第一手 SEC EDGAR 13F-HR 機構持倉:依市值排序的前 25 大持有人，以及本季增持 / 減持最多的機構。季度 2026-03-31。
| 申報機構 | 持股數 | 市值 | Δ 持股 | 變動 |
|---|---|---|---|---|
TCG Crossover Management, LLCCIK 0001839948 | 5,673,078 | $96.50M | +5,673,078 | NEW |
FCPM III SERVICES B.V.CIK 0002013410 | 4,117,354 | $73.45M | +500,000 | ↑ INC |
Venrock Adviser, LLCCIK 0001615982 | 3,041,719 | $54.26M | +1,097,953 | ↑ INC |
Frazier Life Sciences Management, L.P.CIK 0001892134 | 2,543,939 | $45.38M | – | no_change |
Caligan Partners LPCIK 0001727492 | 1,925,066 | $34.34M | +999,999 | ↑ INC |
GREAT POINT PARTNERS LLCCIK 0001281446 | 1,750,000 | $31.22M | +379,893 | ↑ INC |
Paradigm Biocapital Advisors LPCIK 0001855655 | 1,750,000 | $31.22M | – | no_change |
FMR LLCCIK 0000315066 | 1,539,670 | $27.47M | -986,500 | ↓ DEC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 1,433,280 | $25.57M | +1,433,280 | NEW |
MARSHALL WACE, LLPCIK 0001318757 | 1,153,276 | $20.57M | +1,153,276 | NEW |
STATE STREET CORPCIK 0000093751 | 1,118,458 | $19.95M | +1,027,405 | ↑ INC |
NEXTBio Capital Management LPCIK 0002038158 | 999,967 | $17.84M | – | no_change |
BlackRock, Inc.CIK 0002012383 | 794,759 | $14.18M | +329,123 | ↑ INC |
Rosalind Advisors, Inc.CIK 0001622627 | 700,000 | $12.49M | +700,000 | NEW |
BOOTHBAY FUND MANAGEMENT, LLCCIK 0001549230 | 555,702 | $9.91M | +555,702 | NEW |
UBS Group AGCIK 0001610520 | 488,368 | $8.71M | +196,250 | ↑ INC |
BRAIDWELL LPCIK 0001920938 | 466,774 | $8.33M | +466,774 | NEW |
SUSQUEHANNA INTERNATIONAL GROUP, LLPCIK 0001446194 | 408,808 | $7.29M | -961,211 | ↓ DEC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 342,573 | $6.11M | +156,765 | ↑ INC |
Clearline Capital LPCIK 0001600136 | 326,168 | $5.82M | +326,168 | NEW |
SPHERA FUNDS MANAGEMENT LTD.CIK 0001496201 | 321,917 | $5.74M | -88,500 | ↓ DEC |
Laurion Capital Management LPCIK 0001390202 | 318,670 | $5.69M | +1,427 | ↑ INC |
Propel Bio Management, LLCCIK 0001969764 | 314,543 | $5.59M | +314,543 | NEW |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 261,891 | $4.67M | +116,251 | ↑ INC |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 258,587 | $4.61M | +34,053 | ↑ INC |
| 申報機構 | Δ 持股 | 市值 |
|---|---|---|
TCG Crossover Management, LLCNEW | +5,673,078 | $96.50M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +1,433,280 | $25.57M |
MARSHALL WACE, LLPNEW | +1,153,276 | $20.57M |
Venrock Adviser, LLC↑ INC | +1,097,953 | $54.26M |
STATE STREET CORP↑ INC | +1,027,405 | $19.95M |
Caligan Partners LP↑ INC | +999,999 | $34.34M |
Rosalind Advisors, Inc.NEW | +700,000 | $12.49M |
BOOTHBAY FUND MANAGEMENT, LLCNEW | +555,702 | $9.91M |
FCPM III SERVICES B.V.↑ INC | +500,000 | $73.45M |
BRAIDWELL LPNEW | +466,774 | $8.33M |
| 申報機構 | Δ 持股 | 市值 |
|---|---|---|
FMR LLC↓ DEC | -986,500 | $27.47M |
SUSQUEHANNA INTERNATIONAL GROUP, LLP↓ DEC | -961,211 | $7.29M |
CITADEL ADVISORS LLC↓ DEC | -314,016 | $2.65M |
GROUP ONE TRADING LLC↓ DEC | -133,500 | $918.76K |
SPHERA FUNDS MANAGEMENT LTD.↓ DEC | -88,500 | $5.74M |
GROUP ONE TRADING LLC↓ DEC | -70,100 | $265.82K |
JANE STREET GROUP, LLC↓ DEC | -29,145 | $1.35M |
INDEPENDENT FINANCIAL GROUP, LLC↓ DEC | -3,025 | $249.31K |
Engineers Gate Manager LP↓ DEC | -1,324 | $479.54K |
BARCLAYS PLC↓ DEC | -1,263 | $2.43K |