| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 30, 2026 | Simon Amy | Chief Medical Officer | S | 373 | $34.7300 | $12.95K |
| Jun 30, 2026 | Evans John M. | CEO | M | 25,000 | $0.0000 | $0.00 |
| Jun 30, 2026 | Evans John M. | CEO | S | 1,900 | $34.8437 | $66.20K |
| Jun 30, 2026 | Evans John M. | CEO | S | 23,100 | $34.2633 | $791.48K |
| Jun 30, 2026 | Evans John M. | CEO | M | 25,000 | $1.0300 | $25.75K |
| Jun 29, 2026 | Evans John M. | CEO | M | 6,337 | $0.0000 | $0.00 |
| Jun 29, 2026 | Evans John M. | CEO | M | 18,663 | $0.0000 | $0.00 |
| Jun 29, 2026 | Evans John M. | CEO | S | 11,579 | $35.9119 | $415.82K |
| Jun 29, 2026 | Evans John M. | CEO | S | 13,421 | $35.1336 | $471.53K |
| Jun 29, 2026 | Evans John M. | CEO | M | 6,337 | $1.0300 | $6.53K |
| Jun 29, 2026 | Evans John M. | CEO | M | 18,663 | $0.6700 | $12.50K |
| Jun 26, 2026 | FMR LLC | 10% Owner, Other | S | 251,488 | $35.2600 | $8.87M |
| Jun 25, 2026 | FMR LLC | 10% Owner, Other | S | 33,372 | $35.1200 | $1.17M |
| Jun 17, 2026 | Ciaramella Giuseppe | President | M | 29,000 | $0.0000 | $0.00 |
| Jun 17, 2026 | Ciaramella Giuseppe | President | M | 6,505 | $0.0000 | $0.00 |
| Jun 17, 2026 | Ciaramella Giuseppe | President | M | 29,000 | $1.0300 | $29.87K |
| Jun 17, 2026 | Ciaramella Giuseppe | President | M | 6,505 | $0.6700 | $4.36K |
| Jun 3, 2026 | COOPER GRAHAM K | Director | A | 19,676 | $0.0000 | $0.00 |
| Jun 3, 2026 | Guindo Chirfi | Director | A | 19,676 | $0.0000 | $0.00 |
| Jun 3, 2026 | MARAGANORE JOHN | Director | A | 19,676 | $0.0000 | $0.00 |
| Jun 3, 2026 | Fishman Mark | Director | A | 19,676 | $0.0000 | $0.00 |
| Jun 3, 2026 | Walsh Kathleen E | Director | A | 19,676 | $0.0000 | $0.00 |
| Jun 3, 2026 | Shaw Christi | Director | A | 19,676 | $0.0000 | $0.00 |
| Apr 1, 2026 | Ciaramella Giuseppe | President | S | 11,810 | $24.5800 | $290.29K |
| Apr 1, 2026 | Cavanagh Bethany J | SVP, Finance and Treasurer | S | 3,242 | $24.5800 | $79.69K |
| Apr 1, 2026 | Bellon Christine | Chief Legal Officer | S | 5,956 | $24.5800 | $146.40K |
| Apr 1, 2026 | Simon Amy | Chief Medical Officer | S | 6,700 | $24.5800 | $164.69K |
| Apr 1, 2026 | Evans John M. | CEO | S | 30,078 | $24.5800 | $739.32K |
| Mar 31, 2026 | Evans John M. | CEO | M | 25,000 | $0.0000 | $0.00 |
| Mar 31, 2026 | Evans John M. | CEO | A | 90,000 | $0.0000 | $0.00 |
| Mar 31, 2026 | Evans John M. | CEO | S | 25,000 | $22.7634 | $569.09K |
| Mar 31, 2026 | Evans John M. | CEO | M | 25,000 | $0.6700 | $16.75K |
| Mar 31, 2026 | Ciaramella Giuseppe | President | A | 40,000 | $0.0000 | $0.00 |
| Mar 31, 2026 | Emany Sravan Kumar | Chief Financial Officer | A | 31,750 | $0.0000 | $0.00 |
| Mar 31, 2026 | Simon Amy | Chief Medical Officer | A | 31,750 | $0.0000 | $0.00 |
| Mar 31, 2026 | Cavanagh Bethany J | SVP, Finance and Treasurer | A | 20,000 | $0.0000 | $0.00 |
| Mar 31, 2026 | Bellon Christine | Chief Legal Officer | A | 20,000 | $0.0000 | $0.00 |
| Mar 30, 2026 | Evans John M. | CEO | M | 25,000 | $0.0000 | $0.00 |
| Mar 30, 2026 | Evans John M. | CEO | S | 25,000 | $22.3692 | $559.23K |
| Mar 30, 2026 | Evans John M. | CEO | M | 25,000 | $0.6700 | $16.75K |
| Feb 24, 2026 | Ciaramella Giuseppe | President | M | 35,000 | $0.0000 | $0.00 |
| Feb 24, 2026 | Ciaramella Giuseppe | President | S | 35,000 | $32.0012 | $1.12M |
| Feb 24, 2026 | Ciaramella Giuseppe | President | M | 35,000 | $17.0000 | $595.00K |
| Jan 31, 2026 | Evans John M. | CEO | A | 180,000 | $0.0000 | $0.00 |
| Jan 31, 2026 | Simon Amy | Chief Medical Officer | A | 88,500 | $0.0000 | $0.00 |
| Jan 31, 2026 | Bellon Christine | Chief Legal Officer | A | 40,000 | $0.0000 | $0.00 |
| Jan 31, 2026 | Emany Sravan Kumar | Chief Financial Officer | A | 63,500 | $0.0000 | $0.00 |
| Jan 31, 2026 | Ciaramella Giuseppe | President | A | 80,000 | $0.0000 | $0.00 |
| Jan 31, 2026 | Cavanagh Bethany J | SVP, Finance and Treasurer | A | 40,000 | $0.0000 | $0.00 |
| Jan 30, 2026 | Evans John M. | CEO | M | 25,000 | $0.0000 | $0.00 |