First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
FMR LLCCIK 0000315066 | 2,879,481 | $42.99M | +2,659,181 | ↑ INC |
Caligan Partners LPCIK 0001727492 | 1,635,023 | $24.41M | +753,490 | ↑ INC |
BVF INC/ILCIK 0001056807 | 1,632,845 | $24.38M | +277,588 | ↑ INC |
Avoro Capital Advisors LLCCIK 0001633313 | 1,410,000 | $21.05M | +1,410,000 | NEW |
Affinity Asset Advisors, LLCCIK 0001773195 | 1,340,840 | $20.02M | +289,786 | ↑ INC |
UBS Group AGCIK 0001610520 | 1,141,980 | $17.05M | +664,164 | ↑ INC |
Caption Management, LLCCIK 0001706766 | 1,086,700 | $16.22M | +784,059 | ↑ INC |
Point72 Asset Management, L.P.CIK 0001603466 | 916,142 | $13.68M | +288,640 | ↑ INC |
FARALLON CAPITAL MANAGEMENT, L.L.C.CIK 0000909661 | 916,000 | $13.68M | +916,000 | NEW |
RTW INVESTMENTS, LPCIK 0001493215 | 856,962 | $12.79M | +856,962 | NEW |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 835,484 | $12.47M | +175,505 | ↑ INC |
TCG Crossover Management, LLCCIK 0001839948 | 738,383 | $11.02M | +255,383 | ↑ INC |
BALYASNY ASSET MANAGEMENT L.P.CIK 0001218710 | 731,586 | $10.92M | +292,274 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 719,694 | $10.75M | +719,694 | NEW |
BANK OF AMERICA CORP /DE/CIK 0000070858 | 643,000 | $9.60M | +21,650 | ↑ INC |
SUSQUEHANNA INTERNATIONAL GROUP, LLPCIK 0001446194 | 637,200 | $9.51M | +341,206 | ↑ INC |
Ikarian Capital, LLCCIK 0001778253 | 560,000 | $8.36M | +470,794 | ↑ INC |
BOOTHBAY FUND MANAGEMENT, LLCCIK 0001549230 | 485,758 | $7.25M | +266,531 | ↑ INC |
Commodore Capital LPCIK 0001831942 | 483,000 | $7.21M | – | no_change |
ORBIMED ADVISORS LLCCIK 0001055951 | 475,165 | $7.09M | -712,135 | ↓ DEC |
JENNISON ASSOCIATES LLCCIK 0000053417 | 470,775 | $7.03M | -4,850 | ↓ DEC |
Soleus Capital Management, L.P.CIK 0001802630 | 441,978 | $6.60M | – | no_change |
BNP PARIBAS FINANCIAL MARKETSCIK 0001166588 | 422,781 | $6.31M | +225,034 | ↑ INC |
KENNEDY CAPITAL MANAGEMENT LLCCIK 0000884589 | 387,982 | $5.79M | +387,982 | NEW |
DV Trading LLCCIK 0001721757 | 360,064 | $5.38M | +360,064 | NEW |
| Filer | Δ Shares | Value |
|---|---|---|
FMR LLC↑ INC | +2,659,181 | $42.99M |
T. Rowe Price Investment Management, Inc.NEW | +2,162,684 | $32.29K |
Avoro Capital Advisors LLCNEW | +1,410,000 | $21.05M |
FARALLON CAPITAL MANAGEMENT, L.L.C.NEW | +916,000 | $13.68M |
RTW INVESTMENTS, LPNEW | +856,962 | $12.79M |
Caption Management, LLC↑ INC | +784,059 | $16.22M |
Caligan Partners LP↑ INC | +753,490 | $24.41M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +719,694 | $10.75M |
UBS Group AG↑ INC | +664,164 | $17.05M |
Ikarian Capital, LLC↑ INC | +470,794 | $8.36M |
| Filer | Δ Shares | Value |
|---|---|---|
ORBIMED ADVISORS LLC↓ DEC | -712,135 | $7.09M |
MARSHALL WACE, LLP↓ DEC | -378,414 | $1.93M |
CITADEL ADVISORS LLC↓ DEC | -158,956 | $3.89M |
MORGAN STANLEY↓ DEC | -103,515 | $2.41M |
BARCLAYS PLC↓ DEC | -91,172 | $218.60K |
TWO SIGMA INVESTMENTS, LP↓ DEC | -83,812 | $961.87K |
Velan Capital Investment Management LP↓ DEC | -78,520 | $2.76M |
AMERIPRISE FINANCIAL INC↓ DEC | -45,825 | $2.57M |
HighVista Strategies LLC↓ DEC | -37,009 | $875.23K |
DLD Asset Management, LP↓ DEC | -26,900 | $742.50K |