| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 30, 2026 | Gault Cheryl | Chief Operating Officer | S | 1,000 | $43.1547 | $43.15K |
| Jun 30, 2026 | Gault Cheryl | Chief Operating Officer | S | 3,308 | $42.1722 | $139.50K |
| Jun 30, 2026 | Gault Cheryl | Chief Operating Officer | S | 3,792 | $41.3934 | $156.96K |
| Jun 30, 2026 | Gault Cheryl | Chief Operating Officer | S | 1,900 | $40.0914 | $76.17K |
| Jun 29, 2026 | Ceesay Abraham | Chief Executive Officer | S | 876 | $40.3375 | $35.34K |
| Jun 29, 2026 | Ceesay Abraham | Chief Executive Officer | S | 7,344 | $39.7688 | $292.06K |
| Jun 10, 2026 | Sanchez Ramiro | Director | A | 15,200 | $0.0000 | $0.00 |
| Jun 10, 2026 | Young Wendy B. | Director | A | 15,200 | $0.0000 | $0.00 |
| Jun 10, 2026 | Huber Reid M | Director | A | 15,200 | $0.0000 | $0.00 |
| Jun 10, 2026 | HEALY JAMES | Director | A | 15,200 | $0.0000 | $0.00 |
| Jun 10, 2026 | Silva Paul M | Director | A | 15,200 | $0.0000 | $0.00 |
| Jun 10, 2026 | PAUL STEVEN M | Director | A | 15,200 | $0.0000 | $0.00 |
| Jun 10, 2026 | PEREZ ROBERT J | Director | A | 15,200 | $0.0000 | $0.00 |
| Jun 10, 2026 | MARAGANORE JOHN | Director | A | 15,200 | $0.0000 | $0.00 |
| May 26, 2026 | Third Rock Ventures V, L.P. | 10% Owner | S | 18,572 | $40.0470 | $743.75K |
| May 11, 2026 | Third Rock Ventures V, L.P. | 10% Owner | S | 133,618 | $40.2440 | $5.38M |
| May 8, 2026 | Third Rock Ventures V, L.P. | 10% Owner | S | 5,018 | $40.3060 | $202.25K |
| May 7, 2026 | Third Rock Ventures V, L.P. | 10% Owner | S | 271,495 | $40.1210 | $10.89M |
| Apr 17, 2026 | Yeleswaram Krishnaswamy | Chief Development Officer | S | 20,225 | $39.9923 | $808.84K |
| Apr 17, 2026 | Third Rock Ventures V, L.P. | 10% Owner | S | 426,005 | $40.3170 | $17.18M |
| Apr 14, 2026 | Yeleswaram Krishnaswamy | Chief Development Officer | S | 10,200 | $35.0781 | $357.80K |
| Apr 13, 2026 | Yeleswaram Krishnaswamy | Chief Development Officer | S | 9,165 | $34.9740 | $320.54K |
| Apr 10, 2026 | Yeleswaram Krishnaswamy | Chief Development Officer | S | 500 | $34.9800 | $17.49K |
| Apr 8, 2026 | Yeleswaram Krishnaswamy | Chief Development Officer | S | 360 | $34.9000 | $12.56K |
| Mar 30, 2026 | Gault Cheryl | Chief Operating Officer | S | 2,839 | $28.5530 | $81.06K |
| Mar 30, 2026 | Gault Cheryl | Chief Operating Officer | S | 7,161 | $28.0401 | $200.79K |
| Mar 25, 2026 | Yeleswaram Krishnaswamy | Chief Development Officer | S | 10,115 | $29.9906 | $303.35K |
| Mar 5, 2026 | Gault Cheryl | Chief Operating Officer | S | 2,014 | $28.9300 | $58.27K |
| Feb 19, 2026 | Bredt David | Chief Scientific Officer | M | 6,000 | $0.0000 | $0.00 |
| Feb 19, 2026 | Bredt David | Chief Scientific Officer | M | 6,000 | $1.8000 | $10.80K |
| Feb 18, 2026 | Ceesay Abraham | Chief Executive Officer | S | 2,100 | $29.7965 | $62.57K |
| Feb 18, 2026 | Ceesay Abraham | Chief Executive Officer | S | 2,983 | $29.0443 | $86.64K |
| Feb 18, 2026 | Ceesay Abraham | Chief Executive Officer | S | 2,281 | $29.7983 | $67.97K |
| Feb 18, 2026 | Ceesay Abraham | Chief Executive Officer | S | 3,552 | $29.0516 | $103.19K |
| Feb 17, 2026 | Bredt David | Chief Scientific Officer | S | 2,200 | $29.5944 | $65.11K |
| Feb 17, 2026 | Bredt David | Chief Scientific Officer | S | 5,400 | $28.9497 | $156.33K |
| Feb 17, 2026 | Bredt David | Chief Scientific Officer | S | 900 | $28.0211 | $25.22K |
| Feb 2, 2026 | Gault Cheryl | Chief Operating Officer | A | 132,000 | $0.0000 | $0.00 |
| Feb 2, 2026 | Bredt David | Chief Scientific Officer | A | 103,000 | $0.0000 | $0.00 |
| Feb 2, 2026 | Yeleswaram Krishnaswamy | Chief Development Officer | A | 120,000 | $0.0000 | $0.00 |
| Feb 2, 2026 | Ignelzi Troy A. | Chief Financial Officer | A | 148,000 | $0.0000 | $0.00 |
| Feb 2, 2026 | Ceesay Abraham | Chief Executive Officer | A | 428,000 | $0.0000 | $0.00 |
| Feb 2, 2026 | Sevigny Jeffrey | Chief Medical Officer | A | 130,000 | $0.0000 | $0.00 |
| Jan 20, 2026 | Ceesay Abraham | Chief Executive Officer | S | 5,083 | $26.1140 | $132.74K |
| Jan 20, 2026 | Ceesay Abraham | Chief Executive Officer | S | 5,833 | $26.1158 | $152.33K |
| Jan 15, 2026 | Bredt David | Chief Scientific Officer | S | 200 | $27.4000 | $5.48K |
| Jan 15, 2026 | Bredt David | Chief Scientific Officer | S | 8,300 | $26.8255 | $222.65K |
| Dec 31, 2025 | Yeleswaram Krishnaswamy | Chief Development Officer | S | 2,840 | $30.0500 | $85.34K |
| Dec 31, 2025 | Yeleswaram Krishnaswamy | Chief Development Officer | A | 9,000 | – | – |
| Dec 31, 2025 | Bredt David | Chief Scientific Officer | S | 6,567 | $30.0499 | $197.34K |