| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jul 1, 2026 | Casale Donn | President | A | 898,456 | $0.0000 | $0.00 |
| Jun 24, 2026 | Shawver Laura | Director | A | 30,000 | $0.0000 | $0.00 |
| Jun 24, 2026 | SAUNDERS BRENT L | Director | A | 30,000 | $0.0000 | $0.00 |
| Jun 24, 2026 | SCHNEIDER PHILLIP M | Director | A | 30,000 | $0.0000 | $0.00 |
| Jun 24, 2026 | Thompson Peter A. | Director | A | 30,000 | $0.0000 | $0.00 |
| Jun 24, 2026 | Islam Saqib | Director | A | 30,000 | $0.0000 | $0.00 |
| Jun 24, 2026 | Kelly Michael | Director | A | 30,000 | $0.0000 | $0.00 |
| Jun 24, 2026 | Shah Pratik | Director | A | 30,000 | $0.0000 | $0.00 |
| Jun 24, 2026 | Dadoo Rajeev | Director | A | 30,000 | $0.0000 | $0.00 |
| Jun 24, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | A | 30,000 | $0.0000 | $0.00 |
| Jun 12, 2026 | Fitzpatrick Alexander A | Chief Legal Officer | S | 3,355 | $10.0000 | $33.55K |
| Jun 12, 2026 | Karas Eric | Chief Commercial Officer | M | 25,000 | $0.0000 | $0.00 |
| Jun 12, 2026 | Karas Eric | Chief Commercial Officer | S | 25,000 | $10.0000 | $250.00K |
| Jun 12, 2026 | Karas Eric | Chief Commercial Officer | M | 25,000 | $1.5000 | $37.50K |
| Jan 2, 2026 | Lowenthal Richard E | PRESIDENT AND CEO | A | 240,000 | $0.0000 | $0.00 |
| Jan 2, 2026 | Lowenthal Richard E | PRESIDENT AND CEO | A | 875,000 | $0.0000 | $0.00 |
| Jan 2, 2026 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | A | 875,000 | $0.0000 | $0.00 |
| Jan 2, 2026 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | A | 240,000 | $0.0000 | $0.00 |
| Jan 2, 2026 | Chakma Justin | Chief Business Officer | A | 240,000 | $0.0000 | $0.00 |
| Jan 2, 2026 | Dorsey Brian | Chief Operating Officer | A | 240,000 | $0.0000 | $0.00 |
| Jan 2, 2026 | Fitzpatrick Alexander A | Chief Legal Officer | A | 240,000 | $0.0000 | $0.00 |
| Jan 2, 2026 | Karas Eric | Chief Commercial Officer | A | 240,000 | $0.0000 | $0.00 |
| Jan 2, 2026 | Scott Kathleen D. | Chief Financial Officer | A | 240,000 | $0.0000 | $0.00 |
| Nov 13, 2025 | Dorsey Brian | Chief Operating Officer | M | 21,828 | $0.0000 | $0.00 |
| Nov 13, 2025 | Dorsey Brian | Chief Operating Officer | S | 21,828 | $8.7067 | $190.05K |
| Nov 13, 2025 | Dorsey Brian | Chief Operating Officer | M | 21,828 | $0.6400 | $13.97K |
| Nov 12, 2025 | Shah Pratik | Director | G | 100,000 | $0.0000 | $0.00 |
| Nov 12, 2025 | Shah Pratik | Director | G | 250,000 | $0.0000 | $0.00 |
| Nov 12, 2025 | Chakma Justin | Chief Business Officer | M | 30,000 | $0.0000 | $0.00 |
| Nov 12, 2025 | Chakma Justin | Chief Business Officer | S | 136,380 | $8.8634 | $1.21M |
| Nov 12, 2025 | Chakma Justin | Chief Business Officer | S | 30,000 | $8.9119 | $267.36K |
| Nov 12, 2025 | Chakma Justin | Chief Business Officer | M | 30,000 | $0.8400 | $25.20K |
| Aug 21, 2025 | Scott Kathleen D. | Chief Financial Officer | M | 12,500 | $0.0000 | $0.00 |
| Aug 21, 2025 | Scott Kathleen D. | Chief Financial Officer | S | 12,500 | $15.0000 | $187.50K |
| Aug 21, 2025 | Scott Kathleen D. | Chief Financial Officer | M | 12,500 | $1.5000 | $18.75K |
| Aug 21, 2025 | Lowenthal Richard E | PRESIDENT AND CEO | S | 50,000 | $14.4869 | $724.35K |
| Aug 20, 2025 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | S | 37,656 | $14.0914 | $530.63K |
| Aug 19, 2025 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | S | 12,344 | $14.0254 | $173.13K |
| Jul 1, 2025 | Karas Eric | Chief Commercial Officer | M | 15,000 | $0.0000 | $0.00 |
| Jul 1, 2025 | Karas Eric | Chief Commercial Officer | S | 15,000 | $16.9907 | $254.86K |
| Jul 1, 2025 | Karas Eric | Chief Commercial Officer | M | 15,000 | $1.5000 | $22.50K |
| Jun 27, 2025 | Flynn James E | 10% Owner | S | 370,074 | $18.4600 | $6.83M |
| Jun 27, 2025 | Flynn James E | 10% Owner | S | 370,075 | $18.4600 | $6.83M |
| Jun 25, 2025 | Shawver Laura | Director | A | 30,000 | $0.0000 | $0.00 |
| Jun 25, 2025 | SCHNEIDER PHILLIP M | Director | A | 30,000 | $0.0000 | $0.00 |
| Jun 25, 2025 | SAUNDERS BRENT L | Director | A | 30,000 | $0.0000 | $0.00 |
| Jun 25, 2025 | Thompson Peter A. | Director | A | 30,000 | $0.0000 | $0.00 |
| Jun 25, 2025 | Kelly Michael | Director | A | 30,000 | $0.0000 | $0.00 |
| Jun 25, 2025 | Islam Saqib | Director | A | 30,000 | $0.0000 | $0.00 |
| Jun 25, 2025 | Shah Pratik | Director | A | 30,000 | $0.0000 | $0.00 |