First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
FMR LLCCIK 0000315066 | 9,082,000 | $177.55M | +1,377,745 | ↑ INC |
SR ONE CAPITAL MANAGEMENT, LPCIK 0001910264 | 5,037,854 | $98.49M | – | no_change |
NEA Management Company, LLCCIK 0001512848 | 4,023,219 | $78.65M | +500,000 | ↑ INC |
Enavate Sciences GP, LLCCIK 0001953107 | 3,919,159 | $76.62M | – | no_change |
DEERFIELD MANAGEMENT COMPANY, L.P.CIK 0001009258 | 65,000,000 | $67.25M | +65,000,000 | NEW |
FEDERATED HERMES, INC.CIK 0001056288 | 3,127,031 | $61.13M | +411,453 | ↑ INC |
Capital International InvestorsCIK 0001562230 | 2,434,000 | $47.58M | +2,434,000 | NEW |
Fairmount Funds Management LLCCIK 0001802528 | 2,359,025 | $46.12M | +150,000 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 2,037,548 | $39.83M | +270,030 | ↑ INC |
NVP Associates, LLCCIK 0001545692 | 1,838,482 | $35.94M | – | no_change |
ALLIANCEBERNSTEIN L.P.CIK 0001109448 | 897,321 | $32.58M | +878,971 | ↑ INC |
STATE STREET CORPCIK 0000093751 | 1,470,923 | $28.76M | +1,032,629 | ↑ INC |
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219 | 1,246,053 | $24.36M | +390,719 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 1,245,391 | $24.35M | +1,245,391 | NEW |
SILVERARC CAPITAL MANAGEMENT, LLCCIK 0001816307 | 1,135,935 | $22.21M | +1,135,935 | NEW |
EcoR1 Capital, LLCCIK 0001587114 | 789,500 | $15.43M | – | no_change |
BALYASNY ASSET MANAGEMENT L.P.CIK 0001218710 | 667,070 | $13.04M | +473,917 | ↑ INC |
ArrowMark Colorado Holdings LLCCIK 0001483859 | 658,909 | $12.88M | -92,252 | ↓ DEC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 655,785 | $12.82M | +67,392 | ↑ INC |
Pivotal bioVenture Partners Investment Advisor LLCCIK 0001844645 | 591,991 | $11.57M | – | no_change |
Woodline Partners LPCIK 0001784547 | 590,525 | $11.54M | +590,525 | NEW |
GREAT POINT PARTNERS LLCCIK 0001281446 | 524,066 | $10.25M | +524,066 | NEW |
Rock Springs Capital Management LPCIK 0001595725 | 502,077 | $9.82M | – | no_change |
MARSHALL WACE, LLPCIK 0001318757 | 501,928 | $9.81M | +494,828 | ↑ INC |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 476,818 | $9.32M | +427,658 | ↑ INC |
| Filer | Δ Shares | Value |
|---|---|---|
DEERFIELD MANAGEMENT COMPANY, L.P.NEW | +65,000,000 | $67.25M |
CITADEL ADVISORS LLCNEW | +8,000,000 | $8.29M |
Jefferies Financial Group Inc.NEW | +5,548,000 | $5.75M |
Monashee Investment Management LLCNEW | +3,152,000 | $3.21M |
Woodline Partners LPNEW | +2,500,000 | $2.58M |
Capital International InvestorsNEW | +2,434,000 | $47.58M |
FMR LLC↑ INC | +1,377,745 | $177.55M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +1,245,391 | $24.35M |
SILVERARC CAPITAL MANAGEMENT, LLCNEW | +1,135,935 | $22.21M |
STATE STREET CORP↑ INC | +1,032,629 | $28.76M |
| Filer | Δ Shares | Value |
|---|---|---|
ArrowMark Colorado Holdings LLC↓ DEC | -92,252 | $12.88M |
Invesco Ltd.↓ DEC | -74,489 | $2.22M |
VOLORIDGE INVESTMENT MANAGEMENT, LLC↓ DEC | -55,946 | $1.51M |
MORGAN STANLEY↓ DEC | -34,939 | $1.83M |
AQR CAPITAL MANAGEMENT LLC↓ DEC | -27,249 | $996.48K |
SCHRODER INVESTMENT MANAGEMENT GROUP↓ DEC | -16,939 | $614.13K |
WELLS FARGO & COMPANY/MN↓ DEC | -12,266 | $173.70K |
PRICE T ROWE ASSOCIATES INC /MD/↓ DEC | -11,982 | $6.99K |
BARCLAYS PLC↓ DEC | -4,767 | $578.88K |
Legal & General Group Plc↓ DEC | -2,595 | $203.95K |