| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 11, 2026 | van den Broek Richard | Director | A | 15,000 | $0.0000 | $0.00 |
| Jun 11, 2026 | Thompson Peter A. | Director, 10% Owner | A | 15,000 | $0.0000 | $0.00 |
| Jun 11, 2026 | Grais Linda | Director | A | 15,000 | $0.0000 | $0.00 |
| Jun 11, 2026 | CLARK IAN T | Director | A | 15,000 | $0.0000 | $0.00 |
| Jun 11, 2026 | Moore David Scott | Director | A | 15,000 | $0.0000 | $0.00 |
| Jun 11, 2026 | Moore David Scott | Director | P | 21,700 | $11.5316 | $250.24K |
| May 18, 2026 | MILLER RICHARD A MD | President and CEO | P | 1,932 | $12.0100 | $23.20K |
| May 18, 2026 | MILLER RICHARD A MD | President and CEO | P | 5,000 | $12.0500 | $60.25K |
| Apr 23, 2026 | Chan Andrew C. | Director | A | 30,000 | $0.0000 | $0.00 |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $0.0000 | $0.00 |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $0.0000 | $0.00 |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $0.0000 | $0.00 |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $0.0000 | $0.00 |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $0.0000 | $0.00 |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $0.0000 | $0.00 |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $0.0000 | $0.00 |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $0.0000 | $0.00 |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $0.0000 | $0.00 |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $0.0000 | $0.00 |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $0.0000 | $0.00 |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $0.0000 | $0.00 |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 30,000 | $0.0000 | $0.00 |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $2.1200 | $31.80K |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $1.6400 | $24.60K |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $2.4900 | $37.35K |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $0.9650 | $14.47K |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $0.9899 | $14.85K |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $2.6000 | $39.00K |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $2.7400 | $41.10K |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $3.2700 | $49.05K |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $2.0000 | $30.00K |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $3.6100 | $54.15K |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $12.5000 | $187.50K |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 15,000 | $9.7000 | $145.50K |
| Jan 28, 2026 | Thompson Peter A. | Director, 10% Owner | M | 30,000 | $15.0000 | $450.00K |
| Dec 4, 2025 | LEA LEIV | Chief Financial Officer | A | 400,000 | $0.0000 | $0.00 |
| Dec 4, 2025 | Arcara Jeffrey | Chief Business Officer | A | 100,000 | $0.0000 | $0.00 |
| Dec 4, 2025 | MILLER RICHARD A MD | President and CEO | A | 1,000,000 | $0.0000 | $0.00 |
| Dec 4, 2025 | Jones William Benton | See Remarks | A | 400,000 | $0.0000 | $0.00 |
| Oct 2, 2025 | Moore David Scott | Director | A | 30,000 | $0.0000 | $0.00 |
| Jun 27, 2025 | ORBIMED ADVISORS LLC | Director, 10% Owner | X | 1,397,684 | $0.0000 | $0.00 |
| Jun 27, 2025 | ORBIMED ADVISORS LLC | Director, 10% Owner | S | 1,176,332 | $4.1586 | $4.89M |
| Jun 27, 2025 | ORBIMED ADVISORS LLC | Director, 10% Owner | X | 1,397,684 | $3.5000 | $4.89M |
| Jun 27, 2025 | Thompson Peter A. | Director, 10% Owner | X | 1,397,684 | $0.0000 | $0.00 |
| Jun 27, 2025 | Thompson Peter A. | Director, 10% Owner | S | 1,176,332 | $4.1586 | $4.89M |
| Jun 27, 2025 | Thompson Peter A. | Director, 10% Owner | X | 1,397,684 | $3.5000 | $4.89M |
| Jun 12, 2025 | Morrison Scott W | Director | A | 15,000 | $0.0000 | $0.00 |
| Jun 12, 2025 | Thompson Peter A. | Director, 10% Owner | A | 15,000 | $0.0000 | $0.00 |
| Jun 12, 2025 | CLARK IAN T | Director | A | 15,000 | $0.0000 | $0.00 |
| Jun 12, 2025 | Grais Linda | Director | A | 15,000 | $0.0000 | $0.00 |