First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
FMR LLCCIK 0000315066 | 7,085,423 | $99.55M | +190,935 | ↑ INC |
Fairmount Funds Management LLCCIK 0001802528 | 4,553,494 | $63.98M | – | no_change |
Bellevue Group AGCIK 0001674546 | 3,501,502 | $49.20M | +160,399 | ↑ INC |
Venrock Adviser, LLCCIK 0001615982 | 3,220,364 | $45.25M | – | no_change |
Avidity Partners Management LPCIK 0001791827 | 1,400,708 | $34.18M | – | no_change |
BlackRock, Inc.CIK 0002012383 | 2,313,949 | $32.51M | -556,364 | ↓ DEC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 1,796,652 | $25.24M | +1,796,652 | NEW |
BAKER BROS. ADVISORS LPCIK 0001263508 | 1,641,137 | $23.06M | – | no_change |
Remedium Capital Partners, LLCCIK 0002104501 | 1,577,750 | $22.17M | – | no_change |
Versant Venture Management, LLCCIK 0001560009 | 1,525,820 | $21.44M | – | no_change |
Samsara BioCapital, LLCCIK 0001744967 | 968,798 | $13.61M | – | no_change |
GREAT POINT PARTNERS LLCCIK 0001281446 | 964,462 | $13.55M | +158,189 | ↑ INC |
MARSHALL WACE, LLPCIK 0001318757 | 944,776 | $13.27M | +69,503 | ↑ INC |
Aberdeen Group plcCIK 0001716774 | 867,284 | $12.19M | – | no_change |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 822,520 | $11.56M | -19,288 | ↓ DEC |
Soleus Capital Management, L.P.CIK 0001802630 | 796,744 | $11.19M | – | no_change |
ACORN CAPITAL ADVISORS, LLCCIK 0002054410 | 786,760 | $11.05M | +786,760 | NEW |
STATE STREET CORPCIK 0000093751 | 655,690 | $9.21M | +12,769 | ↑ INC |
Affinity Asset Advisors, LLCCIK 0001773195 | 639,956 | $8.99M | -75,000 | ↓ DEC |
DRIEHAUS CAPITAL MANAGEMENT LLCCIK 0000938206 | 635,498 | $8.93M | -251,681 | ↓ DEC |
RTW INVESTMENTS, LPCIK 0001493215 | 573,205 | $8.05M | -876,068 | ↓ DEC |
Ikarian Capital, LLCCIK 0001778253 | 512,349 | $7.20M | +212,349 | ↑ INC |
Opaleye Management Inc.CIK 0001595855 | 427,608 | $6.01M | – | no_change |
BALYASNY ASSET MANAGEMENT L.P.CIK 0001218710 | 402,489 | $5.65M | +402,489 | NEW |
Foresite Capital Management VI LLCCIK 0002013341 | 320,000 | $4.50M | +320,000 | NEW |
| Filer | Δ Shares | Value |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +1,796,652 | $25.24M |
ACORN CAPITAL ADVISORS, LLCNEW | +786,760 | $11.05M |
BALYASNY ASSET MANAGEMENT L.P.NEW | +402,489 | $5.65M |
Foresite Capital Management VI LLCNEW | +320,000 | $4.50M |
VANGUARD FIDUCIARY TRUST CONEW | +219,497 | $3.08M |
Ikarian Capital, LLC↑ INC | +212,349 | $7.20M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +211,319 | $2.97M |
FMR LLC↑ INC | +190,935 | $99.55M |
Bellevue Group AG↑ INC | +160,399 | $49.20M |
GREAT POINT PARTNERS LLC↑ INC | +158,189 | $13.55M |
| Filer | Δ Shares | Value |
|---|---|---|
RTW INVESTMENTS, LP↓ DEC | -876,068 | $8.05M |
BlackRock, Inc.↓ DEC | -556,364 | $32.51M |
ORBIMED ADVISORS LLC↓ DEC | -346,152 | $2.60M |
ExodusPoint Capital Management, LP↓ DEC | -273,456 | $198.54K |
Point72 Asset Management, L.P.↓ DEC | -271,759 | $4.03M |
DRIEHAUS CAPITAL MANAGEMENT LLC↓ DEC | -251,681 | $8.93M |
Invesco Ltd.↓ DEC | -170,167 | $415.32K |
Nuveen, LLC↓ DEC | -78,309 | $649.62K |
Affinity Asset Advisors, LLC↓ DEC | -75,000 | $8.99M |
BARCLAYS PLC↓ DEC | -47,534 | $346.47K |