First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
FMR LLCCIK 0000315066 | 11,781,024 | $594.23M | +142,205 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 5,521,221 | $278.49M | -880 | ↓ DEC |
RTW INVESTMENTS, LPCIK 0001493215 | 4,171,996 | $210.44M | – | no_change |
Fairmount Funds Management LLCCIK 0001802528 | 4,018,101 | $202.67M | – | no_change |
PERCEPTIVE ADVISORS LLCCIK 0001224962 | 3,783,225 | $190.83M | +714,000 | ↑ INC |
Venrock Adviser, LLCCIK 0001615982 | 3,685,448 | $185.89M | – | no_change |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 3,057,401 | $154.22M | +3,057,401 | NEW |
DRIEHAUS CAPITAL MANAGEMENT LLCCIK 0000938206 | 2,790,785 | $140.77M | -91,635 | ↓ DEC |
STATE STREET CORPCIK 0000093751 | 2,607,031 | $131.50M | +344,192 | ↑ INC |
Paradigm Biocapital Advisors LPCIK 0001855655 | 1,957,266 | $98.72M | +490,000 | ↑ INC |
Commodore Capital LPCIK 0001831942 | 1,912,380 | $96.46M | -475,865 | ↓ DEC |
Remedium Capital Partners, LLCCIK 0002104501 | 1,907,327 | $96.21M | +451,096 | ↑ INC |
TCG Crossover Management, LLCCIK 0001839948 | 1,900,582 | $95.87M | – | no_change |
TANG CAPITAL MANAGEMENT LLCCIK 0001232621 | 1,892,200 | $95.44M | – | no_change |
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219 | 1,824,811 | $92.04M | +275,527 | ↑ INC |
Capital International InvestorsCIK 0001562230 | 1,746,129 | $88.07M | -1,746,412 | ↓ DEC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 1,720,912 | $86.82M | +61,772 | ↑ INC |
Affinity Asset Advisors, LLCCIK 0001773195 | 1,279,134 | $64.52M | -153,457 | ↓ DEC |
BANK OF AMERICA CORP /DE/CIK 0000070858 | 1,228,093 | $61.95M | +808,366 | ↑ INC |
BAKER BROS. ADVISORS LPCIK 0001263508 | 1,000,000 | $50.44M | – | no_change |
BRAIDWELL LPCIK 0001920938 | 932,823 | $47.05M | -701,792 | ↓ DEC |
FRANKLIN RESOURCES INCCIK 0000038777 | 882,833 | $44.53M | -226,441 | ↓ DEC |
JPMORGAN CHASE & COCIK 0000019617 | 979,299 | $44.48M | +916,348 | ↑ INC |
Caligan Partners LPCIK 0001727492 | 878,127 | $44.29M | +878,127 | NEW |
Siren, L.L.C.CIK 0002005245 | 818,598 | $41.29M | – | no_change |
| Filer | Δ Shares | Value |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +3,057,401 | $154.22M |
JPMORGAN CHASE & CO↑ INC | +916,348 | $44.48M |
Caligan Partners LPNEW | +878,127 | $44.29M |
BANK OF AMERICA CORP /DE/↑ INC | +808,366 | $61.95M |
PERCEPTIVE ADVISORS LLC↑ INC | +714,000 | $190.83M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +585,130 | $29.51M |
Paradigm Biocapital Advisors LP↑ INC | +490,000 | $98.72M |
Capital World Investors↑ INC | +466,392 | $33.62M |
VANGUARD FIDUCIARY TRUST CONEW | +464,651 | $23.44M |
Remedium Capital Partners, LLC↑ INC | +451,096 | $96.21M |
| Filer | Δ Shares | Value |
|---|---|---|
Capital International Investors↓ DEC | -1,746,412 | $88.07M |
BRAIDWELL LP↓ DEC | -701,792 | $47.05M |
Commodore Capital LP↓ DEC | -475,865 | $96.46M |
Pictet Asset Management Holding SA↓ DEC | -422,311 | $24.80M |
FRANKLIN RESOURCES INC↓ DEC | -226,441 | $44.53M |
Blackstone Inc.↓ DEC | -208,151 | $14.77M |
Caption Management, LLC↓ DEC | -162,100 | $11.99M |
Affinity Asset Advisors, LLC↓ DEC | -153,457 | $64.52M |
Patient Square Capital LP↓ DEC | -149,000 | $50.44K |
BARCLAYS PLC↓ DEC | -136,738 | $2.31M |