| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| May 29, 2026 | Spignesi Robert G. Jr. | PRESIDENT AND CEO | A | 12,787 | $0.0000 | $0.00 |
| May 29, 2026 | Spignesi Robert G. Jr. | PRESIDENT AND CEO | A | 12,787 | $0.0000 | $0.00 |
| May 29, 2026 | Spignesi Robert G. Jr. | PRESIDENT AND CEO | A | 12,787 | $1.9550 | $25.00K |
| May 29, 2026 | WIRTJES SEAN M | CHIEF FINANCIAL OFFICER | A | 12,787 | $0.0000 | $0.00 |
| May 29, 2026 | WIRTJES SEAN M | CHIEF FINANCIAL OFFICER | A | 12,787 | $0.0000 | $0.00 |
| May 29, 2026 | WIRTJES SEAN M | CHIEF FINANCIAL OFFICER | A | 12,787 | $1.9550 | $25.00K |
| May 29, 2026 | Malloy Kirk | Director | A | 12,787 | $0.0000 | $0.00 |
| May 29, 2026 | Malloy Kirk | Director | A | 12,787 | $0.0000 | $0.00 |
| May 29, 2026 | Malloy Kirk | Director | A | 12,787 | $1.9550 | $25.00K |
| May 29, 2026 | PEI MELINDA LITHERLAND | Director | A | 12,787 | $0.0000 | $0.00 |
| May 29, 2026 | PEI MELINDA LITHERLAND | Director | A | 12,787 | $0.0000 | $0.00 |
| May 29, 2026 | PEI MELINDA LITHERLAND | Director | A | 12,787 | $1.9550 | $25.00K |
| May 29, 2026 | LOWENSTEIN INESE | Director | A | 12,787 | $0.0000 | $0.00 |
| May 29, 2026 | LOWENSTEIN INESE | Director | A | 12,787 | $0.0000 | $0.00 |
| May 29, 2026 | LOWENSTEIN INESE | Director | A | 12,787 | $1.9550 | $25.00K |
| May 21, 2026 | Bika Dafni | Director | A | 38,700 | $0.0000 | $0.00 |
| May 21, 2026 | Bika Dafni | Director | A | 19,300 | $0.0000 | $0.00 |
| May 21, 2026 | Kollender Richard S | Director | A | 38,700 | $0.0000 | $0.00 |
| May 21, 2026 | Kollender Richard S | Director | A | 19,300 | $0.0000 | $0.00 |
| May 21, 2026 | PEI MELINDA LITHERLAND | Director | A | 38,700 | $0.0000 | $0.00 |
| May 21, 2026 | PEI MELINDA LITHERLAND | Director | A | 19,300 | $0.0000 | $0.00 |
| May 21, 2026 | LOWENSTEIN INESE | Director | A | 38,700 | $0.0000 | $0.00 |
| May 21, 2026 | LOWENSTEIN INESE | Director | A | 19,300 | $0.0000 | $0.00 |
| May 21, 2026 | Malloy Kirk | Director | A | 38,700 | $0.0000 | $0.00 |
| May 21, 2026 | Malloy Kirk | Director | A | 19,300 | $0.0000 | $0.00 |
| May 20, 2026 | Bain Capital Life Sciences Investors, LLC | 10% Owner | P | 1,463,000 | – | – |
| May 20, 2026 | Bain Capital Life Sciences Investors, LLC | 10% Owner | P | 1,463,000 | – | – |
| May 20, 2026 | Bain Capital Life Sciences Investors, LLC | 10% Owner | P | 1,463,000 | – | – |
| Mar 11, 2026 | WIRTJES SEAN M | CHIEF FINANCIAL OFFICER | S | 7,480 | $4.3181 | $32.30K |
| Mar 11, 2026 | Wilson John J. Addington | CHIEF OPERATING OFFICER | S | 9,603 | $4.3181 | $41.47K |
| Mar 10, 2026 | Spignesi Robert G. Jr. | PRESIDENT AND CEO | S | 17,922 | $4.1115 | $73.69K |
| Feb 27, 2026 | RICCIARDI NATALE S | Director | M | 842 | $0.7500 | $631.00 |
| Feb 27, 2026 | RICCIARDI NATALE S | Director | M | 842 | $0.7500 | $631.00 |
| Feb 20, 2026 | WIRTJES SEAN M | CHIEF FINANCIAL OFFICER | S | 17,254 | $3.9230 | $67.69K |
| Feb 20, 2026 | Wilson John J. Addington | CHIEF OPERATING OFFICER | S | 5,403 | $3.9230 | $21.20K |
| Feb 19, 2026 | Spignesi Robert G. Jr. | PRESIDENT AND CEO | S | 38,327 | $3.8853 | $148.91K |
| Feb 11, 2026 | Spignesi Robert G. Jr. | PRESIDENT AND CEO | A | 528,000 | $0.0000 | $0.00 |
| Feb 11, 2026 | Spignesi Robert G. Jr. | PRESIDENT AND CEO | A | 264,000 | $0.0000 | $0.00 |
| Feb 11, 2026 | WIRTJES SEAN M | CHIEF FINANCIAL OFFICER | A | 193,000 | $0.0000 | $0.00 |
| Feb 11, 2026 | WIRTJES SEAN M | CHIEF FINANCIAL OFFICER | A | 97,000 | $0.0000 | $0.00 |
| Feb 11, 2026 | Wilson John J. Addington | CHIEF OPERATING OFFICER | A | 147,000 | $0.0000 | $0.00 |
| Feb 11, 2026 | Wilson John J. Addington | CHIEF OPERATING OFFICER | A | 74,000 | $0.0000 | $0.00 |
| Feb 9, 2026 | Spignesi Robert G. Jr. | PRESIDENT AND CEO | S | 12,840 | $3.7827 | $48.57K |
| Feb 9, 2026 | WIRTJES SEAN M | CHIEF FINANCIAL OFFICER | S | 6,027 | $3.7827 | $22.80K |
| Feb 9, 2026 | Wilson John J. Addington | CHIEF OPERATING OFFICER | S | 4,610 | $3.7827 | $17.44K |
| Feb 4, 2026 | Longitude Capital Partners II, LLC | 10% Owner | S | 49,000 | $3.8794 | $190.09K |
| Feb 3, 2026 | Longitude Capital Partners II, LLC | 10% Owner | S | 27,500 | $4.2415 | $116.64K |
| Feb 2, 2026 | Longitude Capital Partners II, LLC | 10% Owner | S | 27,500 | $4.2460 | $116.77K |
| Jan 30, 2026 | Longitude Capital Partners II, LLC | 10% Owner | S | 46,000 | $4.5435 | $209.00K |
| Jan 23, 2026 | Longitude Capital Partners II, LLC | 10% Owner | X | 129,032 | $0.0000 | $0.00 |