First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
Frazier Life Sciences Management, L.P.CIK 0001892134 | 24,675,188 | $399.24M | +1,945,752 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 20,151,406 | $326.05M | +4,554,076 | ↑ INC |
Venrock Adviser, LLCCIK 0001615982 | 16,382,812 | $265.07M | -1,474,271 | ↓ DEC |
RTW INVESTMENTS, LPCIK 0001493215 | 16,157,175 | $261.42M | +16,010,524 | ↑ INC |
Vivo Capital, LLCCIK 0001674712 | 12,151,480 | $196.61M | +2,878,052 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 11,249,738 | $182.02M | +11,249,738 | NEW |
Siren, L.L.C.CIK 0002005245 | 11,244,246 | $181.93M | +2,486,997 | ↑ INC |
Paradigm Biocapital Advisors LPCIK 0001855655 | 10,392,702 | $168.15M | -3,766,393 | ↓ DEC |
STATE STREET CORPCIK 0000093751 | 9,300,084 | $150.48M | +3,125,442 | ↑ INC |
ARCH Venture Management, LLCCIK 0001274403 | 7,091,557 | $114.74M | -3,963,997 | ↓ DEC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 5,996,149 | $97.04M | +1,069,814 | ↑ INC |
Cormorant Asset Management, LPCIK 0001583977 | 5,800,000 | $93.84M | -5,013,246 | ↓ DEC |
Affinity Asset Advisors, LLCCIK 0001773195 | 5,350,000 | $86.56M | +1,450,000 | ↑ INC |
BALYASNY ASSET MANAGEMENT L.P.CIK 0001218710 | 5,143,985 | $83.23M | +5,045,912 | ↑ INC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 4,875,186 | $78.88M | +1,543,768 | ↑ INC |
5AM Venture Management, LLCCIK 0001799883 | 3,485,971 | $56.40M | -1,919,433 | ↓ DEC |
SUVRETTA CAPITAL MANAGEMENT, LLCCIK 0001569064 | 3,434,967 | $55.58M | -11,067,037 | ↓ DEC |
Commodore Capital LPCIK 0001831942 | 3,175,000 | $51.37M | +3,175,000 | NEW |
BANK OF AMERICA CORP /DE/CIK 0000070858 | 3,055,897 | $49.44M | +1,444,047 | ↑ INC |
a16z Capital Management, L.L.C.CIK 0001540358 | 2,862,500 | $46.32M | – | no_change |
Woodline Partners LPCIK 0001784547 | 2,831,538 | $45.81M | +900,896 | ↑ INC |
CHARLES SCHWAB INVESTMENT MANAGEMENT INCCIK 0000884546 | 1,898,224 | $30.71M | +224,820 | ↑ INC |
SILVERARC CAPITAL MANAGEMENT, LLCCIK 0001816307 | 1,851,812 | $29.96M | +534,228 | ↑ INC |
UBS Group AGCIK 0001610520 | 1,848,580 | $29.91M | +1,678,049 | ↑ INC |
DIMENSIONAL FUND ADVISORS LPCIK 0000354204 | 1,786,389 | $28.87M | +10,704 | ↑ INC |
| Filer | Δ Shares | Value |
|---|---|---|
T. Rowe Price Investment Management, Inc.↑ INC | +16,472,821 | $343.98K |
RTW INVESTMENTS, LP↑ INC | +16,010,524 | $261.42M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +11,249,738 | $182.02M |
BALYASNY ASSET MANAGEMENT L.P.↑ INC | +5,045,912 | $83.23M |
BlackRock, Inc.↑ INC | +4,554,076 | $326.05M |
Commodore Capital LPNEW | +3,175,000 | $51.37M |
STATE STREET CORP↑ INC | +3,125,442 | $150.48M |
Vivo Capital, LLC↑ INC | +2,878,052 | $196.61M |
Siren, L.L.C.↑ INC | +2,486,997 | $181.93M |
ALLIANCEBERNSTEIN L.P.↑ INC | +2,436,110 | $9.84M |
| Filer | Δ Shares | Value |
|---|---|---|
SUVRETTA CAPITAL MANAGEMENT, LLC↓ DEC | -11,067,037 | $55.58M |
Cormorant Asset Management, LP↓ DEC | -5,013,246 | $93.84M |
ARCH Venture Management, LLC↓ DEC | -3,963,997 | $114.74M |
Paradigm Biocapital Advisors LP↓ DEC | -3,766,393 | $168.15M |
Spruce Street Capital LP↓ DEC | -3,467,089 | $6.84M |
5AM Venture Management, LLC↓ DEC | -1,919,433 | $56.40M |
MILLENNIUM MANAGEMENT LLC↓ DEC | -1,661,955 | $9.32M |
Venrock Adviser, LLC↓ DEC | -1,474,271 | $265.07M |
Caption Management, LLC↓ DEC | -1,374,900 | $9.91M |
Sio Capital Management, LLC↓ DEC | -1,364,748 | $80.90K |