| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 3, 2026 | BAKER BROS. ADVISORS LP | Director | A | 19,226 | $0.0000 | $0.00 |
| Jun 3, 2026 | BAKER BROS. ADVISORS LP | Director | A | 19,226 | $0.0000 | $0.00 |
| Jun 3, 2026 | BAKER BROS. ADVISORS LP | Director | A | 6,408 | $0.0000 | $0.00 |
| Jun 3, 2026 | BAKER BROS. ADVISORS LP | Director | A | 6,408 | $0.0000 | $0.00 |
| Jun 3, 2026 | Cook Jennifer E. | Director | A | 19,226 | $0.0000 | $0.00 |
| Jun 3, 2026 | Cook Jennifer E. | Director | A | 6,408 | $0.0000 | $0.00 |
| Jun 3, 2026 | Van Hauwermeiren Timothy | Director | A | 19,226 | $0.0000 | $0.00 |
| Jun 3, 2026 | Van Hauwermeiren Timothy | Director | A | 6,408 | $0.0000 | $0.00 |
| Jun 3, 2026 | Thornberry Nancy | Director | A | 19,226 | $0.0000 | $0.00 |
| Jun 3, 2026 | Thornberry Nancy | Director | A | 6,408 | $0.0000 | $0.00 |
| Jun 3, 2026 | Schenkein David P | Director | A | 19,226 | $0.0000 | $0.00 |
| Jun 3, 2026 | Schenkein David P | Director | A | 6,408 | $0.0000 | $0.00 |
| Jun 3, 2026 | Krognes Steve E. | Director | A | 19,226 | $0.0000 | $0.00 |
| Jun 3, 2026 | Krognes Steve E. | Director | A | 6,408 | $0.0000 | $0.00 |
| Jun 3, 2026 | Klein Peter S | Director | A | 19,226 | $0.0000 | $0.00 |
| Jun 3, 2026 | Klein Peter S | Director | A | 6,408 | $0.0000 | $0.00 |
| Jun 3, 2026 | FLATLEY JAY T | Director | A | 19,226 | $0.0000 | $0.00 |
| Jun 3, 2026 | FLATLEY JAY T | Director | A | 6,408 | $0.0000 | $0.00 |
| Jan 6, 2026 | Schuth Alexander O. | COFO and Secretary | S | 17,218 | $16.5000 | $284.10K |
| Jan 6, 2026 | Watts Ryan J. | President and CEO | S | 35,198 | $16.5000 | $580.77K |
| Jan 3, 2026 | Watts Ryan J. | President and CEO | A | 236,880 | $0.0000 | $0.00 |
| Jan 3, 2026 | Watts Ryan J. | President and CEO | A | 78,960 | $0.0000 | $0.00 |
| Jan 3, 2026 | Schuth Alexander O. | COFO and Secretary | A | 173,100 | $0.0000 | $0.00 |
| Jan 3, 2026 | Schuth Alexander O. | COFO and Secretary | A | 57,700 | $0.0000 | $0.00 |
| Dec 11, 2025 | BAKER BROS. ADVISORS LP | Director | P | 2,095,191 | $17.4900 | $36.64M |
| Dec 11, 2025 | BAKER BROS. ADVISORS LP | Director | P | 190,523 | $17.4900 | $3.33M |
| Nov 4, 2025 | Van Hauwermeiren Timothy | Director | A | 31,897 | $0.0000 | $0.00 |
| Nov 4, 2025 | Van Hauwermeiren Timothy | Director | A | 10,632 | $0.0000 | $0.00 |
| Sep 3, 2025 | Watts Ryan J. | President and CEO | G | 50,000 | $0.0000 | $0.00 |
| Aug 13, 2025 | Ho Carole | Chief Medical Officer | S | 806 | $14.6400 | $11.80K |
| Aug 12, 2025 | Ho Carole | Chief Medical Officer | S | 2,937 | $13.5800 | $39.88K |
| Aug 12, 2025 | Schuth Alexander O. | COFO and Secretary | S | 2,937 | $13.5800 | $39.88K |
| Aug 5, 2025 | Ho Carole | Chief Medical Officer | M | 44,655 | $0.0000 | $0.00 |
| Aug 5, 2025 | Ho Carole | Chief Medical Officer | M | 44,655 | $0.6800 | $30.36K |
| Jul 9, 2025 | Watts Ryan J. | President and CEO | M | 40,000 | $0.0000 | $0.00 |
| Jul 9, 2025 | Watts Ryan J. | President and CEO | M | 455,282 | $0.0000 | $0.00 |
| Jul 9, 2025 | Watts Ryan J. | President and CEO | S | 495,282 | $15.0000 | $7.43M |
| Jul 9, 2025 | Watts Ryan J. | President and CEO | M | 40,000 | $5.2800 | $211.20K |
| Jul 9, 2025 | Watts Ryan J. | President and CEO | M | 455,282 | $0.6800 | $309.59K |
| Jun 3, 2025 | Tessier-Lavigne Marc | Director | A | 18,111 | $0.0000 | $0.00 |
| Jun 3, 2025 | Tessier-Lavigne Marc | Director | A | 6,037 | $0.0000 | $0.00 |
| Jun 3, 2025 | Thornberry Nancy | Director | A | 18,111 | $0.0000 | $0.00 |
| Jun 3, 2025 | Thornberry Nancy | Director | A | 6,037 | $0.0000 | $0.00 |
| Jun 3, 2025 | Schenkein David P | Director | A | 18,111 | $0.0000 | $0.00 |
| Jun 3, 2025 | Schenkein David P | Director | A | 6,037 | $0.0000 | $0.00 |
| Jun 3, 2025 | Krognes Steve E. | Director | A | 18,111 | $0.0000 | $0.00 |
| Jun 3, 2025 | Krognes Steve E. | Director | A | 6,037 | $0.0000 | $0.00 |
| Jun 3, 2025 | Klein Peter S | Director | A | 18,111 | $0.0000 | $0.00 |
| Jun 3, 2025 | Klein Peter S | Director | A | 6,037 | $0.0000 | $0.00 |
| Jun 3, 2025 | FLATLEY JAY T | Director | A | 18,111 | $0.0000 | $0.00 |