First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
FMR LLCCIK 0000315066 | 17,243,152 | $847.67M | +1,862,477 | ↑ INC |
Siren, L.L.C.CIK 0002005245 | 10,825,013 | $532.16M | – | no_change |
Redmile Group, LLCCIK 0001425738 | 9,066,621 | $445.72M | +3,845,775 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 7,469,293 | $367.19M | +252,259 | ↑ INC |
Samsara BioCapital, LLCCIK 0001744967 | 6,897,652 | $339.09M | – | no_change |
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219 | 6,717,655 | $330.24M | +958,227 | ↑ INC |
Orbis Allan Gray LtdCIK 0001663865 | 4,179,983 | $205.49M | +751,054 | ↑ INC |
STATE STREET CORPCIK 0000093751 | 4,031,317 | $198.18M | -3,117 | ↓ DEC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 3,891,347 | $191.30M | +3,891,347 | NEW |
Bellevue Group AGCIK 0001674546 | 3,584,573 | $176.22M | -472,019 | ↓ DEC |
JENNISON ASSOCIATES LLCCIK 0000053417 | 3,340,492 | $164.22M | +545,304 | ↑ INC |
EVENTIDE ASSET MANAGEMENT, LLCCIK 0001442891 | 2,197,385 | $107.92M | -233,948 | ↓ DEC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 2,149,036 | $105.67M | +115,012 | ↑ INC |
Hood River Capital Management LLCCIK 0001578177 | 2,049,679 | $100.76M | +22,921 | ↑ INC |
DRIEHAUS CAPITAL MANAGEMENT LLCCIK 0000938206 | 1,920,233 | $94.40M | -32,644 | ↓ DEC |
Holocene Advisors, LPCIK 0001700574 | 1,890,927 | $92.96M | +503,807 | ↑ INC |
Woodline Partners LPCIK 0001784547 | 1,500,470 | $73.76M | +289,382 | ↑ INC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 1,411,683 | $69.40M | +87,470 | ↑ INC |
BANK OF AMERICA CORP /DE/CIK 0000070858 | 1,336,632 | $65.71M | +286,126 | ↑ INC |
Vestal Point Capital, LPCIK 0001974915 | 1,324,422 | $65.11M | +624,422 | ↑ INC |
Paradigm Biocapital Advisors LPCIK 0001855655 | 1,226,080 | $60.27M | -1,836,077 | ↓ DEC |
Capital World InvestorsCIK 0001422849 | 1,128,752 | $55.49M | – | no_change |
MARSHALL WACE, LLPCIK 0001318757 | 1,060,275 | $52.12M | +692,238 | ↑ INC |
STEMPOINT CAPITAL LPCIK 0001952142 | 1,135,496 | $51.49M | -28,397 | ↓ DEC |
CITADEL ADVISORS LLCCIK 0001423053 | 986,499 | $48.50M | +412,553 | ↑ INC |
| Filer | Δ Shares | Value |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +3,891,347 | $191.30M |
Redmile Group, LLC↑ INC | +3,845,775 | $445.72M |
FMR LLC↑ INC | +1,862,477 | $847.67M |
WELLINGTON MANAGEMENT GROUP LLP↑ INC | +958,227 | $330.24M |
Orbis Allan Gray Ltd↑ INC | +751,054 | $205.49M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +721,744 | $35.48M |
MARSHALL WACE, LLP↑ INC | +692,238 | $52.12M |
Vestal Point Capital, LP↑ INC | +624,422 | $65.11M |
VANGUARD FIDUCIARY TRUST CONEW | +589,048 | $28.96M |
JENNISON ASSOCIATES LLC↑ INC | +545,304 | $164.22M |
| Filer | Δ Shares | Value |
|---|---|---|
Paradigm Biocapital Advisors LP↓ DEC | -1,836,077 | $60.27M |
Point72 Asset Management, L.P.↓ DEC | -991,525 | $747.23K |
Bellevue Group AG↓ DEC | -472,019 | $176.22M |
Pictet Asset Management Holding SA↓ DEC | -320,883 | $43.02M |
EVENTIDE ASSET MANAGEMENT, LLC↓ DEC | -233,948 | $107.92M |
TWO SIGMA INVESTMENTS, LP↓ DEC | -226,851 | $8.78M |
UBS Group AG↓ DEC | -225,648 | $33.42M |
PRICE T ROWE ASSOCIATES INC /MD/↓ DEC | -195,819 | $305.12K |
BARCLAYS PLC↓ DEC | -183,862 | $9.49M |
MORGAN STANLEY↓ DEC | -153,704 | $10.77M |