First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
RTW INVESTMENTS, LPCIK 0001493215 | 6,984,808 | $472.73M | +4,972,681 | ↑ INC |
Decheng Capital LLCCIK 0002010850 | 6,371,669 | $431.23M | – | no_change |
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219 | 5,371,232 | $363.52M | -628,558 | ↓ DEC |
BlackRock, Inc.CIK 0002012383 | 5,064,180 | $342.74M | +220,938 | ↑ INC |
FMR LLCCIK 0000315066 | 3,764,844 | $254.80M | -533,329 | ↓ DEC |
TCG Crossover Management, LLCCIK 0001839948 | 3,670,206 | $248.40M | – | no_change |
VANGUARD PORTFOLIO MANAGEMENT LLCCIK 0002100121 | 3,095,098 | $209.48M | +3,095,098 | NEW |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 3,033,625 | $205.32M | +3,033,625 | NEW |
Caption Management, LLCCIK 0001706766 | 2,758,880 | $186.72M | +1,449,634 | ↑ INC |
STATE STREET CORPCIK 0000093751 | 2,647,054 | $179.15M | -349,641 | ↓ DEC |
Foresite Capital Management VI LLCCIK 0002013341 | 2,221,474 | $150.35M | – | no_change |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 1,596,864 | $108.10M | +85,331 | ↑ INC |
FRANKLIN RESOURCES INCCIK 0000038777 | 1,507,005 | $101.99M | -54,569 | ↓ DEC |
BANK OF AMERICA CORP /DE/CIK 0000070858 | 1,449,364 | $98.09M | +259,311 | ↑ INC |
DV Trading LLCCIK 0001721757 | 1,439,393 | $97.42M | – | no_change |
UBS Group AGCIK 0001610520 | 1,311,978 | $88.79M | -611,768 | ↓ DEC |
Avidity Partners Management LPCIK 0001791827 | 1,288,948 | $87.24M | -183,751 | ↓ DEC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 1,159,239 | $78.46M | -165,364 | ↓ DEC |
ACORN CAPITAL ADVISORS, LLCCIK 0002054410 | 1,130,501 | $76.58M | -1,000 | ↓ DEC |
EcoR1 Capital, LLCCIK 0001587114 | 1,102,000 | $74.58M | +37,200 | ↑ INC |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLCCIK 0000861177 | 1,064,966 | $72.08M | -25,928 | ↓ DEC |
Foresite Capital Management V, LLCCIK 0001792206 | 1,004,050 | $67.95M | – | no_change |
DRIEHAUS CAPITAL MANAGEMENT LLCCIK 0000938206 | 999,623 | $67.65M | +801,686 | ↑ INC |
BRAIDWELL LPCIK 0001920938 | 984,783 | $66.65M | -885,788 | ↓ DEC |
ORBIMED ADVISORS LLCCIK 0001055951 | 948,267 | $64.18M | -568,283 | ↓ DEC |
| Filer | Δ Shares | Value |
|---|---|---|
T. Rowe Price Investment Management, Inc.↑ INC | +6,678,539 | $454.84K |
RTW INVESTMENTS, LP↑ INC | +4,972,681 | $472.73M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +3,095,098 | $209.48M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +3,033,625 | $205.32M |
Caption Management, LLC↑ INC | +1,449,634 | $186.72M |
Caligan Partners LPNEW | +900,000 | $60.91M |
DRIEHAUS CAPITAL MANAGEMENT LLC↑ INC | +801,686 | $67.65M |
FARALLON CAPITAL MANAGEMENT, L.L.C.↑ INC | +666,000 | $45.62M |
VANGUARD FIDUCIARY TRUST CONEW | +470,257 | $31.83M |
Fisher Asset Management, LLCNEW | +465,033 | $31.47M |
| Filer | Δ Shares | Value |
|---|---|---|
Pictet Asset Management Holding SA↓ DEC | -951,522 | $26.94M |
BRAIDWELL LP↓ DEC | -885,788 | $66.65M |
WELLINGTON MANAGEMENT GROUP LLP↓ DEC | -628,558 | $363.52M |
UBS Group AG↓ DEC | -611,768 | $88.79M |
ORBIMED ADVISORS LLC↓ DEC | -568,283 | $64.18M |
FMR LLC↓ DEC | -533,329 | $254.80M |
CITADEL ADVISORS LLC↓ DEC | -510,071 | $18.13M |
STATE STREET CORP↓ DEC | -349,641 | $179.15M |
ALLIANCEBERNSTEIN L.P.↓ DEC | -323,338 | $53.56M |
Opaleye Management Inc.↓ DEC | -315,200 | $6.42M |