First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
NEA Management Company, LLCCIK 0001512848 | 13,222,228 | $157.74M | – | no_change |
BlackRock, Inc.CIK 0002012383 | 10,240,186 | $122.17M | +114,003 | ↑ INC |
Frazier Life Sciences Management, L.P.CIK 0001892134 | 9,939,547 | $118.58M | -319,862 | ↓ DEC |
FMR LLCCIK 0000315066 | 8,038,061 | $95.89M | +1,538,052 | ↑ INC |
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219 | 5,189,088 | $61.91M | +1,785,098 | ↑ INC |
Vivo Capital, LLCCIK 0001674712 | 5,094,668 | $60.78M | – | no_change |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 4,978,567 | $59.39M | +4,978,567 | NEW |
MARSHALL WACE, LLPCIK 0001318757 | 3,966,019 | $47.31M | -614,529 | ↓ DEC |
Rubric Capital Management LPCIK 0001687509 | 3,712,373 | $44.29M | -54,376 | ↓ DEC |
MPM BioImpact LLCCIK 0001687078 | 3,298,430 | $39.35M | +11,343 | ↑ INC |
VIKING GLOBAL INVESTORS LPCIK 0001103804 | 3,198,644 | $38.16M | – | no_change |
ALLIANCEBERNSTEIN L.P.CIK 0001109448 | 2,845,472 | $35.63M | -237,514 | ↓ DEC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 2,778,231 | $33.15M | +365,346 | ↑ INC |
STATE STREET CORPCIK 0000093751 | 2,665,313 | $31.80M | +230,313 | ↑ INC |
EVENTIDE ASSET MANAGEMENT, LLCCIK 0001442891 | 2,622,306 | $31.28M | – | no_change |
ORBIMED ADVISORS LLCCIK 0001055951 | 2,454,400 | $29.28M | -736,300 | ↓ DEC |
Vestal Point Capital, LPCIK 0001974915 | 2,166,504 | $25.85M | +2,166,504 | NEW |
ACORN CAPITAL ADVISORS, LLCCIK 0002054410 | 2,144,844 | $25.59M | – | no_change |
Artia Global Partners LPCIK 0001937964 | 2,013,602 | $24.02M | – | no_change |
Affinity Asset Advisors, LLCCIK 0001773195 | 2,000,172 | $23.86M | -150,000 | ↓ DEC |
FRONTIER CAPITAL MANAGEMENT CO LLCCIK 0000351173 | 1,994,292 | $23.79M | +885,824 | ↑ INC |
EMERALD ADVISERS, LLCCIK 0001015083 | 1,839,566 | $21.95M | -52,710 | ↓ DEC |
Siren, L.L.C.CIK 0002005245 | 1,786,867 | $21.32M | -500,000 | ↓ DEC |
RAYMOND JAMES FINANCIAL INCCIK 0000720005 | 1,787,977 | $20.94M | -128,986 | ↓ DEC |
Pictet Asset Management Holding SACIK 0001993888 | 1,706,048 | $20.35M | +174,035 | ↑ INC |
| Filer | Δ Shares | Value |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +4,978,567 | $59.39M |
Vestal Point Capital, LPNEW | +2,166,504 | $25.85M |
WELLINGTON MANAGEMENT GROUP LLP↑ INC | +1,785,098 | $61.91M |
FMR LLC↑ INC | +1,538,052 | $95.89M |
CITADEL ADVISORS LLC↑ INC | +1,057,634 | $16.15M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +968,588 | $11.56M |
FRONTIER CAPITAL MANAGEMENT CO LLC↑ INC | +885,824 | $23.79M |
Candriam S.C.A.NEW | +773,620 | $9.23M |
Soleus Capital Management, L.P.↑ INC | +720,000 | $19.33M |
VANGUARD FIDUCIARY TRUST CONEW | +714,631 | $8.53M |
| Filer | Δ Shares | Value |
|---|---|---|
Octagon Capital Advisors LP↓ DEC | -1,330,000 | $17.72M |
Checkpoint Capital L.P.↓ DEC | -1,034,135 | $596.50K |
ORBIMED ADVISORS LLC↓ DEC | -736,300 | $29.28M |
MARSHALL WACE, LLP↓ DEC | -614,529 | $47.31M |
SUSQUEHANNA INTERNATIONAL GROUP, LLP↓ DEC | -589,560 | $6.75M |
PRUDENTIAL FINANCIAL INC↓ DEC | -534,493 | $175.68K |
BARCLAYS PLC↓ DEC | -529,068 | $639.27K |
Siren, L.L.C.↓ DEC | -500,000 | $21.32M |
Frazier Life Sciences Management, L.P.↓ DEC | -319,862 | $118.58M |
MORGAN STANLEY↓ DEC | -319,041 | $8.72M |