| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jul 6, 2026 | Kunkel Lori Anne | Director | S | 5,889 | $50.8442 | $299.42K |
| Jul 6, 2026 | Kunkel Lori Anne | Director | S | 4,111 | $49.9834 | $205.48K |
| Jun 22, 2026 | ORBIMED ADVISORS LLC | 10% Owner | S | 46,776 | $45.0000 | $2.10M |
| Jun 22, 2026 | ORBIMED ADVISORS LLC | 10% Owner | S | 787,024 | $45.3800 | $35.72M |
| Jun 22, 2026 | ORBIMED ADVISORS LLC | 10% Owner | S | 1,477 | $45.0000 | $66.47K |
| Jun 22, 2026 | ORBIMED ADVISORS LLC | 10% Owner | S | 24,846 | $45.3800 | $1.13M |
| Jun 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 5,000 | $0.0000 | $0.00 |
| Jun 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 1,133 | $44.7430 | $50.69K |
| Jun 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 2,599 | $43.8701 | $114.02K |
| Jun 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 1,268 | $42.8270 | $54.30K |
| Jun 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 5,000 | $2.4800 | $12.40K |
| Jun 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | M | 6,018 | $0.0000 | $0.00 |
| Jun 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | S | 1,238 | $44.7475 | $55.40K |
| Jun 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | S | 3,401 | $43.8634 | $149.18K |
| Jun 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | S | 1,379 | $42.7850 | $59.00K |
| Jun 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | M | 6,018 | $2.4800 | $14.92K |
| Jun 15, 2026 | ORBIMED ADVISORS LLC | 10% Owner | S | 272,322 | $45.0200 | $12.26M |
| Jun 15, 2026 | ORBIMED ADVISORS LLC | 10% Owner | S | 9,086 | $45.0200 | $409.05K |
| Jun 5, 2026 | Kunkel Lori Anne | Director | S | 354 | $35.8187 | $12.68K |
| Jun 5, 2026 | Kunkel Lori Anne | Director | S | 1,867 | $35.3573 | $66.01K |
| Jun 5, 2026 | Kunkel Lori Anne | Director | S | 7,779 | $34.2794 | $266.66K |
| May 18, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 5,000 | $0.0000 | $0.00 |
| May 18, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 223 | $41.2052 | $9.19K |
| May 18, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 1,302 | $40.2473 | $52.40K |
| May 18, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 3,475 | $39.5340 | $137.38K |
| May 18, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 5,000 | $2.4800 | $12.40K |
| Apr 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 5,000 | $0.0000 | $0.00 |
| Apr 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 2,441 | $48.0555 | $117.30K |
| Apr 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 2,419 | $47.3896 | $114.64K |
| Apr 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 140 | $45.8107 | $6.41K |
| Apr 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 5,000 | $2.4800 | $12.40K |
| Mar 25, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 40,000 | $0.0000 | $0.00 |
| Mar 25, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 40,000 | $35.1006 | $1.40M |
| Mar 25, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 40,000 | $2.4800 | $99.20K |
| Mar 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 5,000 | $0.0000 | $0.00 |
| Mar 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 5,000 | $27.7600 | $138.80K |
| Mar 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 5,000 | $2.4800 | $12.40K |
| Mar 10, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 10,129 | $0.0000 | $0.00 |
| Mar 10, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 10,129 | $30.1932 | $305.83K |
| Mar 10, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 10,129 | $2.4800 | $25.12K |
| Mar 9, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 29,871 | $0.0000 | $0.00 |
| Mar 9, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 29,871 | $30.0228 | $896.81K |
| Mar 9, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 29,871 | $2.4800 | $74.08K |
| Mar 6, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | S | 10,000 | $29.5839 | $295.84K |
| Feb 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 45,000 | $0.0000 | $0.00 |
| Feb 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 45,000 | $26.1747 | $1.18M |
| Feb 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 45,000 | $2.4800 | $111.60K |
| Feb 17, 2026 | Heyman Richard A. | Director | S | 1,230 | $26.1759 | $32.20K |
| Feb 12, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | A | 150,000 | $0.0000 | $0.00 |
| Feb 12, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | A | 25,000 | $0.0000 | $0.00 |