feb 12, 2026 | Dahms Bradford D. | Chief Financial Officer | A | 226,875 | $0.0000 | $0.00 |
| Feb 12, 2026 | Dahms Bradford D. | Chief Financial Officer | A | 37,813 | $0.0000 | $0.00 |
| Feb 12, 2026 | Balta Elizabeth | See Remarks | A | 168,750 | $0.0000 | $0.00 |
| Feb 12, 2026 | Balta Elizabeth | See Remarks | A | 28,125 | $0.0000 | $0.00 |
| Oct 6, 2025 | Fairmount Funds Management LLC | Director, 10% Owner | A | 855,047 | $9.1399 | $7.82M |
| Oct 6, 2025 | Fairmount Funds Management LLC | Director, 10% Owner | A | 1,333,126 | $9.1400 | $12.18M |
| Jul 14, 2025 | Dahms Bradford D. | Chief Financial Officer | A | 526,000 | $0.0000 | $0.00 |
| May 16, 2025 | Frohlich Tom | Chief Executive Officer | P | 6,000 | $7.4000 | $44.40K |
| Apr 29, 2025 | DOBMEIER ERIC | Director | A | 23,017 | $0.0000 | $0.00 |
| Apr 29, 2025 | CAIN CHRISTOPHER W. | Director | A | 23,017 | $0.0000 | $0.00 |
| Apr 29, 2025 | Klein Lawrence Otto | Director | A | 23,017 | $0.0000 | $0.00 |
| Apr 29, 2025 | Lavelle Erin | Director | A | 23,017 | $0.0000 | $0.00 |
| Apr 29, 2025 | Fairmount Funds Management LLC | Director, 10% Owner | A | 23,017 | $0.0000 | $0.00 |
| Apr 28, 2025 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | J | 1,062,326 | – | – |
| Aug 1, 2024 | Dake Benjamin T | SEE REMARKS | M | 1,507 | $0.0000 | $0.00 |
| Aug 1, 2024 | Dake Benjamin T | SEE REMARKS | M | 1,507 | $1.7400 | $2.62K |
| Jul 31, 2024 | Dake Benjamin T | SEE REMARKS | M | 10,548 | $0.0000 | $0.00 |
| Jul 31, 2024 | Dake Benjamin T | SEE REMARKS | M | 906 | $0.0000 | $0.00 |
| Jul 31, 2024 | Dake Benjamin T | SEE REMARKS | M | 11,454 | $1.7400 | $19.93K |
| Jun 17, 2024 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | P | 928,110 | $1.6700 | $1.55M |
| Jun 14, 2024 | Verwijs Marinus | CHIEF TECHNICAL OFFICER | M | 10,600 | $0.0000 | $0.00 |
| Jun 14, 2024 | Verwijs Marinus | CHIEF TECHNICAL OFFICER | S | 10,600 | $25.0000 | $265.00K |
| Jun 14, 2024 | Verwijs Marinus | CHIEF TECHNICAL OFFICER | M | 10,600 | $14.5900 | $154.65K |
| Jun 14, 2024 | Eldridge George A | SEE REMARKS | M | 15,000 | $0.0000 | $0.00 |
| Jun 14, 2024 | Eldridge George A | SEE REMARKS | S | 15,000 | $25.0300 | $375.45K |
| Jun 14, 2024 | Eldridge George A | SEE REMARKS | M | 15,000 | $2.1400 | $32.10K |
| Jun 13, 2024 | Gillies Hunter | CHIEF MEDICAL OFFICER | M | 6,000 | $0.0000 | $0.00 |
| Jun 13, 2024 | Gillies Hunter | CHIEF MEDICAL OFFICER | S | 6,000 | $24.5000 | $147.00K |
| Jun 13, 2024 | Gillies Hunter | CHIEF MEDICAL OFFICER | M | 6,000 | $2.1400 | $12.84K |
| Jun 5, 2024 | Dorval Allison | Director | A | 12,500 | $0.0000 | $0.00 |
| Jun 5, 2024 | Dable Habib J | Director | A | 12,500 | $0.0000 | $0.00 |
| Jun 5, 2024 | Iwicki Mark T | Director | A | 12,500 | $0.0000 | $0.00 |
| Jun 5, 2024 | Katabi Maha | Director, 10% Owner | A | 12,500 | $0.0000 | $0.00 |
| Jun 5, 2024 | GRAYZEL DAVID S. | Director | A | 12,500 | $0.0000 | $0.00 |
| Jun 5, 2024 | Santel Donald J | Director | A | 12,500 | $0.0000 | $0.00 |
| Jun 5, 2024 | Resnick Joshua | Director | A | 12,500 | $0.0000 | $0.00 |
| Jun 5, 2024 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | A | 12,500 | $0.0000 | $0.00 |
| May 17, 2024 | Gillies Hunter | CHIEF MEDICAL OFFICER | M | 4,000 | $0.0000 | $0.00 |
| May 17, 2024 | Gillies Hunter | CHIEF MEDICAL OFFICER | S | 86 | $21.8600 | $1.88K |
| May 17, 2024 | Gillies Hunter | CHIEF MEDICAL OFFICER | S | 3,914 | $21.0658 | $82.45K |