第一手 SEC EDGAR 13F-HR 機構持倉:依市值排序的前 25 大持有人，以及本季增持 / 減持最多的機構。季度 2026-03-31。
| 申報機構 | 持股數 | 市值 | Δ 持股 | 變動 |
|---|---|---|---|---|
ORBIMED ADVISORS LLCCIK 0001055951 | 15,518,492 | $488.83M | – | no_change |
Paradigm Biocapital Advisors LPCIK 0001855655 | 7,365,038 | $232.00M | +823,828 | ↑ INC |
BAKER BROS. ADVISORS LPCIK 0001263508 | 6,575,940 | $207.14M | – | no_change |
BlackRock, Inc.CIK 0002012383 | 6,472,991 | $203.90M | -157,585 | ↓ DEC |
Novo Holdings A/SCIK 0001388325 | 5,350,000 | $168.53M | – | no_change |
DRIEHAUS CAPITAL MANAGEMENT LLCCIK 0000938206 | 4,477,942 | $141.06M | +286,749 | ↑ INC |
Siren, L.L.C.CIK 0002005245 | 4,430,263 | $139.55M | -99,727 | ↓ DEC |
PERCEPTIVE ADVISORS LLCCIK 0001224962 | 4,423,974 | $139.36M | -34,000 | ↓ DEC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 3,788,161 | $119.33M | +3,788,161 | NEW |
Cormorant Asset Management, LPCIK 0001583977 | 3,260,000 | $102.69M | -25,000 | ↓ DEC |
BRAIDWELL LPCIK 0001920938 | 2,347,583 | $73.95M | -2,863,248 | ↓ DEC |
MORGAN STANLEYCIK 0000895421 | 2,246,028 | $70.75M | -664,853 | ↓ DEC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 1,789,819 | $56.39M | +43,597 | ↑ INC |
STATE STREET CORPCIK 0000093751 | 1,716,823 | $54.08M | -520 | ↓ DEC |
MPM BioImpact LLCCIK 0001687078 | 1,660,696 | $52.31M | +5,440 | ↑ INC |
Bellevue Group AGCIK 0001674546 | 1,528,518 | $48.15M | – | no_change |
Soleus Capital Management, L.P.CIK 0001802630 | 1,449,915 | $45.67M | +539,915 | ↑ INC |
ALLIANCEBERNSTEIN L.P.CIK 0001109448 | 1,722,169 | $42.74M | +685,999 | ↑ INC |
BANK OF AMERICA CORP /DE/CIK 0000070858 | 1,327,360 | $41.81M | -147,437 | ↓ DEC |
UBS Group AGCIK 0001610520 | 1,311,125 | $41.30M | -805,948 | ↓ DEC |
DIMENSIONAL FUND ADVISORS LPCIK 0000354204 | 1,219,717 | $38.41M | +6,060 | ↑ INC |
AMERICAN CENTURY COMPANIES INCCIK 0000748054 | 1,147,176 | $36.14M | -39,291 | ↓ DEC |
FMR LLCCIK 0000315066 | 1,017,052 | $32.04M | +324,097 | ↑ INC |
First Light Asset Management, LLCCIK 0001600004 | 1,001,846 | $31.56M | -571,855 | ↓ DEC |
Aberdeen Group plcCIK 0001716774 | 826,059 | $26.02M | +4,119 | ↑ INC |
| 申報機構 | Δ 持股 | 市值 |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +3,788,161 | $119.33M |
Paradigm Biocapital Advisors LP↑ INC | +823,828 | $232.00M |
ALLIANCEBERNSTEIN L.P.↑ INC | +685,999 | $42.74M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +557,260 | $17.55M |
Soleus Capital Management, L.P.↑ INC | +539,915 | $45.67M |
Qube Research & Technologies Ltd↑ INC | +529,702 | $26.02M |
VANGUARD FIDUCIARY TRUST CONEW | +521,726 | $16.43M |
FMR LLC↑ INC | +324,097 | $32.04M |
DRIEHAUS CAPITAL MANAGEMENT LLC↑ INC | +286,749 | $141.06M |
CITADEL ADVISORS LLC↑ INC | +260,435 | $15.24M |
| 申報機構 | Δ 持股 | 市值 |
|---|---|---|
BRAIDWELL LP↓ DEC | -2,863,248 | $73.95M |
UBS Group AG↓ DEC | -805,948 | $41.30M |
MORGAN STANLEY↓ DEC | -664,853 | $70.75M |
First Light Asset Management, LLC↓ DEC | -571,855 | $31.56M |
EVENTIDE ASSET MANAGEMENT, LLC↓ DEC | -418,447 | $4.72M |
Pictet Asset Management Holding SA↓ DEC | -294,890 | $240.13K |
Ally Bridge Group (NY) LLC↓ DEC | -284,000 | $5.07M |
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND↓ DEC | -236,200 | $12.73M |
CITIGROUP INC↓ DEC | -204,777 | $583.29K |
BARCLAYS PLC↓ DEC | -195,494 | $5.58M |