| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jul 6, 2026 | Shukla Abhinav A. | Chief Technical Officer | M | 12,153 | $0.0000 | $0.00 |
| Jul 6, 2026 | Shukla Abhinav A. | Chief Technical Officer | M | 12,153 | $3.5700 | $43.39K |
| Jul 2, 2026 | Shukla Abhinav A. | Chief Technical Officer | M | 410 | $0.0000 | $0.00 |
| Jul 2, 2026 | Shukla Abhinav A. | Chief Technical Officer | S | 410 | $7.0100 | $2.87K |
| Jul 2, 2026 | Shukla Abhinav A. | Chief Technical Officer | M | 410 | $3.5700 | $1.46K |
| Jul 1, 2026 | Shukla Abhinav A. | Chief Technical Officer | M | 100 | $0.0000 | $0.00 |
| Jul 1, 2026 | Shukla Abhinav A. | Chief Technical Officer | S | 100 | $7.0700 | $707.00 |
| Jul 1, 2026 | Shukla Abhinav A. | Chief Technical Officer | M | 100 | $3.5700 | $357.00 |
| Jun 30, 2026 | Pandite Arundathy N. | Chief Medical Officer | S | 30,000 | $7.0100 | $210.30K |
| Jun 30, 2026 | Shukla Abhinav A. | Chief Technical Officer | M | 23,365 | $0.0000 | $0.00 |
| Jun 30, 2026 | Shukla Abhinav A. | Chief Technical Officer | S | 23,365 | $7.0800 | $165.42K |
| Jun 30, 2026 | Shukla Abhinav A. | Chief Technical Officer | M | 23,365 | $3.5700 | $83.41K |
| Jun 11, 2026 | ORBIMED ADVISORS LLC | Director | P | 208,333 | – | – |
| Jun 11, 2026 | ORBIMED ADVISORS LLC | Director | P | 1,041,667 | – | – |
| Jun 11, 2026 | Ashiya Mona | Director | P | 208,333 | – | – |
| Jun 11, 2026 | Ashiya Mona | Director | P | 1,041,667 | – | – |
| Jun 9, 2026 | SIEGALL CLAY B | Director | P | 62,500 | $4.0000 | $250.00K |
| Jun 8, 2026 | Ashiya Mona | Director | C | 3,073,298 | – | – |
| Jun 8, 2026 | Ashiya Mona | Director | C | 15,366,490 | – | – |
| Jun 8, 2026 | Ashiya Mona | Director | C | 3,073,298 | – | – |
| Jun 8, 2026 | Ashiya Mona | Director | C | 15,366,490 | – | – |
| Jun 8, 2026 | ORBIMED ADVISORS LLC | Director | C | 3,073,298 | – | – |
| Jun 8, 2026 | ORBIMED ADVISORS LLC | Director | C | 15,366,490 | – | – |
| Jun 8, 2026 | ORBIMED ADVISORS LLC | Director | C | 3,073,298 | – | – |
| Jun 8, 2026 | ORBIMED ADVISORS LLC | Director | C | 15,366,490 | – | – |
| May 29, 2026 | SIEGALL CLAY B | Director | A | 81,000 | $0.0000 | $0.00 |
| May 29, 2026 | Boudreau Helen M | Director | A | 81,000 | $0.0000 | $0.00 |
| May 29, 2026 | Ashiya Mona | Director | A | 81,000 | $0.0000 | $0.00 |
| May 29, 2026 | Gibson Neil W | Director | A | 81,000 | $0.0000 | $0.00 |
| May 29, 2026 | Baker Daniel G. | Director | A | 81,000 | $0.0000 | $0.00 |
| May 29, 2026 | Golumbeski George | Director | A | 81,000 | $0.0000 | $0.00 |
| May 22, 2026 | SIEGALL CLAY B | Director | M | 128,054 | – | – |
| May 22, 2026 | SIEGALL CLAY B | Director | A | 128,054 | $1.0846 | $138.89K |
| May 21, 2026 | Shukla Abhinav A. | Chief Technical Officer | M | 5,122 | – | – |
| May 21, 2026 | Shukla Abhinav A. | Chief Technical Officer | A | 5,122 | $1.0846 | $5.55K |
| May 15, 2026 | Stout Stephen | See Remarks | M | 12,805 | – | – |
| May 15, 2026 | Stout Stephen | See Remarks | A | 12,805 | $1.0846 | $13.89K |
| May 12, 2026 | Schreiber Taylor | Chief Executive Officer | M | 25,610 | – | – |
| May 12, 2026 | Schreiber Taylor | Chief Executive Officer | A | 25,610 | $1.0846 | $27.78K |
| May 12, 2026 | Pandite Arundathy N. | Chief Medical Officer | S | 30,000 | $6.6100 | $198.30K |
| May 12, 2026 | Shukla Abhinav A. | Chief Technical Officer | M | 2,032 | $0.0000 | $0.00 |
| May 12, 2026 | Shukla Abhinav A. | Chief Technical Officer | S | 2,032 | $7.0100 | $14.24K |
| May 12, 2026 | Shukla Abhinav A. | Chief Technical Officer | M | 2,032 | $3.5700 | $7.25K |
| May 12, 2026 | Neill Andrew R | Chief Financial Officer | M | 64,027 | – | – |
| May 12, 2026 | Neill Andrew R | Chief Financial Officer | A | 64,027 | $1.0846 | $69.44K |
| May 10, 2026 | Stout Stephen | See Remarks | F | 968 | $6.8500 | $6.63K |
| Jan 25, 2026 | Neill Andrew R | Chief Financial Officer | F | 2,589 | $4.1500 | $10.74K |
| Jan 25, 2026 | DeYoung Casi | Chief Business Officer | F | 2,286 | $4.1500 | $9.49K |
| Jan 25, 2026 | Stout Stephen | See Remarks | F | 593 | $4.1500 | $2.46K |
| Jan 25, 2026 | Pandite Arundathy N. | Chief Medical Officer | F | 3,195 | $4.1500 | $13.26K |