第一手 SEC EDGAR 13F-HR 機構持倉:依市值排序的前 25 大持有人，以及本季增持 / 減持最多的機構。季度 2026-03-31。
| 申報機構 | 持股數 | 市值 | Δ 持股 | 變動 |
|---|---|---|---|---|
Nextech Invest, Ltd.CIK 0001595430 | 7,162,637 | $90.75M | – | no_change |
EcoR1 Capital, LLCCIK 0001587114 | 6,728,116 | $85.25M | – | no_change |
BlackRock, Inc.CIK 0002012383 | 5,984,552 | $75.82M | +109,499 | ↑ INC |
VIKING GLOBAL INVESTORS LPCIK 0001103804 | 5,824,533 | $73.80M | -748,158 | ↓ DEC |
SR ONE CAPITAL MANAGEMENT, LPCIK 0001910264 | 4,514,929 | $58.48M | – | no_change |
PFIZER INCCIK 0000078003 | 4,780,401 | $57.65M | -595,943 | ↓ DEC |
Venrock Adviser, LLCCIK 0001615982 | 4,319,765 | $54.73M | -1,356,465 | ↓ DEC |
NEA Management Company, LLCCIK 0001512848 | 4,118,621 | $52.18M | – | no_change |
STATE STREET CORPCIK 0000093751 | 3,702,196 | $46.91M | -556,201 | ↓ DEC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 3,687,007 | $46.71M | +3,687,007 | NEW |
Column Group LLCCIK 0001833486 | 3,540,777 | $44.86M | – | no_change |
Siren, L.L.C.CIK 0002005245 | 2,998,192 | $37.99M | +1,990,617 | ↑ INC |
ORBIMED ADVISORS LLCCIK 0001055951 | 2,693,929 | $34.13M | -947,827 | ↓ DEC |
AIHC Capital Management LtdCIK 0002103725 | 2,459,551 | $31.16M | +2,459,551 | NEW |
FMR LLCCIK 0000315066 | 2,434,080 | $30.84M | -44,842 | ↓ DEC |
CITADEL ADVISORS LLCCIK 0001423053 | 2,432,741 | $30.82M | -16,869 | ↓ DEC |
First Turn Management, LLCCIK 0001993440 | 2,017,284 | $25.56M | +6,977 | ↑ INC |
Vivo Capital, LLCCIK 0001674712 | 1,848,786 | $23.42M | -269,598 | ↓ DEC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 1,838,801 | $23.30M | +88,107 | ↑ INC |
MPM BioImpact LLCCIK 0001687078 | 1,803,945 | $22.86M | +5,228 | ↑ INC |
Paradigm Biocapital Advisors LPCIK 0001855655 | 1,701,217 | $21.55M | -700,000 | ↓ DEC |
MORGAN STANLEYCIK 0000895421 | 1,682,523 | $21.32M | +488,450 | ↑ INC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 1,475,712 | $18.70M | -463,573 | ↓ DEC |
DIMENSIONAL FUND ADVISORS LPCIK 0000354204 | 1,471,290 | $18.64M | +244,060 | ↑ INC |
FRANKLIN RESOURCES INCCIK 0000038777 | 1,452,835 | $18.41M | +240,288 | ↑ INC |
| 申報機構 | Δ 持股 | 市值 |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +3,687,007 | $46.71M |
AIHC Capital Management LtdNEW | +2,459,551 | $31.16M |
PRICE T ROWE ASSOCIATES INC /MD/↑ INC | +2,092,661 | $68.26K |
Siren, L.L.C.↑ INC | +1,990,617 | $37.99M |
BRAIDWELL LPNEW | +1,128,040 | $14.29M |
Woodline Partners LP↑ INC | +1,000,981 | $15.81M |
Sofinnova Investments, Inc.NEW | +679,578 | $8.61M |
Candriam S.C.A.NEW | +574,085 | $7.27M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +570,691 | $7.23M |
BANK OF AMERICA CORP /DE/↑ INC | +535,649 | $13.22M |
| 申報機構 | Δ 持股 | 市值 |
|---|---|---|
Boxer Capital Management, LLC↓ DEC | -1,556,071 | $2.24M |
Venrock Adviser, LLC↓ DEC | -1,356,465 | $54.73M |
ORBIMED ADVISORS LLC↓ DEC | -947,827 | $34.13M |
VIKING GLOBAL INVESTORS LP↓ DEC | -748,158 | $73.80M |
BARCLAYS PLC↓ DEC | -706,106 | $157.47K |
Paradigm Biocapital Advisors LP↓ DEC | -700,000 | $21.55M |
PFIZER INC↓ DEC | -595,943 | $57.65M |
STATE STREET CORP↓ DEC | -556,201 | $46.91M |
UBS Group AG↓ DEC | -540,169 | $2.47M |
SPHERA FUNDS MANAGEMENT LTD.↓ DEC | -466,750 | $6.81M |