First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
SUVRETTA CAPITAL MANAGEMENT, LLCCIK 0001569064 | 8,296,375 | $106.94M | +468,690 | ↑ INC |
Cormorant Asset Management, LPCIK 0001583977 | 8,265,000 | $106.54M | – | no_change |
BlackRock, Inc.CIK 0002012383 | 7,177,337 | $92.52M | +389,465 | ↑ INC |
FEDERATED HERMES, INC.CIK 0001056288 | 5,669,589 | $73.08M | -347,844 | ↓ DEC |
FRANKLIN RESOURCES INCCIK 0000038777 | 5,048,598 | $65.08M | +71,683 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 3,559,569 | $45.88M | +3,559,569 | NEW |
Paradigm Biocapital Advisors LPCIK 0001855655 | 3,142,437 | $40.51M | -549,038 | ↓ DEC |
Commodore Capital LPCIK 0001831942 | 2,825,000 | $36.41M | +2,825,000 | NEW |
STATE STREET CORPCIK 0000093751 | 2,097,202 | $27.03M | +262,352 | ↑ INC |
CITADEL ADVISORS LLCCIK 0001423053 | 2,005,275 | $25.85M | +1,904,775 | ↑ INC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 1,983,665 | $25.57M | +84,298 | ↑ INC |
Aberdeen Group plcCIK 0001716774 | 1,738,378 | $22.41M | +132,394 | ↑ INC |
BALYASNY ASSET MANAGEMENT L.P.CIK 0001218710 | 1,438,737 | $18.55M | +843,345 | ↑ INC |
Parkman Healthcare Partners LLCCIK 0001777015 | 1,354,800 | $17.46M | +266,767 | ↑ INC |
EVENTIDE ASSET MANAGEMENT, LLCCIK 0001442891 | 1,245,583 | $16.06M | +1,245,583 | NEW |
MORGAN STANLEYCIK 0000895421 | 1,096,109 | $14.13M | +872,410 | ↑ INC |
Essex Woodlands Management, Inc.CIK 0001542339 | 1,084,857 | $13.98M | – | no_change |
ORBIMED ADVISORS LLCCIK 0001055951 | 1,069,147 | $13.78M | -1,399,167 | ↓ DEC |
5AM Venture Management, LLCCIK 0001799883 | 1,050,000 | $13.53M | – | no_change |
Rosalind Advisors, Inc.CIK 0001622627 | 1,036,737 | $13.36M | +346,737 | ↑ INC |
Blue Owl Capital Holdings LPCIK 0001858703 | 912,594 | $11.76M | +520,000 | ↑ INC |
HSBC HOLDINGS PLCCIK 0000873630 | 833,455 | $10.74M | +117,002 | ↑ INC |
STEMPOINT CAPITAL LPCIK 0001952142 | 810,764 | $10.45M | +456,915 | ↑ INC |
Patient Square Capital LPCIK 0001819257 | 795,000 | $10.25M | +15,000 | ↑ INC |
VANGUARD PORTFOLIO MANAGEMENT LLCCIK 0002100121 | 793,870 | $10.23M | +793,870 | NEW |
| Filer | Δ Shares | Value |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +3,559,569 | $45.88M |
Commodore Capital LPNEW | +2,825,000 | $36.41M |
CITADEL ADVISORS LLC↑ INC | +1,904,775 | $25.85M |
EVENTIDE ASSET MANAGEMENT, LLCNEW | +1,245,583 | $16.06M |
MORGAN STANLEY↑ INC | +872,410 | $14.13M |
BALYASNY ASSET MANAGEMENT L.P.↑ INC | +843,345 | $18.55M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +793,870 | $10.23M |
Sio Capital Management, LLCNEW | +721,785 | $9.30M |
Blue Owl Capital Holdings LP↑ INC | +520,000 | $11.76M |
VANGUARD FIDUCIARY TRUST CONEW | +504,472 | $6.50M |
| Filer | Δ Shares | Value |
|---|---|---|
ORBIMED ADVISORS LLC↓ DEC | -1,399,167 | $13.78M |
Point72 Asset Management, L.P.↓ DEC | -831,253 | $342.87K |
Paradigm Biocapital Advisors LP↓ DEC | -549,038 | $40.51M |
GOLDMAN SACHS GROUP INC↓ DEC | -479,951 | $9.92M |
FEDERATED HERMES, INC.↓ DEC | -347,844 | $73.08M |
Alyeska Investment Group, L.P.↓ DEC | -275,000 | $6.57M |
MARSHALL WACE, LLP↓ DEC | -227,171 | $2.09M |
Invesco Ltd.↓ DEC | -207,063 | $1.70M |
Centiva Capital, LP↓ DEC | -193,684 | $1.01M |
JANE STREET GROUP, LLC↓ DEC | -179,471 | $1.22M |