第一手 SEC EDGAR 13F-HR 機構持倉:依市值排序的前 25 大持有人，以及本季增持 / 減持最多的機構。季度 2026-03-31。
| 申報機構 | 持股數 | 市值 | Δ 持股 | 變動 |
|---|---|---|---|---|
EcoR1 Capital, LLCCIK 0001587114 | 22,970,388 | $575.18M | – | no_change |
Rubric Capital Management LPCIK 0001687509 | 7,000,000 | $175.28M | +1,250,000 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 4,553,888 | $114.03M | -41,660 | ↓ DEC |
BVF INC/ILCIK 0001056807 | 3,734,142 | $93.50M | -204,499 | ↓ DEC |
PERCEPTIVE ADVISORS LLCCIK 0001224962 | 3,510,078 | $87.89M | +248,228 | ↑ INC |
MORGAN STANLEYCIK 0000895421 | 2,480,568 | $62.11M | -112,512 | ↓ DEC |
BNP Paribas Asset Management Holding S.A.CIK 0001520354 | 1,908,039 | $47.78M | +85,991 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 1,705,580 | $42.71M | +1,705,580 | NEW |
CITADEL ADVISORS LLCCIK 0001423053 | 1,250,518 | $31.31M | +950,267 | ↑ INC |
DIMENSIONAL FUND ADVISORS LPCIK 0000354204 | 1,139,135 | $28.52M | -20,080 | ↓ DEC |
Nextech Invest, Ltd.CIK 0001595430 | 1,113,946 | $27.89M | – | no_change |
STATE STREET CORPCIK 0000093751 | 1,011,777 | $25.33M | -25,865 | ↓ DEC |
Capricorn Fund Managers LtdCIK 0001901361 | 1,007,210 | $25.22M | -15,630 | ↓ DEC |
DEUTSCHE BANK AG\CIK 0000948046 | 921,250 | $23.07M | -674,583 | ↓ DEC |
ARROWSTREET CAPITAL, LIMITED PARTNERSHIPCIK 0001164508 | 743,898 | $18.63M | +43,896 | ↑ INC |
Assenagon Asset Management S.A.CIK 0001546007 | 727,986 | $18.23M | +80,612 | ↑ INC |
FMR LLCCIK 0000315066 | 667,153 | $16.71M | +107,067 | ↑ INC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 659,940 | $16.52M | +11,970 | ↑ INC |
Nuveen, LLCCIK 0001871926 | 651,662 | $16.32M | +3,336 | ↑ INC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 599,486 | $15.01M | +179,279 | ↑ INC |
MPM BioImpact LLCCIK 0001687078 | 565,249 | $14.15M | +565,249 | NEW |
Prosight Management, LPCIK 0001617201 | 539,049 | $13.50M | +8,656 | ↑ INC |
Qube Research & Technologies LtdCIK 0001729829 | 511,937 | $12.82M | +37,647 | ↑ INC |
VANGUARD PORTFOLIO MANAGEMENT LLCCIK 0002100121 | 499,875 | $12.52M | +499,875 | NEW |
Redmile Group, LLCCIK 0001425738 | 491,654 | $12.31M | – | no_change |
| 申報機構 | Δ 持股 | 市值 |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +1,705,580 | $42.71M |
Rubric Capital Management LP↑ INC | +1,250,000 | $175.28M |
CITADEL ADVISORS LLC↑ INC | +950,267 | $31.31M |
MPM BioImpact LLCNEW | +565,249 | $14.15M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +499,875 | $12.52M |
ROYCE & ASSOCIATES LPNEW | +299,202 | $7.49M |
PERCEPTIVE ADVISORS LLC↑ INC | +248,228 | $87.89M |
GOLDMAN SACHS GROUP INC↑ INC | +179,279 | $15.01M |
JANE STREET GROUP, LLC↑ INC | +156,522 | $5.68M |
BANK OF AMERICA CORP /DE/↑ INC | +147,230 | $5.93M |
| 申報機構 | Δ 持股 | 市值 |
|---|---|---|
DEUTSCHE BANK AG\↓ DEC | -674,583 | $23.07M |
MILLENNIUM MANAGEMENT LLC↓ DEC | -331,621 | $1.25M |
BVF INC/IL↓ DEC | -204,499 | $93.50M |
SUSQUEHANNA INTERNATIONAL GROUP, LLP↓ DEC | -184,867 | $6.88M |
Squarepoint Ops LLC↓ DEC | -136,802 | $2.08M |
Invesco Ltd.↓ DEC | -131,950 | $3.15M |
MARSHALL WACE, LLP↓ DEC | -122,635 | $806.86K |
DIADEMA PARTNERS LP↓ DEC | -119,868 | $3.56M |
MORGAN STANLEY↓ DEC | -112,512 | $62.11M |
UBS Group AG↓ DEC | -107,075 | $4.30M |