| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 1, 2026 | Cravatt Benjamin | Director | A | 4,393 | $0.0000 | $0.00 |
| Jun 1, 2026 | PYOTT DAVID E I | Director | M | 3,830 | $0.0000 | $0.00 |
| Jun 1, 2026 | PYOTT DAVID E I | Director | S | 17 | $302.6500 | $5.14K |
| Jun 1, 2026 | PYOTT DAVID E I | Director | S | 495 | $300.7200 | $148.86K |
| Jun 1, 2026 | PYOTT DAVID E I | Director | S | 1,222 | $299.8700 | $366.44K |
| Jun 1, 2026 | PYOTT DAVID E I | Director | S | 1,175 | $298.9100 | $351.22K |
| Jun 1, 2026 | PYOTT DAVID E I | Director | S | 921 | $297.7100 | $274.19K |
| Jun 1, 2026 | PYOTT DAVID E I | Director | M | 3,830 | $0.0000 | $0.00 |
| May 20, 2026 | Arbuckle Stuart A | Director | A | 1,441 | $0.0000 | $0.00 |
| May 20, 2026 | Arbuckle Stuart A | Director | A | 671 | $0.0000 | $0.00 |
| May 20, 2026 | Ausiello Dennis A | Director | A | 1,441 | $0.0000 | $0.00 |
| May 20, 2026 | Ausiello Dennis A | Director | A | 671 | $0.0000 | $0.00 |
| May 20, 2026 | BRANDICOURT OLIVIER | Director | A | 1,441 | $0.0000 | $0.00 |
| May 20, 2026 | BRANDICOURT OLIVIER | Director | A | 671 | $0.0000 | $0.00 |
| May 20, 2026 | HAMBURG MARGARET A | Director | A | 1,441 | $0.0000 | $0.00 |
| May 20, 2026 | HAMBURG MARGARET A | Director | A | 671 | $0.0000 | $0.00 |
| May 20, 2026 | KELLOGG PETER N | Director | A | 1,441 | $0.0000 | $0.00 |
| May 20, 2026 | KELLOGG PETER N | Director | A | 671 | $0.0000 | $0.00 |
| May 20, 2026 | PYOTT DAVID E I | Director | A | 1,441 | $0.0000 | $0.00 |
| May 20, 2026 | PYOTT DAVID E I | Director | A | 671 | $0.0000 | $0.00 |
| May 20, 2026 | Reitan Colleen F | Director | A | 1,441 | $0.0000 | $0.00 |
| May 20, 2026 | Reitan Colleen F | Director | A | 671 | $0.0000 | $0.00 |
| May 20, 2026 | SCHULMAN AMY W | Director | A | 1,802 | $0.0000 | $0.00 |
| May 20, 2026 | SCHULMAN AMY W | Director | A | 838 | $0.0000 | $0.00 |
| May 20, 2026 | Sigal Charles Elliott | Director | A | 1,441 | $0.0000 | $0.00 |
| May 20, 2026 | Sigal Charles Elliott | Director | A | 671 | $0.0000 | $0.00 |
| May 13, 2026 | SCHULMAN AMY W | Director | M | 11,250 | $0.0000 | $0.00 |
| May 13, 2026 | SCHULMAN AMY W | Director | M | 11,250 | $70.2000 | $789.75K |
| Apr 6, 2026 | McLaughlin Melissa | Chief Human Resources Officer | S | 199 | $333.9400 | $66.45K |
| Apr 6, 2026 | McLaughlin Melissa | Chief Human Resources Officer | S | 293 | $331.8900 | $97.24K |
| Apr 6, 2026 | McLaughlin Melissa | Chief Human Resources Officer | S | 829 | $330.4600 | $273.95K |
| Apr 6, 2026 | McLaughlin Melissa | Chief Human Resources Officer | S | 909 | $329.7600 | $299.75K |
| Apr 6, 2026 | McLaughlin Melissa | Chief Human Resources Officer | S | 56 | $320.1400 | $17.93K |
| Apr 2, 2026 | McLaughlin Melissa | Chief Human Resources Officer | S | 8 | $325.4900 | $2.60K |
| Apr 2, 2026 | McLaughlin Melissa | Chief Human Resources Officer | S | 81 | $323.6400 | $26.21K |
| Apr 2, 2026 | McLaughlin Melissa | Chief Human Resources Officer | S | 245 | $322.8600 | $79.10K |
| Apr 2, 2026 | McLaughlin Melissa | Chief Human Resources Officer | S | 224 | $321.6400 | $72.05K |
| Apr 2, 2026 | McLaughlin Melissa | Chief Human Resources Officer | S | 147 | $320.6200 | $47.13K |
| Apr 2, 2026 | McLaughlin Melissa | Chief Human Resources Officer | S | 86 | $319.6900 | $27.49K |
| Apr 2, 2026 | McLaughlin Melissa | Chief Human Resources Officer | S | 209 | $318.4700 | $66.56K |
| Apr 2, 2026 | McLaughlin Melissa | Chief Human Resources Officer | S | 359 | $317.4400 | $113.96K |
| Apr 2, 2026 | McLaughlin Melissa | Chief Human Resources Officer | S | 265 | $316.6100 | $83.90K |
| Mar 5, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | 153 | $326.2400 | $49.91K |
| Mar 5, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | 148 | $324.6000 | $48.04K |
| Mar 5, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | 233 | $323.2500 | $75.32K |
| Mar 5, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | 124 | $321.8100 | $39.90K |
| Mar 5, 2026 | Garg Pushkal | EVP Chief R&D | S | 500 | $326.0800 | $163.04K |
| Mar 5, 2026 | Garg Pushkal | EVP Chief R&D | S | 510 | $324.5900 | $165.54K |
| Mar 5, 2026 | Garg Pushkal | EVP Chief R&D | S | 740 | $323.5500 | $239.43K |
| Mar 5, 2026 | Garg Pushkal | EVP Chief R&D | S | 654 | $322.3300 | $210.80K |