First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
SUVRETTA CAPITAL MANAGEMENT, LLCCIK 0001569064 | 1,153,496 | $143.78M | +261,096 | ↑ INC |
First Light Asset Management, LLCCIK 0001600004 | 980,758 | $122.25M | +271,617 | ↑ INC |
BVF INC/ILCIK 0001056807 | 960,989 | $119.79M | +81,980 | ↑ INC |
Frazier Life Sciences Management, L.P.CIK 0001892134 | 882,400 | $109.99M | +160,000 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 686,853 | $85.62M | +127,788 | ↑ INC |
JENNISON ASSOCIATES LLCCIK 0000053417 | 640,611 | $79.85M | +253,128 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 477,294 | $59.49M | +477,294 | NEW |
STATE STREET CORPCIK 0000093751 | 458,999 | $57.21M | +38,537 | ↑ INC |
FEDERATED HERMES, INC.CIK 0001056288 | 433,015 | $53.98M | +64,977 | ↑ INC |
FRONTIER CAPITAL MANAGEMENT CO LLCCIK 0000351173 | 374,035 | $46.62M | +374,035 | NEW |
Woodline Partners LPCIK 0001784547 | 317,517 | $39.58M | +16,981 | ↑ INC |
Siren, L.L.C.CIK 0002005245 | 257,485 | $32.10M | +182,485 | ↑ INC |
Caption Management, LLCCIK 0001706766 | 237,100 | $29.55M | +45,800 | ↑ INC |
EVENTIDE ASSET MANAGEMENT, LLCCIK 0001442891 | 233,248 | $29.05M | +131,500 | ↑ INC |
ALLIANCEBERNSTEIN L.P.CIK 0001109448 | 262,835 | $27.51M | -6,192 | ↓ DEC |
FMR LLCCIK 0000315066 | 215,808 | $26.90M | -15,952 | ↓ DEC |
MPM BioImpact LLCCIK 0001687078 | 206,404 | $25.73M | +659 | ↑ INC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 205,609 | $25.64M | +26,617 | ↑ INC |
PRIMECAP MANAGEMENT CO/CA/CIK 0000763212 | 195,030 | $24.31M | +195,030 | NEW |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 194,179 | $24.20M | +95,244 | ↑ INC |
Artisan Partners Limited PartnershipCIK 0001466153 | 193,796 | $24.16M | -17,757 | ↓ DEC |
SUSQUEHANNA INTERNATIONAL GROUP, LLPCIK 0001446194 | 192,908 | $24.05M | +154,708 | ↑ INC |
ORBIMED ADVISORS LLCCIK 0001055951 | 184,600 | $23.01M | +184,600 | NEW |
Alyeska Investment Group, L.P.CIK 0001453072 | 179,922 | $22.43M | +179,922 | NEW |
EMERALD ADVISERS, LLCCIK 0001015083 | 161,500 | $20.13M | +161,500 | NEW |
| Filer | Δ Shares | Value |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +477,294 | $59.49M |
PRICE T ROWE ASSOCIATES INC /MD/↑ INC | +398,474 | $50.18K |
FRONTIER CAPITAL MANAGEMENT CO LLCNEW | +374,035 | $46.62M |
First Light Asset Management, LLC↑ INC | +271,617 | $122.25M |
SUVRETTA CAPITAL MANAGEMENT, LLC↑ INC | +261,096 | $143.78M |
JENNISON ASSOCIATES LLC↑ INC | +253,128 | $79.85M |
PRIMECAP MANAGEMENT CO/CA/NEW | +195,030 | $24.31M |
ORBIMED ADVISORS LLCNEW | +184,600 | $23.01M |
Siren, L.L.C.↑ INC | +182,485 | $32.10M |
Alyeska Investment Group, L.P.NEW | +179,922 | $22.43M |
| Filer | Δ Shares | Value |
|---|---|---|
FRED ALGER MANAGEMENT, LLC↓ DEC | -128,790 | $2.65M |
MORGAN STANLEY↓ DEC | -92,675 | $15.95M |
Samsara BioCapital, LLC↓ DEC | -66,385 | $4.79M |
BARCLAYS PLC↓ DEC | -23,145 | $248.18K |
Artisan Partners Limited Partnership↓ DEC | -17,757 | $24.16M |
FMR LLC↓ DEC | -15,952 | $26.90M |
BALYASNY ASSET MANAGEMENT L.P.↓ DEC | -12,154 | $12.06M |
Blue Owl Capital Holdings LP↓ DEC | -9,000 | $3.90M |
Mariner, LLC↓ DEC | -7,195 | $551.04K |
BOOTHBAY FUND MANAGEMENT, LLC↓ DEC | -6,570 | $2.36M |