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Institutional Holders · 13F

First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.

Ownership

Institutions100.0%
Insiders18.3%
Institutions Count197
Institutions 100.0%Insiders 18.3%Float (Other) 0.0%
13F Filers (top 25)25Quarter 2026-03-31
Top-25 Reported Value$1.86BSum of shown holders' market value
Net Position Change10 adds · 10 trimsLargest movers this quarter

Top Holders by Value

25 shown
FilerSharesMarket ValueΔ SharesChange
FMR LLCCIK 0000315066
5,586,894$357.23M+136,672↑ INC
BlackRock, Inc.CIK 0002012383
2,273,831$145.39M-1,149↓ DEC
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219
1,735,376$110.96M+217,102↑ INC
STATE STREET CORPCIK 0000093751
1,698,244$108.59M+510,253↑ INC
Atlas Venture Life Science Advisors, LLCCIK 0001917529
1,513,875$96.80M–no_change
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119
1,375,430$87.94M+1,375,430NEW
Frazier Life Sciences Management, L.P.CIK 0001892134
1,354,852$86.63M+94,852↑ INC
TCG Crossover Management, LLCCIK 0001839948
1,341,862$85.80M+876,605↑ INC
JPMORGAN CHASE & COCIK 0000019617
1,371,480$83.36M-209,647↓ DEC
BVF INC/ILCIK 0001056807
1,272,312$81.35M+622,312↑ INC
ORBIMED ADVISORS LLCCIK 0001055951
1,067,550$68.26M–no_change
Siren, L.L.C.CIK 0002005245
988,401$63.20M–no_change
Woodline Partners LPCIK 0001784547
958,281$61.27M+448↑ INC
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717
744,222$47.60M+59,264↑ INC
Vestal Point Capital, LPCIK 0001974915
700,000$44.76M-35,000↓ DEC
DEERFIELD MANAGEMENT COMPANY, L.P.CIK 0001009258
657,000$42.01M+145,837↑ INC
GOLDMAN SACHS GROUP INCCIK 0000886982
639,842$40.91M-114,353↓ DEC
JENNISON ASSOCIATES LLCCIK 0000053417
610,382$39.03M+78,303↑ INC
Assenagon Asset Management S.A.CIK 0001546007
546,247$34.93M+188,411↑ INC
ARMISTICE CAPITAL, LLCCIK 0001601086
536,000$34.27M+36,609↑ INC
Bellevue Group AGCIK 0001674546
459,314$29.37M+459,314NEW
Saturn V Capital Management LPCIK 0001964437
449,926$28.77M+151,497↑ INC
Opaleye Management Inc.CIK 0001595855
421,000$26.92M+221,000↑ INC
Palo Alto Investors LPCIK 0001306923
401,719$25.69M+84,263↑ INC
EVENTIDE ASSET MANAGEMENT, LLCCIK 0001442891
395,572$25.29M+180↑ INC

Top Adds (Buyers)

FilerΔ SharesValue
VANGUARD CAPITAL MANAGEMENT LLCNEW
+1,375,430$87.94M
TCG Crossover Management, LLC↑ INC
+876,605$85.80M
BVF INC/IL↑ INC
+622,312$81.35M
STATE STREET CORP↑ INC
+510,253$108.59M
Bellevue Group AGNEW
+459,314$29.37M
Caption Management, LLC↑ INC
+292,400$19.18M
VANGUARD PORTFOLIO MANAGEMENT LLCNEW
+247,338$15.81M
Opaleye Management Inc.↑ INC
+221,000$26.92M
VANGUARD FIDUCIARY TRUST CONEW
+217,436$13.90M
WELLINGTON MANAGEMENT GROUP LLP↑ INC
+217,102$110.96M

Top Trims (Sellers)

FilerΔ SharesValue
Bain Capital Life Sciences Investors, LLC↓ DEC
-442,266$9.03M
JPMORGAN CHASE & CO↓ DEC
-209,647$83.36M
Checkpoint Capital L.P.↓ DEC
-166,331$18.33M
PRICE T ROWE ASSOCIATES INC /MD/↓ DEC
-148,655$99.07K
Octagon Capital Advisors LP↓ DEC
-145,000$17.26M
MILLENNIUM MANAGEMENT LLC↓ DEC
-125,520$5.32M
GOLDMAN SACHS GROUP INC↓ DEC
-114,353$40.91M
BOOTHBAY FUND MANAGEMENT, LLC↓ DEC
-110,781$1.37M
BARCLAYS PLC↓ DEC
-66,345$2.13M
SILVERARC CAPITAL MANAGEMENT, LLC↓ DEC
-40,443$12.53M