| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jul 2, 2026 | Stein Steven H | CMO & Head of Late-Stage Dev. | F | 2,177 | $116.8600 | $254.40K |
| Jul 2, 2026 | Meury William | Chief Executive Officer | F | 4,779 | $116.8600 | $558.47K |
| Jul 2, 2026 | Mayes Patrick A | EVP & Chief Scientific Officer | F | 350 | $116.8600 | $40.90K |
| Jul 2, 2026 | Tray Thomas | Principal Accounting Officer | F | 477 | $116.8600 | $55.74K |
| Jun 30, 2026 | HARRIGAN EDMUND | Director | A | 255 | $113.3600 | $28.91K |
| Jun 30, 2026 | Clancy Paul J | Director | A | 252 | $113.3600 | $28.57K |
| Jun 30, 2026 | BAKER BROS. ADVISORS LP | Director, 10% Owner | A | 400 | $0.0000 | $0.00 |
| Jun 30, 2026 | BAKER BROS. ADVISORS LP | Director, 10% Owner | A | 400 | $0.0000 | $0.00 |
| Jun 8, 2026 | BRAWLEY OTIS W | Director | A | 6,111 | $0.0000 | $0.00 |
| Jun 8, 2026 | BRAWLEY OTIS W | Director | A | 1,642 | $0.0000 | $0.00 |
| Jun 8, 2026 | High Katherine A | Director | A | 6,111 | $0.0000 | $0.00 |
| Jun 8, 2026 | High Katherine A | Director | A | 1,642 | $0.0000 | $0.00 |
| Jun 8, 2026 | BIENAIME JEAN JACQUES | Director | A | 6,111 | $0.0000 | $0.00 |
| Jun 8, 2026 | BIENAIME JEAN JACQUES | Director | A | 1,642 | $0.0000 | $0.00 |
| Jun 8, 2026 | FOUSE JACQUALYN A | Director | A | 6,111 | $0.0000 | $0.00 |
| Jun 8, 2026 | FOUSE JACQUALYN A | Director | A | 1,642 | $0.0000 | $0.00 |
| Jun 8, 2026 | Clancy Paul J | Director | A | 6,111 | $0.0000 | $0.00 |
| Jun 8, 2026 | Clancy Paul J | Director | A | 1,642 | $0.0000 | $0.00 |
| Jun 8, 2026 | HARRIGAN EDMUND | Director | A | 6,111 | $0.0000 | $0.00 |
| Jun 8, 2026 | HARRIGAN EDMUND | Director | A | 1,642 | $0.0000 | $0.00 |
| Jun 8, 2026 | BAKER BROS. ADVISORS LP | Director, 10% Owner | A | 6,111 | $0.0000 | $0.00 |
| Jun 8, 2026 | BAKER BROS. ADVISORS LP | Director, 10% Owner | A | 6,111 | $0.0000 | $0.00 |
| Jun 8, 2026 | BAKER BROS. ADVISORS LP | Director, 10% Owner | A | 1,642 | $0.0000 | $0.00 |
| Jun 8, 2026 | BAKER BROS. ADVISORS LP | Director, 10% Owner | A | 1,642 | $0.0000 | $0.00 |
| Jun 4, 2026 | Tray Thomas | Principal Accounting Officer | M | 2,639 | $0.0000 | $0.00 |
| Jun 4, 2026 | Tray Thomas | Principal Accounting Officer | S | 2,639 | $100.0000 | $263.90K |
| Jun 4, 2026 | Tray Thomas | Principal Accounting Officer | M | 2,639 | $83.8300 | $221.23K |
| Jun 1, 2026 | CAGNONI PABLO J | President, Global Head of R&D | F | 25,469 | $95.5900 | $2.43M |
| May 26, 2026 | BIENAIME JEAN JACQUES | Director | M | 15,000 | $0.0000 | $0.00 |
| May 26, 2026 | BIENAIME JEAN JACQUES | Director | F | 13,059 | $97.1000 | $1.27M |
| May 26, 2026 | BIENAIME JEAN JACQUES | Director | M | 15,000 | $84.5300 | $1.27M |
| May 26, 2026 | Tray Thomas | Principal Accounting Officer | S | 2,051 | $97.3500 | $199.66K |
| May 19, 2026 | Clancy Paul J | Director | M | 15,000 | $0.0000 | $0.00 |
| May 19, 2026 | Clancy Paul J | Director | S | 15,000 | $94.9300 | $1.42M |
| May 19, 2026 | Clancy Paul J | Director | M | 15,000 | $84.5300 | $1.27M |
| May 8, 2026 | BAKER BROS. ADVISORS LP | Director, 10% Owner | M | 15,000 | $0.0000 | $0.00 |
| May 8, 2026 | BAKER BROS. ADVISORS LP | Director, 10% Owner | M | 15,000 | $0.0000 | $0.00 |
| May 8, 2026 | BAKER BROS. ADVISORS LP | Director, 10% Owner | M | 15,000 | $84.5300 | $1.27M |
| May 8, 2026 | BAKER BROS. ADVISORS LP | Director, 10% Owner | M | 15,000 | $84.5300 | $1.27M |
| May 6, 2026 | CAGNONI PABLO J | President, Global Head of R&D | A | 31,517 | $0.0000 | $0.00 |
| May 6, 2026 | Stein Steven H | CMO & Head of Late-Stage Dev. | A | 44,124 | $0.0000 | $0.00 |
| May 4, 2026 | Upadhyay Suketu | EVP & Chief Financial Officer | A | 13,171 | $0.0000 | $0.00 |
| May 4, 2026 | Upadhyay Suketu | EVP & Chief Financial Officer | A | 38,429 | $0.0000 | $0.00 |
| May 4, 2026 | Upadhyay Suketu | EVP & Chief Financial Officer | A | 26,343 | $0.0000 | $0.00 |
| Apr 17, 2026 | CAGNONI PABLO J | President, Global Head of R&D | M | 12,590 | $0.0000 | $0.00 |
| Apr 17, 2026 | CAGNONI PABLO J | President, Global Head of R&D | M | 6,077 | $0.0000 | $0.00 |
| Apr 17, 2026 | CAGNONI PABLO J | President, Global Head of R&D | S | 18,667 | $96.5000 | $1.80M |
| Apr 17, 2026 | CAGNONI PABLO J | President, Global Head of R&D | M | 12,590 | $71.9300 | $905.60K |
| Apr 17, 2026 | CAGNONI PABLO J | President, Global Head of R&D | M | 6,077 | $64.2500 | $390.45K |
| Apr 15, 2026 | Stein Steven H | CMO & Head of Late-Stage Dev. | A | 39,049 | $0.0000 | $0.00 |