第一手 SEC EDGAR 13F-HR 機構持倉:依市值排序的前 25 大持有人，以及本季增持 / 減持最多的機構。季度 2026-03-31。
| 申報機構 | 持股數 | 市值 | Δ 持股 | 變動 |
|---|---|---|---|---|
ORBIMED ADVISORS LLCCIK 0001055951 | 2,252,987 | $14.46M | – | no_change |
Atlas Venture Life Science Advisors, LLCCIK 0001917529 | 2,092,106 | $13.43M | – | no_change |
Opaleye Management Inc.CIK 0001595855 | 1,256,228 | $8.06M | +1,042,865 | ↑ INC |
Carlyle Group Inc.CIK 0001527166 | 1,102,741 | $7.08M | – | no_change |
ARCH Venture Management, LLCCIK 0001274403 | 320,482 | $2.06M | – | no_change |
ACORN CAPITAL ADVISORS, LLCCIK 0002054410 | 315,052 | $2.02M | -178,373 | ↓ DEC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 306,401 | $1.97M | +306,401 | NEW |
MACKENZIE FINANCIAL CORPCIK 0000919859 | 246,304 | $1.58M | +246,304 | NEW |
SanofiCIK 0001121404 | 244,083 | $1.57M | – | no_change |
RENAISSANCE TECHNOLOGIES LLCCIK 0001037389 | 206,915 | $1.33M | +107,315 | ↑ INC |
MONIMUS CAPITAL MANAGEMENT, LPCIK 0001848831 | 134,310 | $862.27K | +134,310 | NEW |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 118,152 | $758.74K | +12,039 | ↑ INC |
PFIZER INCCIK 0000078003 | 101,618 | $736.73K | -176,159 | ↓ DEC |
BlackRock, Inc.CIK 0002012383 | 86,147 | $553.06K | +26,215 | ↑ INC |
JANE STREET GROUP, LLCCIK 0001595888 | 65,599 | $421.14K | +40,225 | ↑ INC |
MARSHALL WACE, LLPCIK 0001318757 | 52,440 | $336.66K | +35,512 | ↑ INC |
VANGUARD FIDUCIARY TRUST COCIK 0000933478 | 49,995 | $320.97K | +49,995 | NEW |
TWO SIGMA INVESTMENTS, LPCIK 0001179392 | 42,346 | $271.86K | -4,479 | ↓ DEC |
STATE STREET CORPCIK 0000093751 | 41,514 | $266.52K | +20,277 | ↑ INC |
ADAR1 Capital Management, LLCCIK 0001940272 | 35,000 | $224.70K | +15,000 | ↑ INC |
Affinity Asset Advisors, LLCCIK 0001773195 | 27,777 | $178.33K | – | no_change |
NORTHERN TRUST CORPCIK 0000073124 | 25,033 | $160.71K | – | no_change |
Cetera Investment AdvisersCIK 0001666741 | 20,695 | $132.86K | +20,695 | NEW |
AMERICAN CENTURY COMPANIES INCCIK 0000748054 | 18,770 | $120.50K | +18,770 | NEW |
CITADEL ADVISORS LLCCIK 0001423053 | 15,481 | $99.39K | -30,247 | ↓ DEC |
| 申報機構 | Δ 持股 | 市值 |
|---|---|---|
Opaleye Management Inc.↑ INC | +1,042,865 | $8.06M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +306,401 | $1.97M |
MACKENZIE FINANCIAL CORPNEW | +246,304 | $1.58M |
MONIMUS CAPITAL MANAGEMENT, LPNEW | +134,310 | $862.27K |
ACADIAN ASSET MANAGEMENT LLC↑ INC | +124,213 | $1.11K |
RENAISSANCE TECHNOLOGIES LLC↑ INC | +107,315 | $1.33M |
VANGUARD FIDUCIARY TRUST CONEW | +49,995 | $320.97K |
JANE STREET GROUP, LLC↑ INC | +40,225 | $421.14K |
MARSHALL WACE, LLP↑ INC | +35,512 | $336.66K |
Cambridge Investment Research Advisors, Inc.NEW | +35,025 | $225.00 |
| 申報機構 | Δ 持股 | 市值 |
|---|---|---|
ACORN CAPITAL ADVISORS, LLC↓ DEC | -178,373 | $2.02M |
PFIZER INC↓ DEC | -176,159 | $736.73K |
CITADEL ADVISORS LLC↓ DEC | -30,247 | $99.39K |
UBS Group AG↓ DEC | -13,336 | $1.73K |
TWO SIGMA INVESTMENTS, LP↓ DEC | -4,479 | $271.86K |
EverSource Wealth Advisors, LLC↓ DEC | -3,530 | $48.48K |
WELLS FARGO & COMPANY/MN↓ DEC | -55 | $539.00 |
SBI Securities Co., Ltd.↓ DEC | -53 | $668.00 |
CWM, LLC↓ DEC | -15 | $250.00 |
OSAIC HOLDINGS, INC.↓ DEC | -8 | $796.00 |