| Jun 16, 2026 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | P | 61,523 | $24.9800 | $1.54M |
| Jun 15, 2026 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | P | 6,146 | $24.8900 | $152.97K |
| May 20, 2026 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | P | 996 | $24.9400 | $24.84K |
| May 19, 2026 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | P | 3,802 | $24.9700 | $94.94K |
| May 12, 2026 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | P | 6,387 | $24.9000 | $159.04K |
| May 11, 2026 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | P | 25,720 | $25.0000 | $643.00K |
| May 11, 2026 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | P | 14,149 | $24.4700 | $346.23K |
| May 8, 2026 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | P | 1,483 | $24.9800 | $37.05K |
| May 7, 2026 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | P | 1,985 | $24.9500 | $49.52K |
| May 7, 2026 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | P | 7,921 | $24.3400 | $192.80K |
| May 6, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | P | 53,407 | $24.8300 | $1.33M |
| May 6, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | P | 14,611 | $23.7700 | $347.30K |
| May 5, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | P | 10,268 | $25.0000 | $256.70K |
| May 5, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | P | 87,143 | $24.5900 | $2.14M |
| May 4, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | C | 221,188 | – | – |
| May 4, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | C | 1,253,384 | – | – |
| May 4, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | C | 399,212 | – | – |
| May 4, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | C | 931,502 | – | – |
| May 4, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | C | 609,840 | – | – |
| May 4, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | C | 1,422,960 | – | – |
| May 4, 2026 | Novo Holdings A/S | 10% Owner | C | 719,290 | $0.0000 | $0.00 |
| May 4, 2026 | Novo Holdings A/S | 10% Owner | C | 1,366,662 | $0.0000 | $0.00 |
| May 4, 2026 | Novo Holdings A/S | 10% Owner | C | 1,581,052 | $0.0000 | $0.00 |
| May 4, 2026 | Novo Holdings A/S | 10% Owner | C | 513,546 | $0.0000 | $0.00 |
| May 4, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | P | 133,750 | $18.0000 | $2.41M |
| May 4, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | P | 2,541,250 | $18.0000 | $45.74M |
| May 4, 2026 | Novo Holdings A/S | 10% Owner | C | 4,180,550 | – | – |
| May 4, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | C | 221,188 | – | – |
| May 4, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | C | 1,009,052 | – | – |
| May 4, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | C | 3,607,846 | – | – |
| May 4, 2026 | MARAGANORE JOHN | Director | C | 817 | $0.0000 | $0.00 |
| May 4, 2026 | MARAGANORE JOHN | Director | C | 817 | $0.0000 | $0.00 |
| May 4, 2026 | MARAGANORE JOHN | Director | C | 17,974 | – | – |
| May 4, 2026 | MARAGANORE JOHN | Director | C | 17,974 | – | – |
| Apr 30, 2026 | Behrndt-Eriksen Mads Nikolaj | See Remarks | A | 49,016 | $0.0000 | $0.00 |
| Apr 30, 2026 | Madigan Catherine | Chief Medical Officer | A | 49,016 | $0.0000 | $0.00 |
| Jan 29, 2026 | Behrndt-Eriksen Mads Nikolaj | See Remarks | A | 195,206 | $0.0000 | $0.00 |
| Jan 29, 2026 | Madigan Catherine | Chief Medical Officer | A | 145,134 | $0.0000 | $0.00 |
| Jan 29, 2026 | MARAGANORE JOHN | Director | A | 107,338 | $0.0000 | $0.00 |